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Article

CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners

Retraction in: /10.3892/or.2021.8163
  • Authors:
    • Zhijie Dai
    • Jun Wu
    • Fenghua Chen
    • Quan Cheng
    • Mingyu Zhang
    • Ying Wang
    • Yong Guo
    • Tao Song
  • View Affiliations / Copyright

    Affiliations: Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 3303-3310
    |
    Published online on: October 10, 2016
       https://doi.org/10.3892/or.2016.5155
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Abstract

CXCL5 and its receptor CXCR2 have been found to be involved in tumorigenesis and cancer progression. Recent studies have shown that CXCR2 is upregulated in glioma tissues, and associated with poor prognosis and recurrence. However, the role of CXCL5/CXCR2 signaling in mediating the malignant phenotypes of glioma cells, as well as the underlying mechanism, still remains unclear. In the present study, we found that CXCL5 was upregulated in glioma tissues compared to that noted in normal brain tissues. High CXCL5 levels were significantly associated with higher tumor grade, advanced clinical stage, and shorter survival time of glioma patients. In vitro studies indicated that the protein expression levels of CXCL5 and CXCR2 were markedly higher in human glioma cell lines (U87, U251, U373 and A172), when compared with those in normal human gliocyte HEB cells. Overexpression of CXLC5 significantly promoted the proliferation and migration of U87 cells, while knockdown of CXCL5 by small interfering RNA markedly inhibited U87 cell proliferation and migration. Moreover, both exogenous CXCL5 treatment and the conditioned medium of CXCL5-overexpressing HEB cells also enhanced the proliferation and migration of U87 cells. Molecular mechanism investigation revealed that CXLC5 activated the ERK, JNK, p38 MAPK signaling pathways, which play key roles in tumor growth and metastasis. According to these data, our study suggests that CXCL5 plays a promoting role in glioma in autocrine- and paracrine-dependent manners.
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Copy and paste a formatted citation
Spandidos Publications style
Dai Z, Wu J, Chen F, Cheng Q, Zhang M, Wang Y, Guo Y and Song T: CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners Retraction in /10.3892/or.2021.8163. Oncol Rep 36: 3303-3310, 2016.
APA
Dai, Z., Wu, J., Chen, F., Cheng, Q., Zhang, M., Wang, Y. ... Song, T. (2016). CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners Retraction in /10.3892/or.2021.8163. Oncology Reports, 36, 3303-3310. https://doi.org/10.3892/or.2016.5155
MLA
Dai, Z., Wu, J., Chen, F., Cheng, Q., Zhang, M., Wang, Y., Guo, Y., Song, T."CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners Retraction in /10.3892/or.2021.8163". Oncology Reports 36.6 (2016): 3303-3310.
Chicago
Dai, Z., Wu, J., Chen, F., Cheng, Q., Zhang, M., Wang, Y., Guo, Y., Song, T."CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners Retraction in /10.3892/or.2021.8163". Oncology Reports 36, no. 6 (2016): 3303-3310. https://doi.org/10.3892/or.2016.5155
Copy and paste a formatted citation
x
Spandidos Publications style
Dai Z, Wu J, Chen F, Cheng Q, Zhang M, Wang Y, Guo Y and Song T: CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners Retraction in /10.3892/or.2021.8163. Oncol Rep 36: 3303-3310, 2016.
APA
Dai, Z., Wu, J., Chen, F., Cheng, Q., Zhang, M., Wang, Y. ... Song, T. (2016). CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners Retraction in /10.3892/or.2021.8163. Oncology Reports, 36, 3303-3310. https://doi.org/10.3892/or.2016.5155
MLA
Dai, Z., Wu, J., Chen, F., Cheng, Q., Zhang, M., Wang, Y., Guo, Y., Song, T."CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners Retraction in /10.3892/or.2021.8163". Oncology Reports 36.6 (2016): 3303-3310.
Chicago
Dai, Z., Wu, J., Chen, F., Cheng, Q., Zhang, M., Wang, Y., Guo, Y., Song, T."CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners Retraction in /10.3892/or.2021.8163". Oncology Reports 36, no. 6 (2016): 3303-3310. https://doi.org/10.3892/or.2016.5155
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