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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October-2016 Volume 36 Issue 4

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Current treatments for advanced melanoma and introduction of a promising novel gene therapy for melanoma (Review)

Jae‑Rim Heo, Nam‑Hyung Kim, Jaejin Cho, Kyung‑Chul Choi
Pages: 1779-1786
Published online on: 24 August 2016

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Review Open Access

Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review)

Dragana Nikitovic, Rafaela‑Maria Kavasi, Aikaterini Berdiaki, Dionysios J. Papachristou, John Tsiaoussis, Demetrios A. Spandidos, Aristides M. Tsatsakis, George N. Tzanakakis
Pages: 1787-1792
Published online on: 01 August 2016

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Article Open Access

RNAi-mediated HOXD3 knockdown inhibits growth in human RKO cells

Fangjun Chen, Guoping Sun, Jun Peng
Pages: 1793-1798
Published online on: 02 August 2016

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Article Open Access

Schisandrin B inhibits cell proliferation and induces apoptosis in human cholangiocarcinoma cells

Xiaohui Yang, Shuai Wang, Yunchuan Mu, Yixiong Zheng
Pages: 1799-1806
Published online on: 02 August 2016

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Article Open Access

Crosstalk between Beclin-1-dependent autophagy and caspase‑dependent apoptosis induced by tanshinone IIA in human osteosarcoma MG-63 cells

Kun Ma, Chuan Zhang, Man-Yu Huang, Yan-Xing Guo, Guo-Qiang Hu
Pages: 1807-1818
Published online on: 04 August 2016

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Article Open Access

PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN

Jianbo Xiong, Zhengrong Li, Yang Zhang, Daojiang Li, Guoyang Zhang, Xianshi Luo, Zhigang Jie, Yi Liu, Yi Cao, Zhibiao Le, Shengxing Tan, Wenyu Zou, Peitao Gong, Lingyu Qiu, Yuanyuan Li, Huan Wang, Heping Chen
Pages: 1819-1828
Published online on: 23 August 2016

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Article Open Access

PTK7 overexpression in colorectal tumors: Clinicopathological correlation and prognosis relevance

Xiuyun Tian, Liang Yan, Donghai Zhang, Xiaoya Guan, Bin Dong, Min Zhao, Chunyi Hao
Pages: 1829-1836
Published online on: 28 July 2016

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Article Open Access

TGF-β1 regulating miR-205/miR-195 expression affects the TGF-β signal pathway by respectively targeting SMAD2/SMAD7

Yingjun Duan, Qianxue Chen
Pages: 1837-1844
Published online on: 17 August 2016

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Article

Circulating tumour cells as biomarkers for evaluating cryosurgery on unresectable hepatocellular carcinoma

Jian Shi, Yuan Li, Shuzhen Liang, Jianying Zeng, Guifeng Liu, Feng Mu, Haibo Li, Jibing Chen, Mao Lin, Shihou Sheng, Huaiyu Zhang, Tongjun Liu, Lizhi Niu
Pages: 1845-1851
Published online on: 25 August 2016

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Article Open Access

Decreased LIPF expression is correlated with DGKA and predicts poor outcome of gastric cancer

Yi Kong, Yan Zheng, Yanfei Jia, Ping Li, Yunshan Wang
Pages: 1852-1860
Published online on: 01 August 2016

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Article Open Access

Next generation deep sequencing identified a novel lncRNA n375709 associated with paclitaxel resistance in nasopharyngeal carcinoma

Shuling Ren, Guo Li, Chao Liu, Tao Cai, Zongwu Su, Ming Wei, Li She, Yongquan Tian, Yuanzheng Qiu, Xin Zhang, Yong Liu, Yunyun Wang
Pages: 1861-1867
Published online on: 28 July 2016

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Article Open Access

Expression pattern and methylation of estrogen receptor α in breast intraductal proliferative lesions

Xiaoyun Mao, Zhen Qiao, Chuifeng Fan, Ayao Guo, Xinmiao Yu, Feng Jin
Pages: 1868-1874
Published online on: 01 August 2016

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Article Open Access

Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells

Kouji Okada, Shuko Hakata, Jun Terashima, Toshie Gamou, Wataru Habano, Shogo Ozawa
Pages: 1875-1885
Published online on: 08 August 2016

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Article Open Access

Ultrasound-targeted microbubble destruction of calcium channel subunit α 1D siRNA inhibits breast cancer via G protein-coupled receptor 30

Yanlei Ji, Zhen Han, Limei Shao, Yuehuan Zhao
Pages: 1886-1892
Published online on: 23 August 2016

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Article

Metastasis-associated protein is a predictive biomarker for metastasis and recurrence in gastric cancer

Yoshinaga Okugawa, Yasuhiko Mohri, Koji Tanaka, Mikio Kawamura, Susumu Saigusa, Yuji Toiyama, Masaki Ohi, Yasuhiro Inoue, Chikao Miki, Masato Kusunoki
Pages: 1893-1900
Published online on: 25 August 2016

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Article

High expression of miR-15b predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy

Wen-Bin Ji, Xin Liu, Ying Luo, Wen-Zhi Zhang
Pages: 1901-1908
Published online on: 28 July 2016

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Article

Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, migration effects and accelerates cell cycle progression in multiple myeloma cells via activating the Akt pathway Corrigendum in /10.3892/or.2021.7923

Dong Zheng, Ziang Chen, Jingfu Chen, Xiaomin Zhuang, Jianqiang Feng, Juan Li
Pages: 1909-1916
Published online on: 11 August 2016

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Article

miR-145 suppresses colorectal cancer cell migration and invasion by targeting an ETS-related gene

Shuling Li, Xiaobing Wu, Yuandong Xu, Shangbiao Wu, Zhifa Li, Rong Chen, Nanqi Huang, Ziyuan Zhu, Xuehu Xu
Pages: 1917-1926
Published online on: 25 August 2016

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Article

RUNX3 plays an important role in As2O3‑induced apoptosis and allows cells to overcome MSC‑mediated drug resistance

Guo‑Zheng Pan, Feng‑Xian Zhai, Yin Lu, Zhi‑Gang Fang, Rui‑Fang Fan, Xiang‑Fu Liu, Dong‑Jun Lin
Pages: 1927-1938
Published online on: 05 August 2016

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Article

Suppression of CEP55 reduces cell viability and induces apoptosis in human lung cancer

Ligang Liu, Qi Mei, Jing Zhao, Yuhong Dai, Qiang Fu
Pages: 1939-1945
Published online on: 31 August 2016

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Article

Cortactin promotes cell migration and invasion through upregulation of the dedicator of cytokinesis 1 expression in human colorectal cancer

Xiaoqian Jing, Huo Wu, Xiaopin Ji, Haoxuan Wu, Minmin Shi, Ren Zhao
Pages: 1946-1952
Published online on: 31 August 2016

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Article

An integrin αvβ3 antagonistic modified peptide inhibits tumor growth through inhibition of the ERK and AKT signaling pathways

Lirong Hu, Jingjing Wang, Ying Wang, Hanmei Xu
Pages: 1953-1962
Published online on: 02 August 2016

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Article

Fucoidan inhibits angiogenesis induced by multiple myeloma cells

Fen Liu, Guoping Luo, Qing Xiao, Liping Chen, Xiaohua Luo, Jinglong Lv, Lixue Chen
Pages: 1963-1972
Published online on: 01 August 2016

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Article

Downregulation of DNA-PKcs suppresses P-gp expression via inhibition of the Akt/NF-κB pathway in CD133-positive osteosarcoma MG-63 cells

Ka Li, Xin Li, Jiguang Tian, Hongliang Wang, Jingbo Pan, Jianmin Li
Pages: 1973-1980
Published online on: 02 August 2016

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Article

Expression status of cyclase‑associated protein 2 as a prognostic marker for human breast cancer

Lihua Xu, Sida Peng, Qunai Huang, Yu Liu, Hua Jiang, Xi Li, Jiani Wang
Pages: 1981-1988
Published online on: 25 August 2016

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Article

JQ1, a small molecule inhibitor of BRD4, suppresses cell growth and invasion in oral squamous cell carcinoma

Limei Wang, Xiuyin Wu, Ping Huang, Zhijun Lv, Yuping Qi, Xiujuan Wei, Pishan Yang, Fenghe Zhang
Pages: 1989-1996
Published online on: 24 August 2016

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Article Open Access

Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia

Ming-Jenn Chen, Yi-Ling Chen, Tzu-Wen Wang, Hui-Ping Hsu, Ming-Derg Lai
Pages: 1997-2008
Published online on: 10 August 2016

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Article

Oleuropein inhibits the proliferation and invasion of glioma cells via suppression of the AKT signaling pathway

Ming Liu, Jian Wang, Bin Huang, Anjing Chen, Xingang Li
Pages: 2009-2016
Published online on: 28 July 2016

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Article

CCL22 and IL-37 inhibit the proliferation and epithelial-mesenchymal transition process of NSCLC A549 cells Corrigendum in /10.3892/or.2020.7903

Yu-Hua Chen, Bi-Yun Zhou, Xian-Jing Wu, Jun-Fa Xu, Jun‑Ai Zhang, Yong-Hua Chen, Si-Si Liang
Pages: 2017-2024
Published online on: 02 August 2016

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Article

Acidic extracellular pH promotes prostate cancer bone metastasis by enhancing PC-3 stem cell characteristics, cell invasiveness and VEGF-induced vasculogenesis of BM-EPCs

Sheng Huang, Yubo Tang, Xinsheng Peng, Xingdong Cai, Qingde Wa, Dong Ren, Qiji Li, Jiaquan Luo, Liangping Li, Xuenong Zou, Shuai Huang
Pages: 2025-2032
Published online on: 02 August 2016

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Article

Overexpression of long non-coding RNA MFI2 promotes cell proliferation and suppresses apoptosis in human osteosarcoma

Zhixun Yin, Hongmei Ding, Erming He, Jingmhen Chen, Ming Li
Pages: 2033-2040
Published online on: 11 August 2016

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Article

MicroRNA-181d is a tumor suppressor in human esophageal squamous cell carcinoma inversely regulating Derlin-1

Dejun Li, Mo Shi, Hongsheng Ji, Gang Chen, Hua Jiang, Zhou Wang
Pages: 2041-2048
Published online on: 22 August 2016

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Article

miR-451 suppresses bladder cancer cell migration and invasion via directly targeting c-Myc

Jun Wang, Xiaomei Zhao, Jianhua Shi, Yiwei Pan, Qinghai Chen, Pengfei Leng, Yan Wang
Pages: 2049-2058
Published online on: 25 August 2016

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Article

Anticancer effect of 20(S)-ginsenoside Rh2 on HepG2 liver carcinoma cells: Activating GSK-3β and degrading β-catenin

Qingqiang Shi, Xueping Shi, Gei Zuo, Wei Xiong, Haixing Li, Pei Guo, Fen Wang, Yi Chen, Jing Li, Di‑Long Chen
Pages: 2059-2070
Published online on: 24 August 2016

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Article

Depletion of SENP1 suppresses the proliferation and invasion of triple-negative breast cancer cells

Zhonghua Wang, Jia Jin, Jian Zhang, Leiping Wang, Jun Cao
Pages: 2071-2078
Published online on: 24 August 2016

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Article

MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541

Huan Wang, Mei Xiong, Yongwu Hu, Yusheng Sun, Qing Ma
Pages: 2079-2086
Published online on: 23 August 2016

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Article

AKT1 as the PageRank hub gene is associated with melanoma and its functional annotation is highly related to the estrogen signaling pathway that may regulate the growth of melanoma

Jingjing Zhao, Xue Zeng, Ping Song, Xiaohong Wu, Hongbo Shi
Pages: 2087-2093
Published online on: 25 August 2016

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Article

Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells

Yung-Luen Shih, Jason Chou, Ming-Yang Yeh, Hsiao-Min Chou, Hsiu-Chen Chou, Hsu-Feng Lu, Hung-Sheng Shang, Fu-Shin Chueh, Yung-Lin Chu, Shu-Ching Hsueh, Jing-Gung Chung
Pages: 2094-2100
Published online on: 17 August 2016

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Article

Overexpression of microRNA-497 suppresses cell proliferation and induces apoptosis through targeting paired box 2 in human ovarian cancer

Zhong Lin, Junling Zhao, Xindan Wang, Xuehong Zhu, Liansheng Gong
Pages: 2101-2107
Published online on: 11 August 2016

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Article

Epigenetically deregulated miR-200c is involved in a negative feedback loop with DNMT3a in gastric cancer cells

Yingfei Li, Yuqiang Nie, Sanfang Tu, Hong Wang, Yongjian Zhou, Yanlei Du, Jie Cao, Min Ye
Pages: 2108-2116
Published online on: 02 August 2016

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Article

Clinical significance of α‑ and β‑Klotho in urothelial carcinoma of the bladder

Shunta Hori, Makito Miyake, Sayuri Onishi, Yoshihiro Tatsumi, Yosuke Morizawa, Yasushi Nakai, Satoshi Anai, Nobumichi Tanaka, Kiyohide Fujimoto
Pages: 2117-2125
Published online on: 25 August 2016

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Article

An efficient and simple co-culture method for isolating primary human hepatic cells: Potential application for tumor microenvironment research

Wei Dong, Aiguo Lu, Jingkun Zhao, Shuai Yin, Baochi Ou, Hao Feng
Pages: 2126-2134
Published online on: 28 July 2016

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Article

MicroRNA-106a regulates phosphatase and tensin homologue expression and promotes the proliferation and invasion of ovarian cancer cells

Liang Chen, Fang Zhang, Xiu-Gui Sheng, Shi-Qian Zhang, Yue-Ting Chen, Bo-Wen Liu
Pages: 2135-2141
Published online on: 09 August 2016

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Article

Genome-wide profiling of chemoradiation‑induced changes in alternative splicing in colon cancer cells

Wei Xiong, Depei Gao, Yunfeng Li, Xin Liu, Peiling Dai, Jiyong Qin, Guanshun Wang, Kangming Li, Han Bai, Wenhui Li
Pages: 2142-2150
Published online on: 12 August 2016

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Article

Knockdown of FOXK1 alone or in combination with apoptosis-inducing 5-FU inhibits cell growth in colorectal cancer

Yao Wu, Ruyi Xie, Xuehua Liu, Jing Wang, Ying Peng, Weimei Tang, Meiyan Wu, Pei Zhang, Yang Ba, Jinjun Zhao, Aimin Li, Qingzhen Nan, Ye Chen, Side Liu, Jide Wang
Pages: 2151-2159
Published online on: 25 August 2016

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Article

Nitidine chloride inhibits the malignant behavior of human glioblastoma cells by targeting the PI3K/AKT/mTOR signaling pathway

Ming Liu, Jiwei Wang, Qichao Qi, Bin Huang, Anjing Chen, Xingang Li, Jian Wang
Pages: 2160-2168
Published online on: 03 August 2016

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Article

miR-15a induces cell apoptosis by targeting BCL2L2 and BCL2 in HPV-positive hypopharyngeal squamous cell carcinoma

Wuhao Lu, Long Feng, Yan Zhang, Yunyun Ma, Ping Li, Yuanyuan Wang, Yuwen Du, Xiaonan Chen, Shujun Wu, Guoqiang Zhao, Weihua Lou
Pages: 2169-2176
Published online on: 25 August 2016

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Article

miR-17 inhibits ovarian cancer cell peritoneal metastasis by targeting ITGA5 and ITGB1

Cheng Gong, Zongyuan Yang, Fenghua Wu, Lintao Han, Yi Liu, Wei Gong
Pages: 2177-2183
Published online on: 28 July 2016

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Article

Clinical effects of miR-101 on prognosis of hepatocellular carcinoma and carcinogenic mechanism of anti-miR-101

Xuecheng Lv, Jinghua Li, Bingnan Yang
Pages: 2184-2192
Published online on: 28 July 2016

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Article

Increased NEK2 in hepatocellular carcinoma promotes cancer progression and drug resistance by promoting PP1/Akt and Wnt activation

Sailan Wen, Yuwu Liu, Manyi Yang, Keda Yang, Jianghai Huang, Deyun Feng
Pages: 2193-2199
Published online on: 09 August 2016

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Article

Combination of nadroparin with radiotherapy results in powerful synergistic antitumor effects in lung adenocarcinoma A549 cells

Xibing Zhuang, Tiankui Qiao, Guoxiong Xu, Sujuan Yuan, Qi Zhang, Xue Chen
Pages: 2200-2206
Published online on: 01 August 2016

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Article

Curcumin causes DNA damage and affects associated protein expression in HeLa human cervical cancer cells

Hung-Sheng Shang, Chuan-Hsun Chang, Yu-Ru Chou, Ming-Yang Yeh, Man-Kuan Au, Hsu-Feng Lu, Yung-Lin Chu, Hsiao-Min Chou, Hsiu-Chen Chou, Yung-Luen Shih, Jing-Gung Chung
Pages: 2207-2215
Published online on: 04 August 2016

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Article

RLIP76 decreases apoptosis through Akt/mTOR signaling pathway in gastric cancer Corrigendum in /10.3892/or.2018.6314

Wenwen Wang, Juan Liu, Jianni Qi, Junyong Zhang, Qiang Zhu, Chengyong Qin
Pages: 2216-2224
Published online on: 25 August 2016

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Article

Methylation of the SEPT9_v2 promoter as a novel marker for the detection of circulating tumor DNA in breast cancer patients

Saki Matsui, Naofumi Kagara, Chieko Mishima, Yasuto Naoi, Masafumi Shimoda, Atsushi Shimomura, Kenzo Shimazu, Seung Jin Kim, Shinzaburo Noguchi
Pages: 2225-2235
Published online on: 04 August 2016

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Article

The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma

Zhenkuan Xu, Jie Gong, Chuanwei Wang, Yunyan Wang, Yan Song, Wenzhe Xu, Zhiguo Liu, Yuguang Liu
Pages: 2236-2244
Published online on: 25 August 2016

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Article

Curcumin inhibits H2O2-induced invasion and migration of human pancreatic cancer via suppression of the ERK/NF-κB pathway

Lei Cao, Jiangbo Liu, Lun Zhang, Xue Xiao, Wei Li
Pages: 2245-2251
Published online on: 25 August 2016

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Article

Identification of CD200+ colorectal cancer stem cells and their gene expression profile

Shan-Shan Zhang, Zai-Wei Huang, Li-Xuan Li, Jin-Jin Fu, Bing Xiao
Pages: 2252-2260
Published online on: 24 August 2016

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Article

Thymoquinone induces apoptosis through downregulation of c-FLIP and Bcl-2 in renal carcinoma Caki cells

Eun Jung Park, Anil Kumar Chauhan, Kyoung-Jin Min, Dong Cheol Park, Taeg Kyu Kwon
Pages: 2261-2267
Published online on: 12 August 2016

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Article

Non-thermal gas plasma-induced endoplasmic reticulum stress mediates apoptosis in human colon cancer cells

Madduma Hewage Susara Ruwan Kumara, Mei Jing Piao, Kyoung Ah Kang, Yea Seong Ryu, Jeong Eon Park, Kristina Shilnikova, Jin Oh Jo, Young Sun Mok, Jennifer H. Shin, Yeonsoo Park, Seong Bong Kim, Suk Jae Yoo, Jin Won Hyun
Pages: 2268-2274
Published online on: 24 August 2016

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Article

Overexpression of CXCR7 induces angiogenic capacity of human hepatocellular carcinoma cells via the AKT signaling pathway

Yuhui Chen, Fei Teng, Geying Wang, Zhiyu Nie
Pages: 2275-2281
Published online on: 25 August 2016

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Foxp3 downregulation in NSCLC mediates epithelial-mesenchymal transition via NF-κB signaling

Xi Wang, Ying Liu, Lingling Dai, Qi Liu, Liuqun Jia, Huan Wang, Lin An, Xiaogang Jing, Meng Liu, Pengfei Li, Zhe Cheng
Pages: 2282-2288
Published online on: 17 August 2016

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Use of rhenium-188 for in vivo imaging and treatment of human cervical cancer cells transfected with lentivirus expressing sodium iodide symporter

Min Zhang, Shuo Shi, Rui Guo, Yin Miao, Biao Li
Pages: 2289-2297
Published online on: 24 August 2016

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Article

Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures

Rosaria Acquaviva, Valeria Sorrenti, Rosa Santangelo, Venera Cardile, Barbara Tomasello, Giuseppe Malfa, Luca Vanella, Andrea Amodeo, Carlo Genovese, Silvana Mastrojeni, Michela Pugliese, Monica Ragusa, Claudia Di Giacomo
Pages: 2298-2304
Published online on: 24 August 2016

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Article

HBx-induced miR-21 suppresses cell apoptosis in hepatocellular carcinoma by targeting interleukin-12

Dian Yin, Yilang Wang, Wenli Sai, Liang Zhang, Yajun Miao, Lili Cao, Xiaolu Zhai, Xiu Feng, Li Yang
Pages: 2305-2312
Published online on: 17 August 2016

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Article

MicroRNA-892b influences proliferation, migration and invasion of bladder cancer cells by mediating the p19ARF/cyclin D1/CDK6 and Sp-1/MMP-9 pathways

Seung-Shick Shin, Sung-Soo Park, Byungdoo Hwang, Bokyung Moon, Won Tae Kim, Wun-Jae Kim, Sung-Kwon Moon
Pages: 2313-2320
Published online on: 25 August 2016

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Article

MicroRNA-124 inhibits proliferation, invasion, migration and epithelial-mesenchymal transition of cervical carcinoma cells by targeting astrocyte-elevated gene-1

Xia Zhang, Dajun Cai, Lihua Meng, Bing Wang
Pages: 2321-2328
Published online on: 17 August 2016

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Article

MicroRNA-140 represses glioma growth and metastasis by directly targeting ADAM9 Retraction in /10.3892/or.2024.8723

Xiaogang Liu, Shanjun Wang, Aiqin Yuan, Xunhui Yuan, Bing Liu
Pages: 2329-2338
Published online on: 08 August 2016

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Article

Overexpression of TRIB3 promotes angiogenesis in human gastric cancer

Shaoting Dong, Jianling Xia, Hongqiang Wang, Li Sun, Zhenzhen Wu, Jianping Bin, Yulin Liao, Nailin Li, Wangjun Liao
Pages: 2339-2348
Published online on: 11 August 2016

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Article

Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression

Xiang Zhang, Lijuan Wang, Yingmei Wang, Shenjia Shi, Huayu Zhu, Fengjin Xiao, Jing Yang, Angang Yang, Xiaoke Hao
Pages: 2349-2356
Published online on: 11 August 2016

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Article

Identification of brefelamide as a novel inhibitor of osteopontin that suppresses invasion of A549 lung cancer cells

Jing Zhang, Osamu Yamada, Shinya Kida, Yoshihisa Matsushita, Shinya Murase, Toshio Hattori, Yuzuru Kubohara, Haruhisa Kikuchi, Yoshiteru Oshima
Pages: 2357-2364
Published online on: 05 August 2016

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Article

Epigenetic modulation of AR gene expression in prostate cancer DU145 cells with the combination of sodium butyrate and 5'-Aza-2'-deoxycytidine

Barbora Fialova, Petra Luzna, Jan Gursky, Katerina Langova, Zdenek Kolar, Katerina Smesny Trtkova
Pages: 2365-2374
Published online on: 03 August 2016

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Article

miR‑1246 and miR‑4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer

Tatsuya Machida, Takaaki Tomofuji, Takayuki Maruyama, Toshiki Yoneda, Daisuke Ekuni, Tetsuji Azuma, Hisataka Miyai, Hirofumi Mizuno, Hironari Kato, Koichiro Tsutsumi, Daisuke Uchida, Akinobu Takaki, Hiroyuki Okada, Manabu Morita
Pages: 2375-2381
Published online on: 12 August 2016

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Article

Regulation of DEK expression by AP-2α and methylation level of DEK promoter in hepatocellular carcinoma

Ming-Xu Qiao, Chun Li, Ai-Qun Zhang, Ling-Ling Hou, Juan Yang, Hong-Gang Hu
Pages: 2382-2390
Published online on: 28 July 2016

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Upregulation of microRNA-34a enhances the DDP sensitivity of gastric cancer cells by modulating proliferation and apoptosis via targeting MET

Zhandong Zhang, Ye Kong, Wei Yang, Fei Ma, Yonglei Zhang, Sheqing Ji, Er-Min Ma, Hongxing Liu, Yongshun Chen, Yawei Hua
Pages: 2391-2397
Published online on: 11 August 2016

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Article

miR-124 inhibits proliferation and invasion of human retinoblastoma cells by targeting STAT3 Retraction in /10.3892/or.2021.8193

Shu Liu, Chunmei Hu, Yingxue Wang, Guang Shi, Yarong Li, Huang Wu
Pages: 2398-2404
Published online on: 03 August 2016

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Article

PIN1 in hepatocellular carcinoma is associated with TP53 gene status

Jun Sang Bae, Sang Jae Noh, Kyoung Min Kim, Kyu Yun Jang, Ho Sung Park, Myoung Ja Chung, Byung-Hyun Park, Woo Sung Moon
Pages: 2405-2411
Published online on: 04 August 2016

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Article

miR-194 is a negative regulator of GEF-H1 pathway in melanoma

Bingyu Guo, Qiang Hui, Yu Zhang, Peng Chang, Kai Tao
Pages: 2412-2420
Published online on: 12 August 2016

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Article

MicroRNA-106a suppresses proliferation, migration, and invasion of bladder cancer cells by modulating MAPK signaling, cell cycle regulators, and Ets-1-mediated MMP-2 expression

Seung-Shick Shin, Sung-Soo Park, Byungdoo Hwang, Won Tae Kim, Yung Hyun Choi, Wun-Jae Kim, Sung-Kwon Moon
Pages: 2421-2429
Published online on: 11 August 2016

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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