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Article

MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma

  • Authors:
    • Yun Yang
    • Jin Zhang
    • Tian Xia
    • Gaiyun Li
    • Tao Tian
    • Mengchao Wang
    • Ruoyu Wang
    • Linghao Zhao
    • Yuan Yang
    • Ke Lan
    • Weiping Zhou
  • View Affiliations / Copyright

    Affiliations: The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, P.R. China, The Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, P.R. China
  • Pages: 2553-2562
    |
    Published online on: September 23, 2016
       https://doi.org/10.3892/or.2016.5129
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Abstract

Hypoxia drives cancer to become more aggressive, particularly angiogenesis, and the corresponding mechanisms still need to be further investigated. In hepatocellular carcinoma (HCC), the master hypoxia-induced microRNA (miRNA) miR-210 is upregulated in HCC and participates in HCC progression, but its roles in hypoxia-induced HCC angiogenesis are still unknown. Moreover, the correlation between miR-210 expression and HCC clinical progression also needs elucidation. In the present study, we found that miR-210 expression was progressively increased from normal liver and adjacent non-tumor tissues, to incipient and advanced tumor tissues. In HCC patients, high miR-210 expression was significantly correlated with poor prognosis, both tumor-free survival and overall survival. Moreover, miR-210 expression in HCC was significantly positively correlated with microvascular density. Both in vitro and in vivo studies determined that miR-210 promoted HCC angiogenesis, and the corresponding mechanism was identified to be the direct targeting and inhibition of fibroblast growth factor receptor-like 1 (FGFRL1) expression. Thus, we suggest a new prognosis predictor for HCC patients, and determined the roles of hypoxic miR-210 in HCC angiogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Zhang J, Xia T, Li G, Tian T, Wang M, Wang R, Zhao L, Yang Y, Lan K, Lan K, et al: MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma. Oncol Rep 36: 2553-2562, 2016.
APA
Yang, Y., Zhang, J., Xia, T., Li, G., Tian, T., Wang, M. ... Zhou, W. (2016). MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma. Oncology Reports, 36, 2553-2562. https://doi.org/10.3892/or.2016.5129
MLA
Yang, Y., Zhang, J., Xia, T., Li, G., Tian, T., Wang, M., Wang, R., Zhao, L., Yang, Y., Lan, K., Zhou, W."MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma". Oncology Reports 36.5 (2016): 2553-2562.
Chicago
Yang, Y., Zhang, J., Xia, T., Li, G., Tian, T., Wang, M., Wang, R., Zhao, L., Yang, Y., Lan, K., Zhou, W."MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma". Oncology Reports 36, no. 5 (2016): 2553-2562. https://doi.org/10.3892/or.2016.5129
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Zhang J, Xia T, Li G, Tian T, Wang M, Wang R, Zhao L, Yang Y, Lan K, Lan K, et al: MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma. Oncol Rep 36: 2553-2562, 2016.
APA
Yang, Y., Zhang, J., Xia, T., Li, G., Tian, T., Wang, M. ... Zhou, W. (2016). MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma. Oncology Reports, 36, 2553-2562. https://doi.org/10.3892/or.2016.5129
MLA
Yang, Y., Zhang, J., Xia, T., Li, G., Tian, T., Wang, M., Wang, R., Zhao, L., Yang, Y., Lan, K., Zhou, W."MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma". Oncology Reports 36.5 (2016): 2553-2562.
Chicago
Yang, Y., Zhang, J., Xia, T., Li, G., Tian, T., Wang, M., Wang, R., Zhao, L., Yang, Y., Lan, K., Zhou, W."MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma". Oncology Reports 36, no. 5 (2016): 2553-2562. https://doi.org/10.3892/or.2016.5129
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