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Article

CCY-1a-E2 induces G2/M phase arrest and apoptotic cell death in HL-60 leukemia cells through cyclin-dependent kinase 1 signaling and the mitochondria-dependent caspase pathway

  • Authors:
    • Chin‑Fen Lin
    • Jai‑Sing Yang
    • Chingju Lin
    • Fuu‑Jen Tsai
    • Chi‑Cheng Lu
    • Miau‑Rong Lee
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, China Medical University, Taichung 404, Taiwan, R.O.C., Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan, R.O.C., Department of Physiology, China Medical University, Taichung 404, Taiwan, R.O.C., Human Genetic Center, China Medical University Hospital, Taichung 404, Taiwan, R.O.C., School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan, R.O.C.
  • Pages: 1633-1639
    |
    Published online on: July 25, 2016
       https://doi.org/10.3892/or.2016.4970
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Abstract

Our previous study demonstrated that 2-[(3-methoxybenzyl)oxy]benzaldehyde (CCY-1a-E2) is a potent compound that acts against multiple human leukemia cell lines. CCY-1a-E2 was also shown to have efficacious anti‑leukemic activity in vivo. However, the molecular mechanism of action of CCY‑1a‑E2 attributed to its anticancer effect remains poorly understood. In the present study, CCY‑1a‑E2 suppressed cell viability in multiple leukemia cell lines (HL‑60, K562, KG‑1 and KG‑1a) via inhibition of cell proliferation, cell cycle arrest and induction of apoptosis. CCY‑1a‑E2 exhibited a marked toxic effect on HL‑60 cells and displayed low cytotoxicity in normal human peripheral blood mononuclear cells (PBMCs). Results from flow cytometric analysis indicated that CCY‑1a‑E2 promoted G2/M phase arrest and promoted apoptosis in the HL‑60 cells. CCY‑1a‑E2 treatment upregulated cyclin B, cyclin‑dependent kinase 1 (CDK1), cell division cycle 25C (cdc25C) and p21 protein expression. CCY‑1a‑E2 caused apoptotic cell death and DNA fragmentation as determined by 4',6‑diamidino‑2‑phenylindole (DAPI) staining and DNA gel electrophoresis. Elevated activities of caspase‑8, ‑9 and ‑3 were observed during CCY‑1a‑E2‑induced cell apoptosis; their specific inhibitors were found to block CCY‑1a‑E2‑induced apoptosis, respectively. Moreover, CCY‑1a‑E2 time‑dependently disrupted the mitochondrial membrane potential (ΔΨm), and it enhanced the protein levels of Fas/CD95, cytochrome c, Bax, cleaved PARP, as well as attenuated Bcl‑2 expression in the HL‑60 cells. Our results provide direct evidence that supports the future potential therapeutic application of CCY-1a-E2 in leukemia.
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1 

Riether C, Schürch CM and Ochsenbein AF: Regulation of hematopoietic and leukemic stem cells by the immune system. Cell Death Differ. 22:187–198. 2015. View Article : Google Scholar :

2 

Lu CC, Yang JS, Chiang JH, Hour MJ, Lin KL, Lin JJ, Huang WW, Tsuzuki M, Lee TH and Chung JG: Novel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits leukemic mice. PLoS One. 7:e368312012. View Article : Google Scholar : PubMed/NCBI

3 

Wang W, Lv M, Zhao X and Zhang J: Developing a novel indolocarbazole as histone deacetylases inhibitor against leukemia cell lines. J Anal Methods Chem. 2015:6750532015. View Article : Google Scholar : PubMed/NCBI

4 

Maioral MF, Gaspar PC, Rosa Souza GR, Mascarello A, Chiaradia LD, Licínio MA, Moraes AC, Yunes RA, Nunes RJ and Santos-Silva MC: Apoptotic events induced by synthetic naphthylchalcones in human acute leukemia cell lines. Biochimie. 95:866–874. 2013. View Article : Google Scholar

5 

Padma VV: An overview of targeted cancer therapy. Biomedicine (Taipei). 5:192015. View Article : Google Scholar

6 

Yang JS, Hour MJ, Huang WW, Lin KL, Kuo SC and Chung JG: MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells. J Pharmacol Exp Ther. 334:477–488. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Kan SF, Huang WJ, Lin LC and Wang PS: Inhibitory effects of evodiamine on the growth of human prostate cancer cell line LNCaP. Int J Cancer. 110:641–651. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Murray AW: Recycling the cell cycle: Cyclins revisited. Cell. 116:221–234. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Timofeev O, Cizmecioglu O, Settele F, Kempf T and Hoffmann I: Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition. J Biol Chem. 285:16978–16990. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Castedo M, Perfettini JL, Roumier T and Kroemer G: Cyclin-dependent kinase-1: Linking apoptosis to cell cycle and mitotic catastrophe. Cell Death Differ. 9:1287–1293. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Yang JS, Hour MJ, Kuo SC, Huang LJ and Lee MR: Selective induction of G2/M arrest and apoptosis in HL-60 by a potent anticancer agent, HMJ-38. Anticancer Res. 24:1769–1778. 2004.PubMed/NCBI

12 

Elsayed YA and Sausville EA: Selected novel anticancer treatments targeting cell signaling proteins. Oncologist. 6:517–537. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Shah MA and Schwartz GK: Cell cycle-mediated drug resistance: An emerging concept in cancer therapy. Clin Cancer Res. 7:2168–2181. 2001.PubMed/NCBI

14 

Chan KS, Koh CG and Li HY: Mitosis-targeted anti-cancer therapies: Where they stand. Cell Death Dis. 3:e4112012. View Article : Google Scholar : PubMed/NCBI

15 

Lu CC, Yang JS, Chiang JH, Hour MJ, Lin KL, Lee TH and Chung JG: Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: Dissections of endoplasmic reticulum stress, mitochondrial dysfunction and tumor xenografts. Biochim Biophys Acta. 1840:2310–2320. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Chiang JH, Yang JS, Lu CC, Hour MJ, Chang SJ, Lee TH and Chung JG: Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulated Fas/death receptor signaling. Toxicol Appl Pharmacol. 269:150–162. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Chung JG, Yang JS, Huang LJ, Lee FY, Teng CM, Tsai SC, Lin KL, Wang SF and Kuo SC: Proteomic approach to studying the cytotoxicity of YC-1 on U937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice. Proteomics. 7:3305–3317. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Sanjiv K, Su TL, Suman S, Kakadiya R, Lai TC, Wang HY, Hsiao M and Lee TC: The novel DNA alkylating agent BO-1090 suppresses the growth of human oral cavity cancer in xenografted and orthotopic mouse models. Int J Cancer. 130:1440–1450. 2012. View Article : Google Scholar

19 

Lin C, Yang JS, Tsai SC, Lin CF and Lee MR: In vivo evaluation of the synthesized novel 2-benzyloxybenzaldehyde analog CCY-1a-E2 for the treatment of leukemia in the BALB/c mouse WEHI-3 allograft model. Oncol Lett. 5:777–782. 2013.PubMed/NCBI

20 

Chang C, Kuo S, Lin Y, Wang J and Huang L: Benzyloxybenzaldehyde analogues as novel adenylyl cyclase activators. Bioorg Med Chem Lett. 11:1971–1974. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Wang JP, Chang LC, Hsu MF, Huang LJ and Kuo SC: 2-Benzyloxy-benzaldehyde inhibits formyl-methionyl-leucyl-phenylalanine stimulation of phospholipase D activation in rat neutrophils. Biochim Biophys Acta. 1573:26–32. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Liao CL, Lai KC, Huang AC, Yang JS, Lin JJ, Wu SH, Gibson Wood W, Lin JG and Chung JG: Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. Food Chem Toxicol. 50:1734–1740. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Kao TC, Shyu MH and Yen GC: Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway. J Agric Food Chem. 57:754–761. 2009. View Article : Google Scholar

24 

Lu CC, Yang SH, Hsia SM, Wu CH and Yen GC: Inhibitory effects of Phyllanthus emblica L. on hepatic steatosis and liver fibrosis in vitro. J Funct Foods. 20:20–30. 2016. View Article : Google Scholar

25 

Chang PY, Peng SF, Lee CY, Lu CC, Tsai SC, Shieh TM, Wu TS, Tu MG, Chen MY and Yang JS: Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells. Int J Oncol. 43:1141–1150. 2013.PubMed/NCBI

26 

Lin CC, Chuang YJ, Yu CC, Yang JS, Lu CC, Chiang JH, Lin JP, Tang NY, Huang AC and Chung JG: Apigenin induces apoptosis through mitochondrial dysfunction in U-2 OS human osteosarcoma cells and inhibits osteosarcoma xenograft tumor growth in vivo. J Agric Food Chem. 60:11395–11402. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Lee CY, Chien YS, Chiu TH, Huang WW, Lu CC, Chiang JH and Yang JS: Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway. Oncol Rep. 28:1883–1888. 2012.PubMed/NCBI

28 

Wang JP, Chang LC, Kuan YH, Tsao LT, Huang LJ and Kuo SC: 2-Benzyloxybenzaldehyde inhibits formyl peptide-stimulated increase in intracellular Ca2+ in neutrophils mainly by blocking Ca2+ entry. Naunyn Schmiedebergs Arch Pharmacol. 370:353–360. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Pan SL, Guh JH, Huang YW, Chang YL, Chang CY, Huang LJ, Kuo SC and Teng CM: Inhibition of Ras-mediated cell proliferation by benzyloxybenzaldehyde. J Biomed Sci. 9:622–630. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Lavrik IN, Golks A and Krammer PH: Caspases: Pharmacological manipulation of cell death. J Clin Invest. 115:2665–2672. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Orrenius S: Reactive oxygen species in mitochondria-mediated cell death. Drug Metab Rev. 39:443–455. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Ho TF and Chang CC: A promising 'TRAIL' of tanshinones for cancer therapy. Biomedicine (Taipei). 5:232015. View Article : Google Scholar

33 

Kuo HM, Tsai HC, Lin YL, Yang JS, Huang AC, Yang MD, Hsu SC, Chung MC, Gibson Wood W and Chung JG: Mitochondrial-dependent caspase activation pathway is involved in baicalein-induced apoptosis in human hepatoma J5 cells. Int J Oncol. 35:717–724. 2009.PubMed/NCBI

34 

Strauss G, Westhoff MA, Fischer-Posovszky P, Fulda S, Schanbacher M, Eckhoff SM, Stahnke K, Vahsen N, Kroemer G and Debatin KM: 4-Hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 15:332–343. 2008. View Article : Google Scholar

35 

Tsai SC, Huang WW, Huang WC, Lu CC, Chiang JH, Peng SF, Chung JG, Lin YH, Hsu YM, Amagaya S, et al: ERK-modulated intrinsic signaling and G(2)/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells. Int J Oncol. 41:2065–2072. 2012.PubMed/NCBI

36 

Huang TT, Lin HC, Chen CC, Lu CC, Wei CF, Wu TS, Liu FG and Lai HC: Resveratrol induces apoptosis of human nasopharyngeal carcinoma cells via activation of multiple apoptotic pathways. J Cell Physiol. 226:720–728. 2011. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lin CF, Yang JS, Lin C, Tsai FJ, Lu CC and Lee MR: CCY-1a-E2 induces G2/M phase arrest and apoptotic cell death in HL-60 leukemia cells through cyclin-dependent kinase 1 signaling and the mitochondria-dependent caspase pathway. Oncol Rep 36: 1633-1639, 2016.
APA
Lin, C., Yang, J., Lin, C., Tsai, F., Lu, C., & Lee, M. (2016). CCY-1a-E2 induces G2/M phase arrest and apoptotic cell death in HL-60 leukemia cells through cyclin-dependent kinase 1 signaling and the mitochondria-dependent caspase pathway. Oncology Reports, 36, 1633-1639. https://doi.org/10.3892/or.2016.4970
MLA
Lin, C., Yang, J., Lin, C., Tsai, F., Lu, C., Lee, M."CCY-1a-E2 induces G2/M phase arrest and apoptotic cell death in HL-60 leukemia cells through cyclin-dependent kinase 1 signaling and the mitochondria-dependent caspase pathway". Oncology Reports 36.3 (2016): 1633-1639.
Chicago
Lin, C., Yang, J., Lin, C., Tsai, F., Lu, C., Lee, M."CCY-1a-E2 induces G2/M phase arrest and apoptotic cell death in HL-60 leukemia cells through cyclin-dependent kinase 1 signaling and the mitochondria-dependent caspase pathway". Oncology Reports 36, no. 3 (2016): 1633-1639. https://doi.org/10.3892/or.2016.4970
Copy and paste a formatted citation
x
Spandidos Publications style
Lin CF, Yang JS, Lin C, Tsai FJ, Lu CC and Lee MR: CCY-1a-E2 induces G2/M phase arrest and apoptotic cell death in HL-60 leukemia cells through cyclin-dependent kinase 1 signaling and the mitochondria-dependent caspase pathway. Oncol Rep 36: 1633-1639, 2016.
APA
Lin, C., Yang, J., Lin, C., Tsai, F., Lu, C., & Lee, M. (2016). CCY-1a-E2 induces G2/M phase arrest and apoptotic cell death in HL-60 leukemia cells through cyclin-dependent kinase 1 signaling and the mitochondria-dependent caspase pathway. Oncology Reports, 36, 1633-1639. https://doi.org/10.3892/or.2016.4970
MLA
Lin, C., Yang, J., Lin, C., Tsai, F., Lu, C., Lee, M."CCY-1a-E2 induces G2/M phase arrest and apoptotic cell death in HL-60 leukemia cells through cyclin-dependent kinase 1 signaling and the mitochondria-dependent caspase pathway". Oncology Reports 36.3 (2016): 1633-1639.
Chicago
Lin, C., Yang, J., Lin, C., Tsai, F., Lu, C., Lee, M."CCY-1a-E2 induces G2/M phase arrest and apoptotic cell death in HL-60 leukemia cells through cyclin-dependent kinase 1 signaling and the mitochondria-dependent caspase pathway". Oncology Reports 36, no. 3 (2016): 1633-1639. https://doi.org/10.3892/or.2016.4970
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