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Article

Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures

  • Authors:
    • Rosaria Acquaviva
    • Valeria Sorrenti
    • Rosa Santangelo
    • Venera Cardile
    • Barbara Tomasello
    • Giuseppe Malfa
    • Luca Vanella
    • Andrea Amodeo
    • Carlo Genovese
    • Silvana Mastrojeni
    • Michela Pugliese
    • Monica Ragusa
    • Claudia Di Giacomo
  • View Affiliations / Copyright

    Affiliations: Department of Drug Science, Biochemistry Section, University of Catania, I-95123 Catania, Italy, Department of Bio-medical Sciences, Physiology Section, University of Catania, I-95123 Catania, Italy, Department of Bio-medical Sciences, Microbiology Section, University of Catania, I-95123 Catania, Italy, Department of Veterinary Sciences, University of Messina, Polo Universitario dell'Annunziata, I-98168 Messina, Italy
  • Pages: 2298-2304
    |
    Published online on: August 24, 2016
       https://doi.org/10.3892/or.2016.5035
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Abstract

Cancers of the digestive tract, in particular colorectal cancer (CRC), are among those most responsive to dietary modification. Research has shown that approximately 75% of all sporadic cases of CRC are directly influenced by diet. Many natural compounds have been investigated for their potential usefulness as cancer chemopreventive agents as they have been thought to suppress carcinogenesis mainly during the initiation phase due to their radical scavenger activity. Since there is an increasing interest in the in vivo protective effects of natural compounds contained in plants against oxidative damage involved in several human diseases such as cancer, the aim of the present research was to test the effects of a Celtis aetnensis (Tornab.) Strobl twig extract on a human colon carcinoma cell line (Caco2). In order to elucidate the mechanisms of action of this extract, LDH release, GSH content, ROS levels, caspase-3 and γ-GCS expression were also evaluated. The results revealed that the Celtis aetnensis extract reduced the cell viability of the Caco2 cells inducing apoptosis at the lowest concentration and necrosis at higher dosages. In addition, this extract caused an increase in the levels of ROS, a decrease in RSH levels and in the expression of HO-1. The expression of γ-GCS was not modified in the Celtis aetnensis-treated Caco-2 cells. These results suggest an interference of this extract on the oxidant/antioxidant cell balance with consequent cell damage. The present study supports the growing body of data suggesting the bioactivities of Celtis aetnensis (Tornab.) Strobl and its potential impact on cancer therapy and on human health.
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1 

Moulton JE: Tumors of alimentary tract. Tumors in Domestic Animals. Moulton JE III: University of California Press; Berkeley: pp. 240–272. 1977

2 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Worldwide variations in colorectal cancer. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Center MM, Jemal A, Smith RA and Ward E: Worldwide variations in colorectal cancer. CA Cancer J Clin. 59:366–378. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Fung TT and Brown LS: Dietary patterns and the risk of colorectal cancer. Curr Nutr Rep. 2:48–55. 2013. View Article : Google Scholar :

5 

Armstrong B and Doll R: Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 15:617–631. 1975. View Article : Google Scholar : PubMed/NCBI

6 

Key TJ: Fruit and vegetables and cancer risk. Br J Cancer. 104:6–11. 2011. View Article : Google Scholar :

7 

World Cancer Research Fund and American Institute for Cancer Research: WCRF/AICR Systematic Literature Review Continuous Update Project Report: The Associations between Food. (Nutrition and Physical Activity and the Risk of Colorectal Cancer). 2011, http://www.wcrf.org/int/research-we-fund/cancer-prevention-recommendations/pant-foodsurisimplewww.wcrf.org/int/research-we-fund/cancer-prevention-recommendations/pant-foods. Access date: June 2015.

8 

Etkin NL: Medicinal cuisines: Diet and ethnopharmacology. Int J Pharmacogn. 34:313–326. 1996. View Article : Google Scholar

9 

Lee JE: Vitamin D and colorectal cancer prevention: A review of epidemiologic studies. Curr Nutr Rep. 2:27–36. 2013. View Article : Google Scholar

10 

Hwang BY, Chai HB, Kardono LBS, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM and Kinghorn AD: Cytotoxic triterpenes from the twigs of Celtis philippinensis. Phytochemistry. 62:197–201. 2003. View Article : Google Scholar

11 

Pignatti S: Flora d'Italia. Edagricole; Bologna: pp. 1221997

12 

Chari VM, Neelakantan S and Seshadri TR: Chemical components of Betula utilis and Celtis australis. Indian J Chem. 6:231–234. 1968.

13 

Borges FFV, Machado TC, Cunha KS, Pereira KC, Costa EA, De Paula JR and Chen-Chen L: Assessment of the cytotoxic, genotoxic, and antigenotoxic activities of Celtis iguanaea (Jacq) in mice. An Acad Bras Cienc. 85:955–964. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Santa-Cruz LH, Turner CE, Knapp JE, Schiff PL Jr and Slatkin DJ: Moretenol and other constituents of Celtis laevigata. Phytochemistry. 14:2532–2533. 1975. View Article : Google Scholar

15 

Adedapo AA, Jimoh FO, Afolayan AJ and Masika PJ: Antioxidant properties of the methanol extracts of the leaves and stems of Celtis africana. Rec Nat Prod. 3:23–31. 2009.

16 

El-Alfy TS, El-Gohary HM, Sokkar NM, Hosny M and Al-Mahdy DA: A new flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. leaves and potential antioxidant and cytotoxic activities. Sci Pharm. 79:963–975. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Weisburger JH: Antimutagenesis and anticarcinogenesis, from the past to the future. Mutat Res. 480–481:23–35. 2001. View Article : Google Scholar

18 

Balkwill F and Mantovani A: Inflammation and cancer: Back to Virchow? Lancet. 357:539–545. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Ohshima H, Tatemichi M and Sawa T: Chemical basis of inflammation-induced carcinogenesis. Arch Biochem Biophys. 417:3–11. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Acquaviva R, Campisi A, Murabito P, Raciti G, Avola R, Mangiameli S, Musumeci I, Barcellona ML, Vanella A and Li Volti G: Propofol attenuates peroxynitrite-mediated DNA damage and apoptosis in cultured astrocytes: An alternative protective mechanism. Anesthesiology. 101:1363–1371. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Acquaviva R, Di Giacomo C, Sorrenti V, Galvano F, Santangelo R, Cardile V, Gangia S, D'Orazio N, Abraham NG and Vanella L: Antiproliferative effect of oleuropein in prostate cell lines. Int J Oncol. 41:31–38. 2012.PubMed/NCBI

22 

Di Giacomo C, Acquaviva R, Sorrenti V, Vanella A, Grasso S, Barcellona ML, Galvano F, Vanella L and Renis M: Oxidative and antioxidant status in plasma of runners: effect of oral supplementation with natural antioxidants. J Med Food. 12:145–150. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254. 1976. View Article : Google Scholar : PubMed/NCBI

24 

Russo A, Borrelli F, Campisi A, Acquaviva R, Raciti G and Vanella A: nitric oxide-related toxicity in cultured astrocytes: Effect of Bacopa monniera. Life Sci. 73:1517–1526. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Li Volti G, Galvano F, Frigiola A, Guccione S, Di Giacomo C, Forte S, Tringali G, Caruso M, Adekoya OA and Gazzolo D: Potential immunoregulatory role of heme oxygenase-1 in human milk: A combined biochemical and molecular modeling approach. J Nutr Biochem. 21:865–871. 2010. View Article : Google Scholar

26 

Bastide P, Darido C, Pannequin J, Kist R, Robine S, Marty-Double C, Bibeau F, Scherer G, Joubert D, Hollande F, et al: Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium. J Cell Biol. 178:635–648. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Panza A, Pazienza V, Ripoli M, Benegiamo G, Gentile A, Valvano MR, Augello B, Merla G, Prattichizzo C, Tavano F, et al: Interplay between SOX9, β-catenin and PPARγ activation in colorectal cancer. Biochim Biophys Acta. 1833:1853–1865. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Fadeel B and Orrenius S: Apoptosis: A basic biological phenomenon with wide-ranging implications in human disease. J Intern Med. 258:479–517. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Tang WM, Chan E, Kwok CY, Lee YK, Wu JH, Wan CW, Chan RYK, Yu PHF and Chan SW: A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit. Inflammopharmacology. 20:307–314. 2012. View Article : Google Scholar

30 

Sarkar FH, Li Y, Wang Z and Kong D: Novel targets for prostate cancer chemoprevention. Endocr Relat Cancer. 17:R195–R212. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Reyes FJ, Centelles JJ, Lupiáñez JA and Cascante M: (2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. FEBS Lett. 580:6302–6310. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Liu J: Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol. 49:57–68. 1995. View Article : Google Scholar : PubMed/NCBI

33 

Murakami S, Takashima H, Sato-Watanabe M, Chonan S, Yamamoto K, Saitoh M, Saito S, Yoshimura H, Sugawara K, Yang J, et al: Ursolic acid, an antagonist for transforming growth factor (TGF)-beta1. FEBS Lett. 566:55–59. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Valko M, Rhodes CJ, Moncol J, Izakovic M and Mazur M: Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 160:1–40. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Conner EM and Grisham MB: Inflammation, free radicals, and antioxidants. Nutrition. 12:274–277. 1996. View Article : Google Scholar : PubMed/NCBI

36 

Wang SY and Jiao H: Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals, and singlet oxygen. J Agric Food Chem. 48:5677–5684. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Hirano T, Abe K, Gotoh M and Oka K: Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. Br J Cancer. 72:1380–1388. 1995. View Article : Google Scholar : PubMed/NCBI

38 

World Cancer Research Fund and American Institute for Cancer Research: Patterns of diet and cancer. Food, Nutrition and the Prevention of Cancer: A Global Perspective. American Institute for Cancer Research; Washington, DC: pp. 430–471. 1997

39 

Wlodek L and Steven HZ: Antioxidants, programmed cell death, and cancer. Nutr Res. 21:295–307. 2001. View Article : Google Scholar

40 

Choi AM and Alam J: Heme oxygenase-1: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol. 15:9–19. 1996. View Article : Google Scholar : PubMed/NCBI

41 

Camhi SL, Alam J, Wiegand GW, Chin BY and Choi AM: Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5′ distal enhancers: Role of reactive oxygen intermediates and AP-1. Am J Respir Cell Mol Biol. 18:226–234. 1998. View Article : Google Scholar : PubMed/NCBI

42 

Sunamura M, Duda DG, Ghattas MH, Lozonschi L, Motoi F, Yamauchi J, Matsuno S, Shibahara S and Abraham NG: Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer. Angiogenesis. 6:15–24. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Hill M, Pereira V, Chauveau C, Zagani R, Remy S, Tesson L, Mazal D, Ubillos L, Brion R, Asghar K, et al: Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: Mutual cross inhibition with indoleamine 2,3-dioxygenase. FASEB J. 19:1957–1968. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Yanagawa T, Omura K, Harada H, Nakaso K, Iwasa S, Koyama Y, Onizawa K, Yusa H and Yoshida H: Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas. Oral Oncol. 40:21–27. 2004. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Acquaviva R, Sorrenti V, Santangelo R, Cardile V, Tomasello B, Malfa G, Vanella L, Amodeo A, Genovese C, Mastrojeni S, Mastrojeni S, et al: Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures. Oncol Rep 36: 2298-2304, 2016.
APA
Acquaviva, R., Sorrenti, V., Santangelo, R., Cardile, V., Tomasello, B., Malfa, G. ... Di Giacomo, C. (2016). Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures. Oncology Reports, 36, 2298-2304. https://doi.org/10.3892/or.2016.5035
MLA
Acquaviva, R., Sorrenti, V., Santangelo, R., Cardile, V., Tomasello, B., Malfa, G., Vanella, L., Amodeo, A., Genovese, C., Mastrojeni, S., Pugliese, M., Ragusa, M., Di Giacomo, C."Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures". Oncology Reports 36.4 (2016): 2298-2304.
Chicago
Acquaviva, R., Sorrenti, V., Santangelo, R., Cardile, V., Tomasello, B., Malfa, G., Vanella, L., Amodeo, A., Genovese, C., Mastrojeni, S., Pugliese, M., Ragusa, M., Di Giacomo, C."Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures". Oncology Reports 36, no. 4 (2016): 2298-2304. https://doi.org/10.3892/or.2016.5035
Copy and paste a formatted citation
x
Spandidos Publications style
Acquaviva R, Sorrenti V, Santangelo R, Cardile V, Tomasello B, Malfa G, Vanella L, Amodeo A, Genovese C, Mastrojeni S, Mastrojeni S, et al: Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures. Oncol Rep 36: 2298-2304, 2016.
APA
Acquaviva, R., Sorrenti, V., Santangelo, R., Cardile, V., Tomasello, B., Malfa, G. ... Di Giacomo, C. (2016). Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures. Oncology Reports, 36, 2298-2304. https://doi.org/10.3892/or.2016.5035
MLA
Acquaviva, R., Sorrenti, V., Santangelo, R., Cardile, V., Tomasello, B., Malfa, G., Vanella, L., Amodeo, A., Genovese, C., Mastrojeni, S., Pugliese, M., Ragusa, M., Di Giacomo, C."Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures". Oncology Reports 36.4 (2016): 2298-2304.
Chicago
Acquaviva, R., Sorrenti, V., Santangelo, R., Cardile, V., Tomasello, B., Malfa, G., Vanella, L., Amodeo, A., Genovese, C., Mastrojeni, S., Pugliese, M., Ragusa, M., Di Giacomo, C."Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures". Oncology Reports 36, no. 4 (2016): 2298-2304. https://doi.org/10.3892/or.2016.5035
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