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Article

MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3

Retraction in: /10.3892/or.2023.8541
  • Authors:
    • Huan Wang
    • Mei Xiong
    • Yongwu Hu
    • Yusheng Sun
    • Qing Ma
  • View Affiliations / Copyright

    Affiliations: Department of Medical Care Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Traumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
  • Pages: 2079-2086
    |
    Published online on: August 23, 2016
       https://doi.org/10.3892/or.2016.5029
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Abstract

Previous studies reported that the aberrant expression of miR-19b in gastric cancer tissues and circulating miR-19b is a potential biomarker to indicate progression of gastric cancer. However, the prognostic significance of miR-19b, and its role and underlying mechanisms in gastric cancer remain poorly investigated. In the present study, we demonstrated that the expression of miR-19b was aberrantly downregulated in both gastric cancer tissues and cell lines. Clinical association analyses disclosed that the reduced expression of miR-19b was significantly associated with adverse clinicopathological characteristics including poor differentiation, large tumor size and advanced tumor-node-metastasis (TNM) stage. Gastric cancer patients with low expression of miR-19b had prominent shorter overall survival and disease-free survival. Gain-of-function studies indicated that miR-19b overexpression inhibited cell proliferation and cell cycle progression in MGC-803 cells. While miR-19b silencing promoted cell proliferation and cell cycle progression in SGC-7901 cells. Furthermore, in vivo experiments showed that miR-19b overexpression suppressed the tumor growth of MGC-803 cells. Notably, miR-19b inversely regulated B-cell CLL/lymphoma 3 (BCL3) abundance in gastric cancer cells. BCL3 was identified as a direct target of miR-19b using luciferase reporter assays. Moreover, BCL3 knockdown abolished the effects of miR-19b knockdown on gastric cancer cells. In conclusion, our data suggest that miR-19b may potentially serve as a novel prognostic biomarker and therapeutic target for gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Xiong M, Hu Y, Sun Y and Ma Q: MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541. Oncol Rep 36: 2079-2086, 2016.
APA
Wang, H., Xiong, M., Hu, Y., Sun, Y., & Ma, Q. (2016). MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541. Oncology Reports, 36, 2079-2086. https://doi.org/10.3892/or.2016.5029
MLA
Wang, H., Xiong, M., Hu, Y., Sun, Y., Ma, Q."MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541". Oncology Reports 36.4 (2016): 2079-2086.
Chicago
Wang, H., Xiong, M., Hu, Y., Sun, Y., Ma, Q."MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541". Oncology Reports 36, no. 4 (2016): 2079-2086. https://doi.org/10.3892/or.2016.5029
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Xiong M, Hu Y, Sun Y and Ma Q: MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541. Oncol Rep 36: 2079-2086, 2016.
APA
Wang, H., Xiong, M., Hu, Y., Sun, Y., & Ma, Q. (2016). MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541. Oncology Reports, 36, 2079-2086. https://doi.org/10.3892/or.2016.5029
MLA
Wang, H., Xiong, M., Hu, Y., Sun, Y., Ma, Q."MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541". Oncology Reports 36.4 (2016): 2079-2086.
Chicago
Wang, H., Xiong, M., Hu, Y., Sun, Y., Ma, Q."MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Retraction in /10.3892/or.2023.8541". Oncology Reports 36, no. 4 (2016): 2079-2086. https://doi.org/10.3892/or.2016.5029
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