Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression

  • Authors:
    • Xiang Zhang
    • Lijuan Wang
    • Yingmei Wang
    • Shenjia Shi
    • Huayu Zhu
    • Fengjin Xiao
    • Jing Yang
    • Angang Yang
    • Xiaoke Hao
  • View Affiliations

  • Published online on: August 11, 2016     https://doi.org/10.3892/or.2016.5018
  • Pages: 2349-2356
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Forkhead box Q1 (FOXQ1) has been recognized as an oncogene that is overexpressed in different cancers, and several studies have shown that FOXQ1 is related to apoptosis and proliferation in many cancer types. However, the role and the molecular mechanism of FOXQ1 in prostate cancer remains unclear. In this study, we aimed to explore the role of FOXQ1 in regulating cell apoptosis, proliferation and invasion in prostate cancer and the underlying mechanism. We found that FOXQ1 was highly expressed in the prostate cancer tissues and cell lines. In our FOXQ1 loss-of-function experiments, the data indicate that the expression of BCL11A and MDM2 was significantly downregulated, prostate cancer cell proliferation and invasion were markedly suppressed, and apoptosis was significantly induced. Moreover, overexpression of BCL11A obviously reversed the effect of FOXQ1 inhibition on apoptosis, proliferation and invasion of prostate cancer cells. In addition, BCL11A overexpression also abrogated the inhibitory effect of FOXQ1 suppression on MDM2 expression. Taken together, our study suggests that FOXQ1 regulates prostate cancer cell proliferation and apoptosis by regulating BCL11A/MDM2 expression and indicates that FOXQ1 may serve as a potential therapeutic target for prostate cancer.
View Figures
View References

Related Articles

Journal Cover

October-2016
Volume 36 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Wang L, Wang Y, Shi S, Zhu H, Xiao F, Yang J, Yang A and Hao X: Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression. Oncol Rep 36: 2349-2356, 2016
APA
Zhang, X., Wang, L., Wang, Y., Shi, S., Zhu, H., Xiao, F. ... Hao, X. (2016). Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression. Oncology Reports, 36, 2349-2356. https://doi.org/10.3892/or.2016.5018
MLA
Zhang, X., Wang, L., Wang, Y., Shi, S., Zhu, H., Xiao, F., Yang, J., Yang, A., Hao, X."Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression". Oncology Reports 36.4 (2016): 2349-2356.
Chicago
Zhang, X., Wang, L., Wang, Y., Shi, S., Zhu, H., Xiao, F., Yang, J., Yang, A., Hao, X."Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression". Oncology Reports 36, no. 4 (2016): 2349-2356. https://doi.org/10.3892/or.2016.5018