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Article

FoxO3a mediates glioma cell invasion by regulating MMP9 expression

  • Authors:
    • Ke Xu
    • Hua Pei
    • Zhenhao Zhang
    • Sufang Dong
    • Rui-Jia Fu
    • Wen-Ming Wang
    • Huamin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, School of Tropical and Laboratory Medicine, Hainan Medical University, Haikou, Hainan 571101, P.R. China, Medical Technology Institute of Xuzhou Medical College, Xuzhou, Jiangsu 221004, P.R. China, School of Tropical and Laboratory Medicine, Hainan Medical University, Haikou, Hainan 571101, P.R. China
  • Pages: 3044-3050
    |
    Published online on: September 12, 2016
       https://doi.org/10.3892/or.2016.5087
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Abstract

The role of FoxO3a in glioma progression is poorly defined. Herein, we show that silencing FoxO3a in U251 cells leads to decreased invasive migration and proliferation, while ectopic expression of FoxO3a in U87 cells with weak endogenous FoxO3a protein levels enhances invasion and proliferation. To further investigate the mechanism by which FoxO3a promotes invasion, we detected key members of the matrix metalloproteinases (MMPs) that are associated with invasion. Our findings showed that, among these MMP members, only FoxO3a induced MMP9 expression, and MMP9 overexpression reversed the effect that silencing FoxO3a had on the attenuation of cell invasion. Taken together, these data link FoxO3a to the promotion of metastasis in glioma cells.
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1 

Ohgaki H: Genetic pathways to glioblastomas. Neuropathology. 25:1–7. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Hou LC, Veeravagu A, Hsu AR and Tse VC: Recurrent glioblastoma multiforme: A review of natural history and management options. Neurosurg Focus. 20:E52006. View Article : Google Scholar : PubMed/NCBI

3 

Friedl P and Alexander S: Cancer invasion and the microenvironment: Plasticity and reciprocity. Cell. 147:992–1009. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Tonn JC and Goldbrunner R: Mechanisms of glioma cell invasion. Local Therapies for Glioma Present Status and Future Developments. Springer; pp. 163–167. 2003, View Article : Google Scholar

5 

Fu Z and Tindall DJ: FOXOs, cancer and regulation of apoptosis. Oncogene. 27:2312–2319. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Hu M, Lee D, Xia W, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, et al: IkappaB kinase promotes tumourigenesis through inhibition of Forkhead transcription factor FOXO3a. Cell. 117:225–237. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Yang J-Y, Chang C-J, Xia W, Wang Y, Wong KK, Engelman JA, Du Y, Andreeff M, Hortobagyi GN and Hung MC: Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. Cancer Res. 70:4709–4718. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Chen J, Gomes AR, Monteiro LJ, Wong SY, Wu LH, Ng TT, Karadedou CT, Millour J, Ip YC, Cheung YN, et al: Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer. PLoS One. 5:e122932010. View Article : Google Scholar : PubMed/NCBI

9 

Lam M, Carmichael AR and Griffiths HR: An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression. PLoS One. 7:e401522012. View Article : Google Scholar : PubMed/NCBI

10 

Shukla S, Bhaskaran N, Maclennan GT and Gupta S: Deregulation of FoxO3a accelerates prostate cancer progression in TRAMP mice. Prostate. 73:1507–1517. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Shukla S, Bhaskaran N, Babcook MA, Fu P, Maclennan GT and Gupta S: Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway. Carcinogenesis. 35:452–460. 2014. View Article : Google Scholar :

12 

Chen Q, Ganapathy S, Singh KP, Shankar S and Srivastava RK: Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One. 5:e152882010. View Article : Google Scholar : PubMed/NCBI

13 

Sunayama J, Sato A, Matsuda K, Tachibana K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K, et al: FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity. Stem Cells. 29:1327–1337. 2011.PubMed/NCBI

14 

Wang W, Li N-N, Du Y, Lv F-F and Lin G-Q: FoxO3a and nilotinib-induced erythroid differentiation of CML-BC cells. Leuk Res. 37:1309–1314. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Ruvolo PP: The Herculean task of killing cancer cells: Suppression of FOXO3A in acute leukemia involves a hydra of multiple survival kinases. Cell Cycle. 11:2589. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Kops GJ, Medema RH, Glassford J, Essers MA, Dijkers PF, Coffer PJ, Lam EW and Burgering BM: Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol Cell Biol. 22:2025–2036. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Hauck L, Harms C, Grothe D, An J, Gertz K, Kronenberg G, Dietz R, Endres M and von Harsdorf R: Critical role for FoxO3a-dependent regulation of p21CIP1/WAF1 in response to statin signaling in cardiac myocytes. Circ Res. 100:50–60. 2007. View Article : Google Scholar

18 

Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H and Komuro I: Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J. 23:212–220. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Rathbone CR, Booth FW and Lees SJ: FoxO3a preferentially induces p27Kip1 expression while impairing muscle precursor cell-cycle progression. Muscle Nerve. 37:84–89. 2008. View Article : Google Scholar

20 

Roy SK, Chen Q, Fu J, Shankar S and Srivastava RK: Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors. PLoS One. 6:e251662011. View Article : Google Scholar : PubMed/NCBI

21 

Obexer P, Geiger K, Ambros PF, Meister B and Ausserlechner MJ: FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death Differ. 14:534–547. 2007. View Article : Google Scholar

22 

Storz P, Döppler H, Copland JA, Simpson KJ and Toker A: FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases. Mol Cell Biol. 29:4906–4917. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Tenbaum SP, Ordóñez-Morán P, Puig I, Chicote I, Arqués O, Landolfi S, Fernández Y, Herance JR, Gispert JD, Mendizabal L, et al: β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Nat Med. 18:892–901. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Osuka S, Sampetrean O, Shimizu T, Saga I, Onishi N, Sugihara E, Okubo J, Fujita S, Takano S, Matsumura A, et al: IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells. Stem Cells. 31:627–640. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Ling N, Gu J, Lei Z, Li M, Zhao J, Zhang HT and Li X: microRNA-155 regulates cell proliferation and invasion by targeting FOXO3a in glioma. Oncol Rep. 30:2111–2118. 2013.PubMed/NCBI

26 

Deryugina EI and Quigley JP: Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev. 25:9–34. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Troussard AA, Costello P, Yoganathan TN, Kumagai S, Roskelley CD and Dedhar S: The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Oncogene. 19:5444–5452. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Kupferman ME, Fini ME, Muller WJ, Weber R, Cheng Y and Muschel RJ: Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression. Am J Pathol. 157:1777–1783. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Rao JS, Yamamoto M, Mohaman S, Gokaslan ZL, Fuller GN, Stetler-Stevenson WG, Rao VH, Liotta LA, Nicolson GL and Sawaya RE: Expression and localization of 92 kDa type IV collagenase/gelatinase B (MMP-9) in human gliomas. Clin Exp Metastasis. 14:12–18. 1996. View Article : Google Scholar : PubMed/NCBI

30 

Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A and Weinberg RA: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 117:927–939. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Zhao Y, Xiao A, diPierro CG, Carpenter JE, Abdel-Fattah R, Redpath GT, Lopes MB and Hussaini IM: An extensive invasive intracranial human glioblastoma xenograft model: Role of high level matrix metalloproteinase 9. Am J Pathol. 176:3032–3049. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu K, Pei H, Zhang Z, Dong S, Fu R, Wang W and Wang H: FoxO3a mediates glioma cell invasion by regulating MMP9 expression. Oncol Rep 36: 3044-3050, 2016.
APA
Xu, K., Pei, H., Zhang, Z., Dong, S., Fu, R., Wang, W., & Wang, H. (2016). FoxO3a mediates glioma cell invasion by regulating MMP9 expression. Oncology Reports, 36, 3044-3050. https://doi.org/10.3892/or.2016.5087
MLA
Xu, K., Pei, H., Zhang, Z., Dong, S., Fu, R., Wang, W., Wang, H."FoxO3a mediates glioma cell invasion by regulating MMP9 expression". Oncology Reports 36.5 (2016): 3044-3050.
Chicago
Xu, K., Pei, H., Zhang, Z., Dong, S., Fu, R., Wang, W., Wang, H."FoxO3a mediates glioma cell invasion by regulating MMP9 expression". Oncology Reports 36, no. 5 (2016): 3044-3050. https://doi.org/10.3892/or.2016.5087
Copy and paste a formatted citation
x
Spandidos Publications style
Xu K, Pei H, Zhang Z, Dong S, Fu R, Wang W and Wang H: FoxO3a mediates glioma cell invasion by regulating MMP9 expression. Oncol Rep 36: 3044-3050, 2016.
APA
Xu, K., Pei, H., Zhang, Z., Dong, S., Fu, R., Wang, W., & Wang, H. (2016). FoxO3a mediates glioma cell invasion by regulating MMP9 expression. Oncology Reports, 36, 3044-3050. https://doi.org/10.3892/or.2016.5087
MLA
Xu, K., Pei, H., Zhang, Z., Dong, S., Fu, R., Wang, W., Wang, H."FoxO3a mediates glioma cell invasion by regulating MMP9 expression". Oncology Reports 36.5 (2016): 3044-3050.
Chicago
Xu, K., Pei, H., Zhang, Z., Dong, S., Fu, R., Wang, W., Wang, H."FoxO3a mediates glioma cell invasion by regulating MMP9 expression". Oncology Reports 36, no. 5 (2016): 3044-3050. https://doi.org/10.3892/or.2016.5087
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