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Article

Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway

  • Authors:
    • Xingwei Zhao
    • Qiang Zhang
    • Liang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong, P.R. China
  • Pages: 1499-1505
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    Published online on: July 21, 2016
       https://doi.org/10.3892/or.2016.4957
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Abstract

Research on triptolide, a diterpenoid epoxide found in the Thunder God Vine Tripterygium wilfordii, has increased our knowledge of the pharmacology, pharmacokinetics, toxicology and clinical application of this agent. In the present study, we aimed to identify the effects of triptolide on the apoptosis of osteosarcoma cells and to evaluate the anti-proliferative action of this agent. MG-63 cells were treated either with various doses of triptolide (50, 100 or 200 nM) or DMSO for 6, 12 and 24 h. Treatment with triptolide effectively suppressed the cell viability and induced the apoptosis of osteosarcoma MG-63 cells as detected by MTT assay and flow cytometry, respectively. In addition, by using caspase-3, caspase-8 and caspase-9 activity assays and western blot analysis, the anticancer effects of triptolide against osteosarcoma growth were found to involve activation of the DR-5/p53/Bax/caspase-9/ caspase-3 signaling pathway and the DR-5/FADD/caspase-8/lysosomal/cathepsin B/caspase-3 signaling pathway in the MG-63 cells. An important factor in the anticancer effects of triptolide against osteosarcoma was TRAIL-DR-5. The data suggest that triptolide may be a potential novel chemotherapeutic agent for osteosarcoma and acts through the TRAIL-DR-5 signaling pathway.
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View References

1 

Ferrari S, Meazza C, Palmerini E, Tamburini A, Fagioli F, Cozza R, Ferraresi V, Bisogno G, Mascarin M, Cefalo G, et al: Nonmetastatic osteosarcoma of the extremity. Neoadjuvant chemotherapy with methotrexate, cisplatin, doxorubicin and ifosfamide An Italian Sarcoma Group study (ISG/OS-Oss). Tumori. 100:612–619. 2014.

2 

Zalupski MM, Rankin C, Ryan JR, Lucas DR, Muler J, Lanier KS, Budd GT, Biermann JS, Meyers FJ and Antman K: Adjuvant therapy of osteosarcoma - A phase II trial: Southwest Oncology Group study 9139. Cancer. 100:818–825. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Nagarajan R, Clohisy DR, Neglia JP, Yasui Y, Mitby PA, Sklar C, Finklestein JZ, Greenberg M, Reaman GH, Zeltzer L, et al: Function and quality-of-life of survivors of pelvic and lower extremity osteosarcoma and Ewing's sarcoma: The Childhood Cancer Survivor Study. Br J Cancer. 91:1858–1865. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Berg J, Gebhardt MC and Rand WM: Effect of timing of postoperative chemotherapy on survival of dogs with osteosarcoma. Cancer. 79:1343–1350. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Grignani G, Palmerini E, Ferraresi V, D'Ambrosio L, Bertulli R, Asaftei SD, Tamburini A, Pignochino Y, Sangiolo D, Marchesi E, et al Italian Sarcoma Group: Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: A non-randomised phase 2 clinical trial. Lancet Oncol. 16:98–107. 2015. View Article : Google Scholar

6 

Petrilli AS, de Camargo B, Filho VO, Bruniera P, Brunetto AL, Jesus-Garcia R, Camargo OP, Pena W, Péricles P, Davi A, et al Brazilian Osteosarcoma Treatment Group Studies III and IV: Results of the Brazilian Osteosarcoma Treatment Group Studies III and IV: Prognostic factors and impact on survival. J Clin Oncol. 24:1161–1168. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Yan M, Ni J, Song D, Ding M and Huang J: Activation of unfolded protein response protects osteosarcoma cells from cisplatin-induced apoptosis through NF-κB pathway. Int J Clin Exp Pathol. 8:10204–10215. 2015.

8 

Yang TM, Qi SN, Zhao N, Yang YJ, Yuan HQ, Zhang B and Jin S: Induction of apoptosis through caspase-independent or caspase-9-dependent pathway in mouse and human osteosarcoma cells by a new nitroxyl spin-labeled derivative of podophyllotoxin. Apoptosis. 18:727–738. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Hanikoglu F, Cort A, Ozben H, Hanikoglu A and Ozben T: Epoxomicin sensitizes resistant osteosarcoma cells to TRAIL induced apoptosis. Anticancer Agents Med Chem. 15:527–533. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Hotta T, Suzuki H, Nagai S, Yamamoto K, Imakiire A, Takada E, Itoh M and Mizuguchi J: Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. J Orthop Res. 21:949–957. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Locklin RM, Federici E, Espina B, Hulley PA, Russell RG and Edwards CM: Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis. Mol Cancer Ther. 6:3219–3228. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Sonnemann J, Trommer N, Becker S, Wittig S, Grauel D, Palani CD and Beck JF: Histone deacetylase inhibitor-mediated sensitization to TRAIL-induced apoptosis in childhood malignancies is not associated with upregulation of TRAIL receptor expression, but with potentiated caspase-8 activation. Cancer Biol Ther. 13:417–424. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Sage EK, Kolluri KK, McNulty K, Lourenco SS, Kalber TL, Ordidge KL, Davies D, Gary Lee YC, Giangreco A and Janes SM: Systemic but not topical TRAIL-expressing mesenchymal stem cells reduce tumour growth in malignant mesothelioma. Thorax. 69:638–647. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Lamothe B and Aggarwal BB: Ectopic expression of Bcl-2 and Bcl-xL inhibits apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) through suppression of caspases-8, 7, and 3 and BID cleavage in human acute myelogenous leukemia cell line HL-60. J Interferon Cytokine Res. 22:269–279. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Saggioro FP, Neder L, Stávale JN, Paixão-Becker AN, Malheiros SM, Soares FA, Pittella JE, Matias CC, Colli BO, Carlotti CG Jr, et al: Fas, FasL, and cleaved caspases 8 and 3 in glioblastomas: A tissue microarray-based study. Pathol Res Pract. 210:267–273. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Owa C, Messina ME Jr and Halaby R: Triptolide induces lysosomal-mediated programmed cell death in MCF-7 breast cancer cells. Int J Womens Health. 5:557–569. 2013.PubMed/NCBI

17 

Pan J: RNA polymerase - an important molecular target of triptolide in cancer cells. Cancer Lett. 292:149–152. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Liu Q: Triptolide and its expanding multiple pharmacological functions. Int Immunopharmacol. 11:377–383. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Alvarez FJ, Kisseberth W, Hosoya K, Lara-Garcia A, Kosarek C, Murahari S, Au JL, Wientjes MG, Couto J and Couto G: Postoperative adjuvant combination therapy with doxorubicin and noncytotoxic suramin in dogs with appendicular osteosarcoma. J Am Anim Hosp Assoc. 50:12–18. 2014. View Article : Google Scholar

20 

Arndt CA, Koshkina NV, Inwards CY, Hawkins DS, Krailo MD, Villaluna D, Anderson PM, Goorin AM, Blakely ML, Bernstein M, et al: Inhaled granulocyte-macrophage colony stimulating factor for first pulmonary recurrence of osteosarcoma: Effects on disease-free survival and immunomodulation. A report from the Children's Oncology Group. Clin Cancer Res. 16:4024–4030. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Rakha EA, Tan PH, Shaaban A, Tse GM, Esteller FC, van Deurzen CH, Purnell D, Stotter A, Chan T, Yamaguchi R, et al: Do primary mammary osteosarcoma and chondrosarcoma exist? A review of a large multi-institutional series of malignant matrix-producing breast tumours. Breast. 22:13–18. 2013. View Article : Google Scholar

22 

Reno TA, Kim JY and Raz DJ: Triptolide inhibits lung cancer cell migration, invasion, and metastasis. Ann Thorac Surg. 100:1817–1824; discussion 1824–1825. 2015. View Article : Google Scholar : PubMed/NCBI

23 

van Raam BJ and Salvesen GS: Proliferative versus apoptotic functions of caspase-8 Hetero or homo: The caspase-8 dimer controls cell fate. Biochim Biophys Acta. 1824:113–122. 2012. View Article : Google Scholar

24 

Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsunomiya A, Watanabe T, et al: A20 targets caspase-8 and FADD to protect HTLV-I-infected cells. Leukemia. Oct 6–2015, (Epub ahead of print) http://dx.doi.org/10.1038/leu.2015.267.

25 

Kang S, Fernandes-Alnemri T, Rogers C, Mayes L, Wang Y, Dillon C, Roback L, Kaiser W, Oberst A, Sagara J, et al: Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun. 6:75152015. View Article : Google Scholar : PubMed/NCBI

26 

Deng XU, Xia KE, Chen PO, Ali Sheikh MS, Yang DF, Li SM and Yang TL: Reversion of left ventricle remodeling in spontaneously hypertensive rats by valsartan is associated with the inhibition of caspase-3, -8 and -9 activities. Biomed Rep. 3:533–536. 2015.PubMed/NCBI

27 

Lin ML, Lu YC, Su HL, Lin HT, Lee CC, Kang SE, Lai TC, Chung JG and Chen SS: Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells. J Cell Biochem. 112:1176–1191. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Kaseta MK, Gomatos IP, Khaldi L, Tzagarakis GP, Alevizos L, Themistocleous GS, Leandros E and Soucacos PN: Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma. Hybridoma (Larchmt). 26:355–362. 2007. View Article : Google Scholar

29 

Kataoka T: The caspase-8 modulator c-FLIP. Crit Rev Immunol. 25:31–58. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Zhao F, Huang W, Ousman T, Zhang B, Han Y, Clotaire DZ, Wang C, Chang H, Luo H, Ren X, et al: Triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradation. PLoS One. 8:e807842013. View Article : Google Scholar : PubMed/NCBI

31 

Lee JY, Jung KH, Morgan MJ, Kang YR, Lee HS, Koo GB, Hong SS, Kwon SW and Kim YS: Sensitization of TRAIL-induced cell death by 20(S)-ginsenoside Rg3 via CHOP-mediated DR5 upregulation in human hepatocellular carcinoma cells. Mol Cancer Ther. 12:274–285. 2013. View Article : Google Scholar

32 

Kim EY, Yu JS, Yang M and Kim AK: Sub-toxic dose of apigenin sensitizes HepG2 cells to TRAIL through ERK-dependent up-regulation of TRAIL receptor DR5. Mol Cells. 35:32–40. 2013. View Article : Google Scholar

33 

Carter BZ, Mak DH, Schober WD, Dietrich MF, Pinilla C, Vassilev LT, Reed JC and Andreeff M: Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5. Blood. 111:3742–3750. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Gordy C, Liang J, Pua H and He YW: c-FLIP protects eosinophils from TNF-α-mediated cell death in vivo. PLoS One. 9:e1077242014. View Article : Google Scholar

35 

Haag C, Stadel D, Zhou S, Bachem MG, Möller P, Debatin KM and Fulda S: Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells. Gut. 60:225–237. 2011. View Article : Google Scholar

36 

Schleich K, Buchbinder JH, Pietkiewicz S, Kähne T, Warnken U, Öztürk S, Schnölzer M, Naumann M, Krammer PH and Lavrik IN: Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain. Cell Death Differ. Oct 23–2015, (Epub ahead of print) http://dx.doi.org/10.1038/cdd.2015.137.

37 

Chen Z, Sangwan V, Banerjee S, Chugh R, Dudeja V, Vickers SM and Saluja AK: Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the death receptor pathway. Cancer Lett. 348:156–166. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Jiang X, Chen Y, Fan X, Zhang H and Kun L: Osteogenesis and mineralization in a rabbit mandibular distraction osteogenesis model is promoted by the human LMP-1 gene. J Orthop Res. 33:521–526. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Ishioka S, Sagae S, Ito E and Kudo R: Ultrastructural study of benign, low-malignant potential (LMP), and malignant ovarian tumors. Med Electron Microsc. 37:37–44. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Pan H, Li X, Wang J, Zhang K, Yang H, Li Z, Zheng Z and Liu H: LIM mineralization protein-1 enhances bone morphogenetic protein-2-mediated osteogenesis through activation of ERK1/2 MAPK pathway and upregulation of Runx2 transactivity. J Bone Miner Res. 30:1523–1535. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Aisa MC, Rahman S, Senin U, Maggio D and Russell RG: Cathepsin B activity in normal human osteoblast-like cells and human osteoblastic osteosarcoma cells (MG-63): Regulation by interleukin-1 beta and parathyroid hormone. Biochim Biophys Acta. 1290:29–36. 1996. View Article : Google Scholar : PubMed/NCBI

42 

Jiao WJ, Xu J, Pan H, Wang TY and Shen Y: Effect of endothelin-1 in esophageal squamous cell carcinoma invasion and its correlation with cathepsin B. World J Gastroenterol. 13:4002–4005. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Zhang Q and Chen L: Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway. Oncol Rep 36: 1499-1505, 2016.
APA
Zhao, X., Zhang, Q., & Chen, L. (2016). Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway. Oncology Reports, 36, 1499-1505. https://doi.org/10.3892/or.2016.4957
MLA
Zhao, X., Zhang, Q., Chen, L."Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway". Oncology Reports 36.3 (2016): 1499-1505.
Chicago
Zhao, X., Zhang, Q., Chen, L."Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway". Oncology Reports 36, no. 3 (2016): 1499-1505. https://doi.org/10.3892/or.2016.4957
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Zhang Q and Chen L: Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway. Oncol Rep 36: 1499-1505, 2016.
APA
Zhao, X., Zhang, Q., & Chen, L. (2016). Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway. Oncology Reports, 36, 1499-1505. https://doi.org/10.3892/or.2016.4957
MLA
Zhao, X., Zhang, Q., Chen, L."Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway". Oncology Reports 36.3 (2016): 1499-1505.
Chicago
Zhao, X., Zhang, Q., Chen, L."Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway". Oncology Reports 36, no. 3 (2016): 1499-1505. https://doi.org/10.3892/or.2016.4957
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