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September-2016 Volume 36 Issue 3

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Article

STC-1 expression is upregulated through an Akt/NF-κB-dependent pathway in triple-negative breast cancer cells

  • Authors:
    • Myeongjin Jeon
    • Jeonghun Han
    • Seok Jin Nam
    • Jeong Eon Lee
    • Sangmin Kim
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Samsung Medical Center, Seoul 06351, Republic of Korea
  • Pages: 1717-1722
    |
    Published online on: July 25, 2016
       https://doi.org/10.3892/or.2016.4972
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Abstract

Stanniocalcin-1 (STC-1) is a secreted glycoprotein and its expression is strongly correlated with cancer development. However, regulatory mechanism of STC-1 expression in breast cancer cells is not clear. In the present study, we investigated whether STC-1 acts as a prognostic factor in TNBC patients and the regulation of STC-1 expression in breast cancer cells. Basal levels of STC-1 were significantly higher in TNBC cells than in non-TNBC cells. Induction of STC-1 expression was also associated with poor relapse-free survival of TNBC patients. In addition, we verified the correlation between the invasiveness of TNBC cells and the STC-1 expression. We found that recombinant human STC-1 treatment increased the invasiveness of TNBC cells. In contrast, STC-1-induced cell invasiveness was completely inhibited by anti-STC-1 monoclonal antibody treatment. We found that the basal levels of STC-1 expression in TNBC cells were decreased by treatment with LY294002 or Bay11-7085, but not SB203580. In contrast, transcript levels of STC-1 and protein secretion were increased by constitutively active Akt (CA-Akt) or NF-κB overexpression in TNBC cells. Finally, we observed that phosphorylation of NF-κB was significantly increased by CA-Akt overexpression in TNBC cells. Taken together, elevated STC-1 expression is associated with poor clinical outcome in TNBC patients, and STC-1 is directly involved in the invasiveness of TNBC cells. STC-1 expression is upregulated through a PI-3K/Akt/NF-κB‑dependent signaling pathway in TNBC cells.
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1 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Carey L, Winer E, Viale G, Cameron D and Gianni L: Triple-negative breast cancer: Disease entity or title of convenience? Nat Rev Clin Oncol. 7:683–692. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Foulkes WD, Smith IE and Reis-Filho JS: Triple-negative breast cancer. N Engl J Med. 363:1938–1948. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Fulford LG, Reis-Filho JS, Ryder K, Jones C, Gillett CE, Hanby A, Easton D and Lakhani SR: Basal-like grade III invasive ductal carcinoma of the breast: Patterns of metastasis and long-term survival. Breast Cancer Res. 9:R42007. View Article : Google Scholar : PubMed/NCBI

5 

Dent R, Hanna WM, Trudeau M, Rawlinson E, Sun P and Narod SA: Pattern of metastatic spread in triple-negative breast cancer. Breast Cancer Res Treat. 115:423–428. 2009. View Article : Google Scholar

6 

Ismail-Khan R and Bui MM: A review of triple-negative breast cancer. Cancer Control. 17:173–176. 2010.PubMed/NCBI

7 

Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, Lickley LA, Rawlinson E, Sun P and Narod SA: Triple-negative breast cancer: Clinical features and patterns of recurrence. Clin Cancer Res. 13:4429–4434. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Cleator S, Heller W and Coombes RC: Triple-negative breast cancer: Therapeutic options. Lancet Oncol. 8:235–244. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Yoshiko Y and Aubin JE: Stanniocalcin 1 as a pleiotropic factor in mammals. Peptides. 25:1663–1669. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Chang AC, Jellinek DA and Reddel RR: Mammalian stanniocalcins and cancer. Endocr Relat Cancer. 10:359–373. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Olsen HS, Cepeda MA, Zhang QQ, Rosen CA, Vozzolo BL and Wagner GF: Human stanniocalcin: A possible hormonal regulator of mineral metabolism. Proc Natl Acad Sci USA. 93:1792–1796. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Stasko SE and Wagner GF: Stanniocalcin gene expression during mouse urogenital development: A possible role in mesenchymal-epithelial signalling. Dev Dyn. 220:49–59. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Zhang KZ, Westberg JA, Paetau A, von Boguslawsky K, Lindsberg P, Erlander M, Guo H, Su J, Olsen HS and Andersson LC: High expression of stanniocalcin in differentiated brain neurons. Am J Pathol. 153:439–445. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Tamura S, Oshima T, Yoshihara K, Kanazawa A, Yamada T, Inagaki D, Sato T, Yamamoto N, Shiozawa M, Morinaga S, et al: Clinical significance of STC1 gene expression in patients with colorectal cancer. Anticancer Res. 31:325–329. 2011.PubMed/NCBI

15 

Fang Z, Tian Z, Luo K, Song H and Yi J: Clinical significance of stanniocalcin expression in tissue and serum of gastric cancer patients. Chin J Cancer Res. 26:602–610. 2014.PubMed/NCBI

16 

Fujiwara Y, Sugita Y, Nakamori S, Miyamoto A, Shiozaki K, Nagano H, Sakon M and Monden M: Assessment of Stanniocalcin-1 mRNA as a molecular marker for micrometastases of various human cancers. Int J Oncol. 16:799–804. 2000.PubMed/NCBI

17 

Paulitschke V, Kunstfeld R, Mohr T, Slany A, Micksche M, Drach J, Zielinski C, Pehamberger H and Gerner C: Entering a new era of rational biomarker discovery for early detection of melanoma metastases: Secretome analysis of associated stroma cells. J Proteome Res. 8:2501–2510. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Law AY, Lai KP, Lui WC, Wan HT and Wong CK: Histone deacetylase inhibitor-induced cellular apoptosis involves stan-niocalcin-1 activation. Exp Cell Res. 314:2975–2984. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Lai KP, Law AY, Yeung HY, Lee LS, Wagner GF and Wong CK: Induction of stanniocalcin-1 expression in apoptotic human nasopharyngeal cancer cells by p53. Biochem Biophys Res Commun. 356:968–975. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Yeung HY, Lai KP, Chan HY, Mak NK, Wagner GF and Wong CK: Hypoxia-inducible factor-1-mediated activation of stanniocalcin-1 in human cancer cells. Endocrinology. 146:4951–4960. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Jeon M, Lee J, Nam SJ, Shin I, Lee JE and Kim S: Induction of fibronectin by HER2 overexpression triggers adhesion and invasion of breast cancer cells. Exp Cell Res. 333:116–126. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Du YZ, Gu XH, Li L and Gao F: The diagnostic value of circulating stanniocalcin-1 mRNA in non-small cell lung cancer. J Surg Oncol. 104:836–840. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Chang AC, Doherty J, Huschtscha LI, Redvers R, Restall C, Reddel RR and Anderson RL: STC1 expression is associated with tumor growth and metastasis in breast cancer. Clin Exp Metastasis. 32:15–27. 2015. View Article : Google Scholar

24 

Liu G, Yang G, Chang B, Mercado-Uribe I, Huang M, Zheng J, Bast RC, Lin SH and Liu J: Stanniocalcin 1 and ovarian tumorigenesis. J Natl Cancer Inst. 102:812–827. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Ismail RS, Baldwin RL, Fang J, Browning D, Karlan BY, Gasson JC and Chang DD: Differential gene expression between normal and tumor-derived ovarian epithelial cells. Cancer Res. 60:6744–6749. 2000.PubMed/NCBI

26 

Law AY, Ching LY, Lai KP and Wong CK: Identification and characterization of the hypoxia-responsive element in human stanniocalcin-1 gene. Mol Cell Endocrinol. 314:118–127. 2010. View Article : Google Scholar

27 

Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM and Donner DB: NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature. 401:82–85. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Sizemore N, Leung S and Stark GR: Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol Cell Biol. 19:4798–4805. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jeon M, Han J, Nam SJ, Lee JE and Kim S: STC-1 expression is upregulated through an Akt/NF-κB-dependent pathway in triple-negative breast cancer cells. Oncol Rep 36: 1717-1722, 2016.
APA
Jeon, M., Han, J., Nam, S.J., Lee, J.E., & Kim, S. (2016). STC-1 expression is upregulated through an Akt/NF-κB-dependent pathway in triple-negative breast cancer cells. Oncology Reports, 36, 1717-1722. https://doi.org/10.3892/or.2016.4972
MLA
Jeon, M., Han, J., Nam, S. J., Lee, J. E., Kim, S."STC-1 expression is upregulated through an Akt/NF-κB-dependent pathway in triple-negative breast cancer cells". Oncology Reports 36.3 (2016): 1717-1722.
Chicago
Jeon, M., Han, J., Nam, S. J., Lee, J. E., Kim, S."STC-1 expression is upregulated through an Akt/NF-κB-dependent pathway in triple-negative breast cancer cells". Oncology Reports 36, no. 3 (2016): 1717-1722. https://doi.org/10.3892/or.2016.4972
Copy and paste a formatted citation
x
Spandidos Publications style
Jeon M, Han J, Nam SJ, Lee JE and Kim S: STC-1 expression is upregulated through an Akt/NF-κB-dependent pathway in triple-negative breast cancer cells. Oncol Rep 36: 1717-1722, 2016.
APA
Jeon, M., Han, J., Nam, S.J., Lee, J.E., & Kim, S. (2016). STC-1 expression is upregulated through an Akt/NF-κB-dependent pathway in triple-negative breast cancer cells. Oncology Reports, 36, 1717-1722. https://doi.org/10.3892/or.2016.4972
MLA
Jeon, M., Han, J., Nam, S. J., Lee, J. E., Kim, S."STC-1 expression is upregulated through an Akt/NF-κB-dependent pathway in triple-negative breast cancer cells". Oncology Reports 36.3 (2016): 1717-1722.
Chicago
Jeon, M., Han, J., Nam, S. J., Lee, J. E., Kim, S."STC-1 expression is upregulated through an Akt/NF-κB-dependent pathway in triple-negative breast cancer cells". Oncology Reports 36, no. 3 (2016): 1717-1722. https://doi.org/10.3892/or.2016.4972
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