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Role of HOTAIR in the diagnosis and prognosis of acute leukemia

  • Authors:
    • Yuan-Yuan Zhang
    • Si-Han Huang
    • Hua-Rong Zhou
    • Cong‑Jie Chen
    • Li-Hong Tian
    • Jian-Zhen Shen
  • View Affiliations / Copyright

    Affiliations: Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3113-3122
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    Published online on: October 4, 2016
       https://doi.org/10.3892/or.2016.5147
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Abstract

HOX antisense intergenic RNA (HOTAIR), a long non-coding RNA, plays an important role in the development of many types of cancers. Its function in acute leukemia (AL), however, has not been examined. The present study investigated the role of HOTAIR and its downstream genes in AL, and determined whether it could act as a molecular marker for prediction of leukemia development and prognosis. Real-time quantitative PCR was used to examine the expression of each gene in the HOTAIR signaling pathway in AL patients. The relationship between expression of HOTAIR and downstream genes and AL prognosis was analyzed. Expression of HOTAIR in patients with acute monocytic leukemia (M5) was increased as compared to controls (P<0.05). Compared to patients with low HOTAIR expression, overall survival and event-free survival of patients with high HOTAIR expression was significantly reduced. In addition, the expression of downstream genes in the HOTAIR signaling pathway including EZH2, LSD1, DNMT3A and DNMT3B was significantly increased in AL patients, and showed a significant positive correlation with high expression of HOTAIR (P<0.05). In conclusion, HOTAIR was closely related with a poor prognosis in AL patients. It may be involved in the development of leukemia by mediating methylation of DNA and histones.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Huang S, Zhou H, Chen CJ, Tian L and Shen J: Role of HOTAIR in the diagnosis and prognosis of acute leukemia. Oncol Rep 36: 3113-3122, 2016.
APA
Zhang, Y., Huang, S., Zhou, H., Chen, C., Tian, L., & Shen, J. (2016). Role of HOTAIR in the diagnosis and prognosis of acute leukemia. Oncology Reports, 36, 3113-3122. https://doi.org/10.3892/or.2016.5147
MLA
Zhang, Y., Huang, S., Zhou, H., Chen, C., Tian, L., Shen, J."Role of HOTAIR in the diagnosis and prognosis of acute leukemia". Oncology Reports 36.6 (2016): 3113-3122.
Chicago
Zhang, Y., Huang, S., Zhou, H., Chen, C., Tian, L., Shen, J."Role of HOTAIR in the diagnosis and prognosis of acute leukemia". Oncology Reports 36, no. 6 (2016): 3113-3122. https://doi.org/10.3892/or.2016.5147
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Huang S, Zhou H, Chen CJ, Tian L and Shen J: Role of HOTAIR in the diagnosis and prognosis of acute leukemia. Oncol Rep 36: 3113-3122, 2016.
APA
Zhang, Y., Huang, S., Zhou, H., Chen, C., Tian, L., & Shen, J. (2016). Role of HOTAIR in the diagnosis and prognosis of acute leukemia. Oncology Reports, 36, 3113-3122. https://doi.org/10.3892/or.2016.5147
MLA
Zhang, Y., Huang, S., Zhou, H., Chen, C., Tian, L., Shen, J."Role of HOTAIR in the diagnosis and prognosis of acute leukemia". Oncology Reports 36.6 (2016): 3113-3122.
Chicago
Zhang, Y., Huang, S., Zhou, H., Chen, C., Tian, L., Shen, J."Role of HOTAIR in the diagnosis and prognosis of acute leukemia". Oncology Reports 36, no. 6 (2016): 3113-3122. https://doi.org/10.3892/or.2016.5147
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