Pathogenic mechanisms of the oncoprotein CagA in H. pylori-induced gastric cancer (Review)

  • Authors:
    • Shuai-Yin Chen
    • Rong-Guang Zhang
    • Guang-Cai Duan
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  • Published online on: October 4, 2016     https://doi.org/10.3892/or.2016.5145
  • Pages: 3087-3094
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Abstract

Infection with Helicobacter pylori is the strongest risk factor for the development of chronic gastritis, gastric ulcer and gastric carcinoma. The majority of the H. pylori-infected population remains asymptomatic, and only 1% of individuals may progress to gastric cancer. The clinical outcomes caused by H. pylori infection are considered to be associated with bacterial virulence, genetic polymorphism of hosts as well as environmental factors. Most H. pylori strains possess a cytotoxin-associated gene (cag) pathogenicity island (cagPAI), encoding a 120-140 kDa CagA protein, which is the most important bacterial oncoprotein. CagA is translocated into host cells via T4SS system and affects the expression of signaling proteins in a phosphorylation-dependent and independent manner. Thus, this review summarizes the results of relevant studies, discusses the pathogenesis of CagA-mediated gastric cancer.
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December-2016
Volume 36 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Chen S, Zhang R and Duan G: Pathogenic mechanisms of the oncoprotein CagA in H. pylori-induced gastric cancer (Review). Oncol Rep 36: 3087-3094, 2016
APA
Chen, S., Zhang, R., & Duan, G. (2016). Pathogenic mechanisms of the oncoprotein CagA in H. pylori-induced gastric cancer (Review). Oncology Reports, 36, 3087-3094. https://doi.org/10.3892/or.2016.5145
MLA
Chen, S., Zhang, R., Duan, G."Pathogenic mechanisms of the oncoprotein CagA in H. pylori-induced gastric cancer (Review)". Oncology Reports 36.6 (2016): 3087-3094.
Chicago
Chen, S., Zhang, R., Duan, G."Pathogenic mechanisms of the oncoprotein CagA in H. pylori-induced gastric cancer (Review)". Oncology Reports 36, no. 6 (2016): 3087-3094. https://doi.org/10.3892/or.2016.5145