The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma

  • Authors:
    • Zhenkuan Xu
    • Jie Gong
    • Chuanwei Wang
    • Yunyan Wang
    • Yan Song
    • Wenzhe Xu
    • Zhiguo Liu
    • Yuguang Liu
  • View Affiliations

  • Published online on: August 25, 2016     https://doi.org/10.3892/or.2016.5046
  • Pages: 2236-2244
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Previous studies indicated that phosphoglycerate mutase 1 (PGAM1) is involved in many cancer types and promotes breast cancer progression. However, the role of PGAM1 in glioma remains unclear. The present study aimed to investigate the association of PGAM1 expression with glioma grade and the role of PGAM1 in proliferation, apoptosis, migration and invasion of glioma cells. The mRNA and protein expression of PGAM1 was analysed in glioma tissues and normal brain tissues. The expression of PGAM1 was examined further by immunohistochemical analysis. In addition, we inhibited the expression of PGAM1 in glioma cell line by siRNA to evaluate its role in glioma proliferation, apoptosis, migration and invasion. The mRNA and protein expression of PGAM1 was significantly greater in glioma than normal brain tissues. PGAM1 expression was associated with the WHO grade of glioma. siRNA knockdown of PGAM1 significantly inhibited glioma cell proliferation, promoted glioma cell apoptosis, induced S phase cell cycle arrest and inhibited glioma cell migration and invasion in vitro. PGAM1 may be associated with the grade of glioma and be involved in the biological behavior of glioma cells. PGAM1 might be a novel therapeutic target in glioma.
View Figures
View References

Related Articles

Journal Cover

October-2016
Volume 36 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xu Z, Gong J, Wang C, Wang Y, Song Y, Xu W, Liu Z and Liu Y: The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma. Oncol Rep 36: 2236-2244, 2016
APA
Xu, Z., Gong, J., Wang, C., Wang, Y., Song, Y., Xu, W. ... Liu, Y. (2016). The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma. Oncology Reports, 36, 2236-2244. https://doi.org/10.3892/or.2016.5046
MLA
Xu, Z., Gong, J., Wang, C., Wang, Y., Song, Y., Xu, W., Liu, Z., Liu, Y."The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma". Oncology Reports 36.4 (2016): 2236-2244.
Chicago
Xu, Z., Gong, J., Wang, C., Wang, Y., Song, Y., Xu, W., Liu, Z., Liu, Y."The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma". Oncology Reports 36, no. 4 (2016): 2236-2244. https://doi.org/10.3892/or.2016.5046