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Article

MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2

  • Authors:
    • Le Qin
    • Yu Zhang
    • Jie Lin
    • Yangping Shentu
    • Xiaoxiao Xie
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Medical Function Center of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Medical Imaging, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
  • Pages: 3325-3332
    |
    Published online on: September 30, 2016
       https://doi.org/10.3892/or.2016.5139
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Abstract

MicroRNA-455 (miR-455) has been considered as a novel cancer-related miRNA and dysregulated expression frequently occurs in various human types of cancer. However, its clinical significance, its biological function and the underlying molecular signaling involved in hepatocellular carcinoma (HCC) remain to be elucidated. In the present study, we found that the expression level of miR-455 was significantly downregulated in both HCC tissues and cell lines. Low expression of miR-455 was significantly associated with poor prognostic features including multiple tumor nodes, high Edmondson‑Steiner grading, advanced tumor-node‑metastasis (TNM) stage and venous infiltration. In addition, our data revealed that miR-455 was a novel prognostic indicator for predicting the 5-year overall and disease-free survival of HCC patients. The gain- and loss-of-function studies revealed that miR-455 significantly suppressed migration and invasion of HCC cells in vitro. miR-455 was inversely correlated with runt-related transcription factor 2 (Runx2) expression in HCC samples. Moreover, we identified that miR-455 inversely regulated Runx2 expression in HCC cells. In this investigation, Runx2 was found to be a direct downstream target of miR-455. Evidently, alteration in Runx2 expression suppressed the effect of miR-455 on HCC cell migration and invasion. In conclusion, our data demonstrated that miR-455 promotes HCC growth by targeting Runx2 and can potentially be regarded as a novel prognostic indicator and valuable therapeutic strategy for HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Qin L, Zhang Y, Lin J, Shentu Y and Xie X: MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2. Oncol Rep 36: 3325-3332, 2016.
APA
Qin, L., Zhang, Y., Lin, J., Shentu, Y., & Xie, X. (2016). MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2. Oncology Reports, 36, 3325-3332. https://doi.org/10.3892/or.2016.5139
MLA
Qin, L., Zhang, Y., Lin, J., Shentu, Y., Xie, X."MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2". Oncology Reports 36.6 (2016): 3325-3332.
Chicago
Qin, L., Zhang, Y., Lin, J., Shentu, Y., Xie, X."MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2". Oncology Reports 36, no. 6 (2016): 3325-3332. https://doi.org/10.3892/or.2016.5139
Copy and paste a formatted citation
x
Spandidos Publications style
Qin L, Zhang Y, Lin J, Shentu Y and Xie X: MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2. Oncol Rep 36: 3325-3332, 2016.
APA
Qin, L., Zhang, Y., Lin, J., Shentu, Y., & Xie, X. (2016). MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2. Oncology Reports, 36, 3325-3332. https://doi.org/10.3892/or.2016.5139
MLA
Qin, L., Zhang, Y., Lin, J., Shentu, Y., Xie, X."MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2". Oncology Reports 36.6 (2016): 3325-3332.
Chicago
Qin, L., Zhang, Y., Lin, J., Shentu, Y., Xie, X."MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2". Oncology Reports 36, no. 6 (2016): 3325-3332. https://doi.org/10.3892/or.2016.5139
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