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Article

Cortactin promotes cell migration and invasion through upregulation of the dedicator of cytokinesis 1 expression in human colorectal cancer

  • Authors:
    • Xiaoqian Jing
    • Huo Wu
    • Xiaopin Ji
    • Haoxuan Wu
    • Minmin Shi
    • Ren Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China
  • Pages: 1946-1952
    |
    Published online on: August 31, 2016
       https://doi.org/10.3892/or.2016.5058
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Abstract

Cortactin (CTTN), a major substrate of the Src tyrosine kinase, has been implicated in cell proliferation, motility and invasion in various types of cancer. However, the molecular mechanisms of CTTN-driven malignant behavior remain unclear. In the current study, we determined the expression of CTTN in colorectal cancer and investigated its underlying mechanism in the metastasis of colorectal cancer. We confirmed increased CTTN expression in lymph node-positive CRC specimens and highly invasive CRC cell lines. Further study has shown that overexpression of CTTN promoted CRC cell migration and invasion, whereas CTTN silencing inhibited CRC cell migratory and invasive capacities in vitro. Mechanistically, CTTN increases expression of dedicator of cytokinesis 1 (DOCK1) and gene silencing of DOCK1 partially abolishes the migration and invasion capacity by CTTN. Our findings indicate that CTTN promotes metastasis of CRC cells by increasing DOCK1 expression and this could offer a promising therapeutic target for colorectal cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Jing X, Wu H, Ji X, Wu H, Shi M and Zhao R: Cortactin promotes cell migration and invasion through upregulation of the dedicator of cytokinesis 1 expression in human colorectal cancer. Oncol Rep 36: 1946-1952, 2016.
APA
Jing, X., Wu, H., Ji, X., Wu, H., Shi, M., & Zhao, R. (2016). Cortactin promotes cell migration and invasion through upregulation of the dedicator of cytokinesis 1 expression in human colorectal cancer. Oncology Reports, 36, 1946-1952. https://doi.org/10.3892/or.2016.5058
MLA
Jing, X., Wu, H., Ji, X., Wu, H., Shi, M., Zhao, R."Cortactin promotes cell migration and invasion through upregulation of the dedicator of cytokinesis 1 expression in human colorectal cancer". Oncology Reports 36.4 (2016): 1946-1952.
Chicago
Jing, X., Wu, H., Ji, X., Wu, H., Shi, M., Zhao, R."Cortactin promotes cell migration and invasion through upregulation of the dedicator of cytokinesis 1 expression in human colorectal cancer". Oncology Reports 36, no. 4 (2016): 1946-1952. https://doi.org/10.3892/or.2016.5058
Copy and paste a formatted citation
x
Spandidos Publications style
Jing X, Wu H, Ji X, Wu H, Shi M and Zhao R: Cortactin promotes cell migration and invasion through upregulation of the dedicator of cytokinesis 1 expression in human colorectal cancer. Oncol Rep 36: 1946-1952, 2016.
APA
Jing, X., Wu, H., Ji, X., Wu, H., Shi, M., & Zhao, R. (2016). Cortactin promotes cell migration and invasion through upregulation of the dedicator of cytokinesis 1 expression in human colorectal cancer. Oncology Reports, 36, 1946-1952. https://doi.org/10.3892/or.2016.5058
MLA
Jing, X., Wu, H., Ji, X., Wu, H., Shi, M., Zhao, R."Cortactin promotes cell migration and invasion through upregulation of the dedicator of cytokinesis 1 expression in human colorectal cancer". Oncology Reports 36.4 (2016): 1946-1952.
Chicago
Jing, X., Wu, H., Ji, X., Wu, H., Shi, M., Zhao, R."Cortactin promotes cell migration and invasion through upregulation of the dedicator of cytokinesis 1 expression in human colorectal cancer". Oncology Reports 36, no. 4 (2016): 1946-1952. https://doi.org/10.3892/or.2016.5058
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