miR-124 inhibits proliferation and invasion of human retinoblastoma cells by targeting STAT3

Retraction in: /10.3892/or.2021.8193

  • Authors:
    • Shu Liu
    • Chunmei Hu
    • Yingxue Wang
    • Guang Shi
    • Yarong Li
    • Huang Wu
  • View Affiliations

  • Published online on: August 3, 2016     https://doi.org/10.3892/or.2016.4999
  • Pages: 2398-2404
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Abstract

A growing body of evidence suggests that microRNA-124 (miR-124) functions as tumor-suppressor, and involves in tumor initiation, development and metastasis in major classes of human cancers; however, the biological role and underlying molecular mechanism of miR-124 in retinoblastoma (RB) remain unknown. Therefore, we investigated the biological activity and underlying molecular mechanism of miR-124 in human retinoblastoma. In the present study, our results demonstrated the downregulation of miR-124 in RB tissues and RB cell lines compared with normal retinal tissues. The ectopic expression of miR-124 in the RB cell lines (Y79 and SO-RB50) suppresses cell proliferation, migration and invasion, induced cell apoptosis in vitro. Furthermore, signal transducer and activator of transcription 3 (STAT3) was identified as a new target of miR-124, and overexpression of miR-124 decreased STAT3 expression on mRNA level and protein level in human RB cells. We also found that STAT3 mRNA expression was upregulated and inversely correlated with miR-124 expression in the RB tissues (r=-0.683; P<0.001). Restoration of the expression of STAT3 rescues the effects induced by miR-124 in RB cells. The findings of the present study suggested that miR-124 functioned as tumor suppressor in RB, at least in part, by targeting STAT3, and that it could serve as a potential candidate for RB therapeutics.
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October-2016
Volume 36 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Liu S, Hu C, Wang Y, Shi G, Li Y and Wu H: miR-124 inhibits proliferation and invasion of human retinoblastoma cells by targeting STAT3 Retraction in /10.3892/or.2021.8193. Oncol Rep 36: 2398-2404, 2016.
APA
Liu, S., Hu, C., Wang, Y., Shi, G., Li, Y., & Wu, H. (2016). miR-124 inhibits proliferation and invasion of human retinoblastoma cells by targeting STAT3 Retraction in /10.3892/or.2021.8193. Oncology Reports, 36, 2398-2404. https://doi.org/10.3892/or.2016.4999
MLA
Liu, S., Hu, C., Wang, Y., Shi, G., Li, Y., Wu, H."miR-124 inhibits proliferation and invasion of human retinoblastoma cells by targeting STAT3 Retraction in /10.3892/or.2021.8193". Oncology Reports 36.4 (2016): 2398-2404.
Chicago
Liu, S., Hu, C., Wang, Y., Shi, G., Li, Y., Wu, H."miR-124 inhibits proliferation and invasion of human retinoblastoma cells by targeting STAT3 Retraction in /10.3892/or.2021.8193". Oncology Reports 36, no. 4 (2016): 2398-2404. https://doi.org/10.3892/or.2016.4999