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Article

The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma

  • Authors:
    • Zhenkuan Xu
    • Jie Gong
    • Chuanwei Wang
    • Yunyan Wang
    • Yan Song
    • Wenzhe Xu
    • Zhiguo Liu
    • Yuguang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Qilu Hospital of Shandong University, Brain Science Research Institute of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Neurosurgery, Shandong Provincial Hospital affiliated to Shandong University, Shandong Cancer Hospital, Shandong Provincial Institute of Cancer Prevention and Treatment, Jinan, Shandong 250012, P.R. China
  • Pages: 2236-2244
    |
    Published online on: August 25, 2016
       https://doi.org/10.3892/or.2016.5046
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Abstract

Previous studies indicated that phosphoglycerate mutase 1 (PGAM1) is involved in many cancer types and promotes breast cancer progression. However, the role of PGAM1 in glioma remains unclear. The present study aimed to investigate the association of PGAM1 expression with glioma grade and the role of PGAM1 in proliferation, apoptosis, migration and invasion of glioma cells. The mRNA and protein expression of PGAM1 was analysed in glioma tissues and normal brain tissues. The expression of PGAM1 was examined further by immunohistochemical analysis. In addition, we inhibited the expression of PGAM1 in glioma cell line by siRNA to evaluate its role in glioma proliferation, apoptosis, migration and invasion. The mRNA and protein expression of PGAM1 was significantly greater in glioma than normal brain tissues. PGAM1 expression was associated with the WHO grade of glioma. siRNA knockdown of PGAM1 significantly inhibited glioma cell proliferation, promoted glioma cell apoptosis, induced S phase cell cycle arrest and inhibited glioma cell migration and invasion in vitro. PGAM1 may be associated with the grade of glioma and be involved in the biological behavior of glioma cells. PGAM1 might be a novel therapeutic target in glioma.
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View References

1 

Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, et al: Malignant astrocytic glioma: Genetics, biology, and paths to treatment. Genes Dev. 21:2683–2710. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Ostrom QT, Gittleman H, Farah P, Ondracek A, Chen Y, Wolinsky Y, Stroup NE, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006–2010. Neuro Oncol. 15(Suppl 2): ii1–ii56. 2013. View Article : Google Scholar :

3 

Sant M, Minicozzi P, Lagorio S, Børge Johannesen T, Marcos-Gragera R and Francisci S; EUROCARE Working Group: Survival of European patients with central nervous system tumors. Int J Cancer. 131:173–185. 2012. View Article : Google Scholar

4 

Evans MJ, Saghatelian A, Sorensen EJ and Cravatt BF: Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nat Biotechnol. 23:1303–1307. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Chen G, Gharib TG, Wang H, Huang CC, Kuick R, Thomas DG, Shedden KA, Misek DE, Taylor JM, Giordano TJ, et al: Protein profiles associated with survival in lung adenocarcinoma. Proc Natl Acad Sci USA. 100:13537–13542. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Narayanan NK, Narayanan BA and Nixon DW: Resveratrol-induced cell growth inhibition and apoptosis is associated with modulation of phosphoglycerate mutase B in human prostate cancer cells: Two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry evaluation. Cancer Detect Prev. 28:443–452. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Ren F, Wu H, Lei Y, Zhang H, Liu R, Zhao Y, Chen X, Zeng D, Tong A, Chen L, et al: Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. Mol Cancer. 9:812010. View Article : Google Scholar : PubMed/NCBI

8 

Liu L, Wang S, Zhang Q and Ding Y: Identification of potential genes/proteins regulated by Tiam1 in colorectal cancer by microarray analysis and proteome analysis. Cell Biol Int. 32:1215–1222. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Turhani D, Krapfenbauer K, Thurnher D, Langen H and Fountoulakis M: Identification of differentially expressed, tumor-associated proteins in oral squamous cell carcinoma by proteomic analysis. Electrophoresis. 27:1417–1423. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Fang MZ, Liu C, Song Y, Yang GY, Nie Y, Liao J, Zhao X, Shimada Y, Wang LD and Yang CS: Overexpression of gastrin-releasing peptide in human esophageal squamous cell carcinomas. Carcinogenesis. 25:865–871. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Tong A, Wu L, Lin Q, Lau QC, Zhao X, Li J, Chen P, Chen L, Tang H, Huang C, et al: Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model. Proteomics. 8:2012–2023. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Zhang S, Zhao Y, Lei B, Li C and Mao X: PGAM1 is involved in spermatogenic dysfunction and affects cell proliferation, apoptosis, and migration. Reprod Sci. 22:1236–1242. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Engel M, Mazurek S, Eigenbrodt E and Welter C: Phosphoglycerate mutase-derived polypeptide inhibits glycolytic flux and induces cell growth arrest in tumor cell lines. J Biol Chem. 279:35803–35812. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system (vol 114, pg 97, 2007). Acta Neuropathol. 114:547. 2007. View Article : Google Scholar

15 

Wen PY and Kesari S: Malignant gliomas in adults. N Engl J Med. 359:492–507. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Weller M, van den Bent M, Hopkins K, Tonn JC, Stupp R, Falini A, Cohen-Jonathan-Moyal E, Frappaz D, Henriksson R, Balana C, et al European Association for Neuro-Oncology (EANO) Task Force on Malignant Glioma: EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma. Lancet Oncol. 15:e395–e403. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Warburg O: On the origin of cancer cells. Science. 123:309–314. 1956. View Article : Google Scholar : PubMed/NCBI

18 

Kroemer G and Pouyssegur J: Tumor cell metabolism: Cancer's Achilles' heel. Cancer Cell. 13:472–482. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Ortega AD, Sánchez-Aragó M, Giner-Sánchez D, Sánchez-Cenizo L, Willers I and Cuezva JM: Glucose avidity of carcinomas. Cancer Lett. 276:125–135. 2009. View Article : Google Scholar

20 

Moreno-Sánchez R, Rodríguez-Enríquez S, Marín-Hernández A and Saavedra E: Energy metabolism in tumor cells. FEBS J. 274:1393–1418. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Altenberg B and Greulich KO: Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics. 84:1014–1020. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Amann T, Maegdefrau U, Hartmann A, Agaimy A, Marienhagen J, Weiss TS, Stoeltzing O, Warnecke C, Schölmerich J, Oefner PJ, et al: GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis. Am J Pathol. 174:1544–1552. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Meadows AL, Kong B, Berdichevsky M, Roy S, Rosiva R, Blanch HW and Clark DS: Metabolic and morphological differences between rapidly proliferating cancerous and normal breast epithelial cells. Biotechnol Prog. 24:334–341. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Ozbudak IH, Shilo K, Tavora F, Rassaei N, Chu WS, Fukuoka J, Jen J, Travis WD and Franks TJ: Glucose transporter-1 in pulmonary neuroendocrine carcinomas: Expression and survival analysis. Mod Pathol. 22:633–638. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Boag JM, Beesley AH, Firth MJ, Freitas JR, Ford J, Hoffmann K, Cummings AJ, de Klerk NH and Kees UR: Altered glucose metabolism in childhood pre-B acute lymphoblastic leukaemia. Leukemia. 20:1731–1737. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Mao P, Joshi K, Li J, Kim SH, Li P, Santana-Santos L, Luthra S, Chandran UR, Benos PV, Smith L, et al: Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3. Proc Natl Acad Sci USA. 110:8644–8649. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Feichtinger RG, Weis S, Mayr JA, Zimmermann F, Geilberger R, Sperl W and Kofler B: Alterations of oxidative phosphorylation complexes in astrocytomas. Glia. 62:514–525. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Bögler O, Huang HJ, Kleihues P and Cavenee WK: The p53 gene and its role in human brain tumors. Glia. 15:308–327. 1995. View Article : Google Scholar : PubMed/NCBI

29 

Ma W, Sung HJ, Park JY, Matoba S and Hwang PM: A pivotal role for p53: Balancing aerobic respiration and glycolysis. J Bioenerg Biomembr. 39:243–246. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F and Hwang PM: p53 regulates mitochondrial respiration. Science. 312:1650–1653. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV and Semenza GL: HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 11:407–420. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Astuti D, Latif F, Dallol A, Dahia PL, Douglas F, George E, Sköldberg F, Husebye ES, Eng C and Maher ER: Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet. 69:49–54. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Pelicano H, Martin DS, Xu RH and Huang P: Glycolysis inhibition for anticancer treatment. Oncogene. 25:4633–4646. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Inoki K, Zhu T and Guan KL: TSC2 mediates cellular energy response to control cell growth and survival. Cell. 115:577–590. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Grisolia S and Cleland WW: Influence of salt, substrate, and cofactor concentrations on the kinetic and mechanistic behavior of phosphoglycerate mutase. Biochemistry. 7:1115–1121. 1968. View Article : Google Scholar : PubMed/NCBI

36 

Hitosugi T, Zhou L, Elf S, Fan J, Kang HB, Seo JH, Shan C, Dai Q, Zhang L, Xie J, et al: Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 22:585–600. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Hitosugi T, Zhou L, Fan J, Elf S, Zhang L, Xie J, Wang Y, Gu TL, Alečković M, LeRoy G, et al: Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nat Commun. 4:17902013. View Article : Google Scholar : PubMed/NCBI

38 

Sanzey M, Abdul Rahim SA, Oudin A, Dirkse A, Kaoma T, Vallar L, Herold-Mende C, Bjerkvig R, Golebiewska A and Niclou SP: Comprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of glioblastoma. PLoS One. 10:1020152015. View Article : Google Scholar

39 

Gao H, Yu B, Yan Y, Shen J, Zhao S, Zhu J, Qin W and Gao Y: Correlation of expression levels of ANXA2, PGAM1, and CALR with glioma grade and prognosis. J Neurosurg. 118:846–853. 2013. View Article : Google Scholar

40 

Louis DN: Molecular pathology of malignant gliomas. Annu Rev Pathol. 1:97–117. 2006. View Article : Google Scholar

41 

Giese A, Bjerkvig R, Berens ME and Westphal M: Cost of migration: Invasion of malignant gliomas and implications for treatment. J Clin Oncol. 21:1624–1636. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu Z, Gong J, Wang C, Wang Y, Song Y, Xu W, Liu Z and Liu Y: The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma. Oncol Rep 36: 2236-2244, 2016.
APA
Xu, Z., Gong, J., Wang, C., Wang, Y., Song, Y., Xu, W. ... Liu, Y. (2016). The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma. Oncology Reports, 36, 2236-2244. https://doi.org/10.3892/or.2016.5046
MLA
Xu, Z., Gong, J., Wang, C., Wang, Y., Song, Y., Xu, W., Liu, Z., Liu, Y."The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma". Oncology Reports 36.4 (2016): 2236-2244.
Chicago
Xu, Z., Gong, J., Wang, C., Wang, Y., Song, Y., Xu, W., Liu, Z., Liu, Y."The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma". Oncology Reports 36, no. 4 (2016): 2236-2244. https://doi.org/10.3892/or.2016.5046
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Z, Gong J, Wang C, Wang Y, Song Y, Xu W, Liu Z and Liu Y: The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma. Oncol Rep 36: 2236-2244, 2016.
APA
Xu, Z., Gong, J., Wang, C., Wang, Y., Song, Y., Xu, W. ... Liu, Y. (2016). The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma. Oncology Reports, 36, 2236-2244. https://doi.org/10.3892/or.2016.5046
MLA
Xu, Z., Gong, J., Wang, C., Wang, Y., Song, Y., Xu, W., Liu, Z., Liu, Y."The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma". Oncology Reports 36.4 (2016): 2236-2244.
Chicago
Xu, Z., Gong, J., Wang, C., Wang, Y., Song, Y., Xu, W., Liu, Z., Liu, Y."The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma". Oncology Reports 36, no. 4 (2016): 2236-2244. https://doi.org/10.3892/or.2016.5046
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