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Article

Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway

  • Authors:
    • Jing Wang
    • Li Cui
    • Liang Feng
    • Zhenhai Zhang
    • Jie Song
    • Dan Liu
    • Xiaobin Jia
  • View Affiliations / Copyright

    Affiliations: Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China
  • Pages: 1269-1276
    |
    Published online on: July 20, 2016
       https://doi.org/10.3892/or.2016.4954
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Abstract

Isoalantolactone is a bioactive sesquiterpene lactone isolated from the flowering plant Inula helenium L. This study was conducted to assess the anti-migratory and anti-invasive activities of isoalantolactone in MDA-MB-231 cells, and to explore the underlying mechanisms. Wound-healing and Transwell chambers assays demonstrated that isoalantolactone inhibited the adhesion, migration and invasion of MDA-MB-231 cells. The activity and expression of MMP-2 and MMP-9 were downregulated by isoalantolactone in a dose-dependent manner. Additionally, isoalantolactone markedly decreased the p-p38 MAPK level, whereas no significant change in p-ERK1/2 and p-JNK1/2 was noted. The downregulation of MMP-2 and MMP-9 protein expression and suppression of in vitro invasion might be associated with the blockade of p38 MAPK activation. Furthermore, isoalantolactone blocked the translocation of NF-κB p65 from the cytoplasm into the nucleus. These results revealed that isoalantolactone inhibited the adhesion, migration and invasion of MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway, and isoalantolactone might be an alternative treatment for breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Cui L, Feng L, Zhang Z, Song J, Liu D and Jia X: Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway. Oncol Rep 36: 1269-1276, 2016.
APA
Wang, J., Cui, L., Feng, L., Zhang, Z., Song, J., Liu, D., & Jia, X. (2016). Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway. Oncology Reports, 36, 1269-1276. https://doi.org/10.3892/or.2016.4954
MLA
Wang, J., Cui, L., Feng, L., Zhang, Z., Song, J., Liu, D., Jia, X."Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway". Oncology Reports 36.3 (2016): 1269-1276.
Chicago
Wang, J., Cui, L., Feng, L., Zhang, Z., Song, J., Liu, D., Jia, X."Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway". Oncology Reports 36, no. 3 (2016): 1269-1276. https://doi.org/10.3892/or.2016.4954
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Cui L, Feng L, Zhang Z, Song J, Liu D and Jia X: Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway. Oncol Rep 36: 1269-1276, 2016.
APA
Wang, J., Cui, L., Feng, L., Zhang, Z., Song, J., Liu, D., & Jia, X. (2016). Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway. Oncology Reports, 36, 1269-1276. https://doi.org/10.3892/or.2016.4954
MLA
Wang, J., Cui, L., Feng, L., Zhang, Z., Song, J., Liu, D., Jia, X."Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway". Oncology Reports 36.3 (2016): 1269-1276.
Chicago
Wang, J., Cui, L., Feng, L., Zhang, Z., Song, J., Liu, D., Jia, X."Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway". Oncology Reports 36, no. 3 (2016): 1269-1276. https://doi.org/10.3892/or.2016.4954
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