Overexpression of seven in absentia homolog 2 protein in human breast cancer tissues is associated with the promotion of tumor cell malignant behavior in in vitro

Sun,Jie; Zhang,Xiaojuan; Han,Yanchun; Zhen,Juan; Meng,Yuan; Song,Min

doi:10.3892/or.2016.4976

Overexpression of seven in absentia homolog 2 protein in human breast cancer tissues is associated with the promotion of tumor cell malignant behavior in in vitro

Authors:
- Jie Sun
- Xiaojuan Zhang
- Yanchun Han
- Juan Zhen
- Yuan Meng
- Min Song
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Affiliations: Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. China, Intensive Care Unit, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Pathology, Binzhou Medical University, Binzhou, Shandong 256603, P.R. China
Published online on: July 25, 2016 https://doi.org/10.3892/or.2016.4976
Pages: 1301-1312

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Abstract

Seven in absentia homolog 2 (SIAH2), a homologue of Drosophila seven in absentia (Sina), has emerged as an oncogene and plays important roles in cancer development and progression. This study further assessed the role of SIAH2 in breast cancer and the underlying molecular events. The data showed that SIAH2 protein was overexpressed in invasive breast cancer (IBC) compared to the expression noted in normal or ductal carcinoma in situ (DCIS) tissues, expression of which is associated with malignant behaviors. SIAH2 may function differently in different molecular subtypes (e.g., luminal- vs. basal-like type) of breast cancer. Manipulation of SIAH2 expression led to a ‘cross-talk’ of the ERK and PI3K pathway, which could be one of the mechanisms by which SIAH2 regulates viability, apoptosis, and invasion capacity in these breast cancer cell lines.

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