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Article

Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer

  • Authors:
    • Chao Huang
    • Hong Liu
    • Xiu-Li Gong
    • Liyun Wu
    • Bin Wen
  • View Affiliations / Copyright

    Affiliations: PI‑WEI Institute of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510000, P.R. China
  • Pages: 2705-2714
    |
    Published online on: September 19, 2016
       https://doi.org/10.3892/or.2016.5104
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Abstract

Tissue microenvironment functions as a pivotal mediator in colorectal carcinogenesis, and its alteration can cause some important cellular responses including epigenetic events. The present study examined histologically altered tissue structure, DNA methyltransferases (DNMTs) and their corresponding expression of target microRNAs (miRNA). Tissues resected by surgery were from primary colorectal carcinoma. These samples were from three locations: and were ≥10, 5 and ≤2 cm away from the proximal lesion of colon cancer, and marked as no. 1, no. 2 and no. 3, respectively. Histological alteration was assessed by H&E staining, expression of DNMT1, DNMT3A, and DNMT3B was detected by immunohistochemistry and western blotting, microarray chip was used to screen distinguishable miRNAs and miRNAs targeting DNMTs whose validation assay was performed by quantitative real-time polymerase chain reaction (qRT-PCR). Our results revealed that normal crypt structure was shown in no. 1, while many aberrant crypt foci appeared in no. 3. Significant upregulation of DNMT1, DNMT3A, and DNMT3B expression was found in para-carcinoma tissues, compared with the histopathologically unchanged tissues (P<0.05), furthermore, distinguishable expression profiling was observed of target miRNAs in tissues with different distance. Our results provide additional insights for future research of colorectal carcinogenesis by introducing the tissue microenvironment.
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View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Dawson MA and Kouzarides T: Cancer epigenetics: From mechanism to therapy. Cell. 150:12–27. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Migheli F and Migliore L: Epigenetics of colorectal cancer. Clin Genet. 81:312–318. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Feinberg AP and Tycko B: The history of cancer epigenetics. Nat Rev Cancer. 4:143–153. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Sahnane N, Magnoli F, Bernasconi B, Tibiletti MG, Romualdi C, Pedroni M, Ponz de Leon M, Magnani G, Reggiani-Bonetti L, Bertario L, et al: AIFEG: Aberrant DNA methylation profiles of inherited and sporadic colorectal cancer. Clin Epigenetics. 7:1312015. View Article : Google Scholar

6 

Baylin SB, Herman JG, Graff JR, Vertino PM and Issa JP: Alterations in DNA methylation: A fundamental aspect of neoplasia. Adv Cancer Res. 72:141–196. 1998. View Article : Google Scholar

7 

Robertson KD, Uzvolgyi E, Liang G, Talmadge C, Sumegi J, Gonzales FA and Jones PA: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 27:2291–2298. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Stefani G and Slack FJ: Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol. 9:219–230. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Hwang HW and Mendell JT: MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer. 94:776–780. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Rangel-Salazar R, Wickström-Lindholm M, Aguilar-Salinas CA, Alvarado-Caudillo Y, Døssing KB, Esteller M, Labourier E, Lund G, Nielsen FC, Rodríguez-Ríos D, et al: Human native lipoprotein-induced de novo DNA methylation is associated with repression of inflammatory genes in THP-1 macrophages. BMC Genomics. 12:5822011. View Article : Google Scholar : PubMed/NCBI

11 

Mori Y, Ishiguro H, Kuwabara Y, Kimura M, Mitsui A, Ogawa R, Katada T, Harata K, Tanaka T, Shiozaki M, et al: MicroRNA-21 induces cell proliferation and invasion in esophageal squamous cell carcinoma. Mol Med Rep. 2:235–239. 2009.PubMed/NCBI

12 

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, et al: MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65:7065–7070. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Song YX, Yue ZY, Wang ZN, Xu YY, Luo Y, Xu HM, Zhang X, Jiang L, Xing CZ and Zhang Y: MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation. Mol Cancer. 10:12011. View Article : Google Scholar : PubMed/NCBI

14 

Matsubara N: Epigenetic regulation and colorectal cancer. Dis Colon Rectum. 55:96–104. 2012. View Article : Google Scholar

15 

Wu WK, Law PT, Lee CW, Cho CH, Fan D, Wu K, Yu J and Sung JJ: MicroRNA in colorectal cancer: From benchtop to bedside. Carcinogenesis. 32:247–253. 2011. View Article : Google Scholar

16 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Egeblad M, Nakasone ES and Werb Z: Tumors as organs: Complex tissues that interface with the entire organism. Dev Cell. 18:884–901. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Weber CE and Kuo PC: The tumor microenvironment. Surg Oncol. 21:172–177. 2012. View Article : Google Scholar

19 

Paulsen JE, Namork E, Steffensen IL, Eide TJ and Alexander J: Identification and quantification of aberrant crypt foci in the colon of Min mice - a murine model of familial adenomatous polyposis. Scand J Gastroenterol. 35:534–539. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Serrano M, Hannon GJ and Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 366:704–707. 1993. View Article : Google Scholar : PubMed/NCBI

21 

Lin RJ, Lubpairee T, Liu KY, Anderson DW, Durham S and Poh CF: Cyclin D1 overexpression is associated with poor prognosis in oropharyngeal cancer. J Otolaryngol Head Neck Surg. 42:232013. View Article : Google Scholar : PubMed/NCBI

22 

Ren B, Li W, Yang Y and Wu S: The impact of cyclin D1 overexpression on the prognosis of bladder cancer: A meta-analysis. World J Surg Oncol. 12:552014. View Article : Google Scholar : PubMed/NCBI

23 

O'Brien CA, Pollett A, Gallinger S and Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 445:106–110. 2007. View Article : Google Scholar

24 

Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C and De Maria R: Identification and expansion of human colon-cancer-initiating cells. Nature. 445:111–115. 2007. View Article : Google Scholar

25 

Snásel J, Shoeman R, Horejsí M, Hrusková-Heidingsfeldová O, Sedlácek J, Ruml T and Pichová I: Cleavage of vimentin by different retroviral proteases. Arch Biochem Biophys. 377:241–245. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Hondo T, Kanaya T, Takakura I, Watanabe H, Takahashi Y, Nagasawa Y, Terada S, Ohwada S, Watanabe K, Kitazawa H, et al: Cytokeratin 18 is a specific marker of bovine intestinal M cell. Am J Physiol Gastrointest Liver Physiol. 300:G442–G453. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Singh S, Sadacharan S, Su S, Belldegrun A, Persad S and Singh G: Overexpression of vimentin: Role in the invasive phenotype in an androgen-independent model of prostate cancer. Cancer Res. 63:2306–2311. 2003.PubMed/NCBI

28 

Previati M, Manfrini M, Galasso M, Zerbinati C, Palatini J, Gasparini P and Volinia S: Next generation analysis of breast cancer genomes for precision medicine. Cancer Lett. 339:1–7. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Chen XY, He QY and Guo MZ: XAF1 is frequently methylated in human esophageal cancer. World J Gastroenterol. 18:2844–2849. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Cao XY, Ma HX, Shang YH, Jin MS, Kong F, Jia ZF, Cao DH, Wang YP, Suo J and Jiang J: DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer. World J Gastroenterol. 20:8201–8208. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Seidel C, Florean C, Schnekenburger M, Dicato M and Diederich M: Chromatin-modifying agents in anti-cancer therapy. Biochimie. 94:2264–2279. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Walton EL, Francastel C and Velasco G: Maintenance of DNA methylation: Dnmt3b joins the dance. Epigenetics. 6:1373–1377. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Van Emburgh BO and Robertson KD: Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants. Nucleic Acids Res. 39:4984–5002. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Ooi SK, O'Donnell AH and Bestor TH: Mammalian cytosine methylation at a glance. J Cell Sci. 122:2787–2791. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Schnekenburger M and Diederich M: Epigenetics Offer New Horizons for Colorectal Cancer Prevention. Curr Colorectal Cancer Rep. 8:66–81. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Florean C, Schnekenburger M, Grandjenette C, Dicato M and Diederich M: Epigenomics of leukemia: From mechanisms to therapeutic applications. Epigenomics. 3:581–609. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Kanai Y and Hirohashi S: Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state. Carcinogenesis. 28:2434–2442. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Karius T, Schnekenburger M, Ghelfi J, Walter J, Dicato M and Diederich M: Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines. Biochem Pharmacol. 81:1329–1342. 2011. View Article : Google Scholar : PubMed/NCBI

39 

van Engeland M, Derks S, Smits KM, Meijer GA and Herman JG: Colorectal cancer epigenetics: Complex simplicity. J Clin Oncol. 29:1382–1391. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Vaiopoulos AG, Athanasoula KC and Papavassiliou AG: Epigenetic modifications in colorectal cancer: Molecular insights and therapeutic challenges. Biochim Biophys Acta. 1842:971–980. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Yoneyama K, Ishibashi O, Kawase R, Kurose K and Takeshita T: miR-200a, miR-200b and miR-429 are onco-miRs that target the PTEN gene in endometrioid endometrial carcinoma. Anticancer Res. 35:1401–1410. 2015.PubMed/NCBI

42 

Roy S and Majumdar AP: Cancer stem cells in colorectal cancer: genetic and epigenetic changes. J Stem Cell Res Ther. (Suppl 7): pii: 10342.

43 

Tost J: DNA methylation: An introduction to the biology and the disease-associated changes of a promising biomarker. Mol Biotechnol. 44:71–81. 2010. View Article : Google Scholar

44 

Hammoud SS, Cairns BR and Jones DA: Epigenetic regulation of colon cancer and intestinal stem cells. Curr Opin Cell Biol. 25:177–183. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Choong MK and Tsafnat G: Genetic and epigenetic biomarkers of colorectal cancer. Clin Gastroenterol Hepatol. 10:9–15. 2012. View Article : Google Scholar

46 

Mima K, Nishihara R, Qian ZR, Cao Y, Sukawa Y, Nowak JA, Yang J, Dou R, Masugi Y, Song M, et al: Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. Gut. Aug 26–2015.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

47 

Tahara T, Yamamoto E, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, An B, et al: Fusobacterium in colonic flora and molecular features of colorectal carcinoma. Cancer Res. 74:1311–1318. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Ogino S, Lochhead P, Chan AT, Nishihara R, Cho E, Wolpin BM, Meyerhardt JA, Meissner A, Schernhammer ES, Fuchs CS, et al: Molecular pathological epidemiology of epigenetics: Emerging integrative science to analyze environment, host, and disease. Mod Pathol. 26:465–484. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Potter JD: Morphogens, morphostats, microarchitecture and malignancy. Nat Rev Cancer. 7:464–474. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Thompson EW, Newgreen DF and Tarin D: Carcinoma invasion and metastasis: A role for epithelial-mesenchymal transition? Cancer Res. 65:5991–5995; discussion 5995. 2005. View Article : Google Scholar : PubMed/NCBI

51 

González-Ramírez I, Soto-Reyes E, Sánchez-Pérez Y, Herrera LA and García-Cuellar C: Histones and long non-coding RNAs: The new insights of epigenetic deregulation involved in oral cancer. Oral Oncol. 50:691–695. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Robertson KD: DNA methylation and human disease. Nat Rev Genet. 6:597–610. 2005. View Article : Google Scholar : PubMed/NCBI

53 

Li J, Jin H and Wang X: Epigenetic biomarkers: potential applications in gastrointestinal cancers. ISRN Gastroenterology. 2014:4640152014. View Article : Google Scholar : PubMed/NCBI

54 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang C, Liu H, Gong X, Wu L and Wen B: Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer. Oncol Rep 36: 2705-2714, 2016.
APA
Huang, C., Liu, H., Gong, X., Wu, L., & Wen, B. (2016). Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer. Oncology Reports, 36, 2705-2714. https://doi.org/10.3892/or.2016.5104
MLA
Huang, C., Liu, H., Gong, X., Wu, L., Wen, B."Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer". Oncology Reports 36.5 (2016): 2705-2714.
Chicago
Huang, C., Liu, H., Gong, X., Wu, L., Wen, B."Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer". Oncology Reports 36, no. 5 (2016): 2705-2714. https://doi.org/10.3892/or.2016.5104
Copy and paste a formatted citation
x
Spandidos Publications style
Huang C, Liu H, Gong X, Wu L and Wen B: Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer. Oncol Rep 36: 2705-2714, 2016.
APA
Huang, C., Liu, H., Gong, X., Wu, L., & Wen, B. (2016). Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer. Oncology Reports, 36, 2705-2714. https://doi.org/10.3892/or.2016.5104
MLA
Huang, C., Liu, H., Gong, X., Wu, L., Wen, B."Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer". Oncology Reports 36.5 (2016): 2705-2714.
Chicago
Huang, C., Liu, H., Gong, X., Wu, L., Wen, B."Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer". Oncology Reports 36, no. 5 (2016): 2705-2714. https://doi.org/10.3892/or.2016.5104
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