c-Fos/ERK promotes the progression from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma

  • Authors:
    • Lei You
    • Xiaoxia Ren
    • Yongxing Du
    • Wenjing Zhao
    • Ming Cui
    • Ge Chen
    • Yupei Zhao
  • View Affiliations

  • Published online on: October 13, 2016     https://doi.org/10.3892/or.2016.5169
  • Pages: 3413-3420
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Abstract

Pathogenesis of pancreatic ductal adenocarcinoma (PDAC) is thought to develop through the progression of precursor lesions, known as pancreatic intraepithelial neoplasias (PanIN). In the present study, we showed that c-Fos promoted proliferation, cell cycle and migration in pancreatic cancer cells. Caerulein was used to accelerate the pathogenesis of Pdx-cre; KrasG12D mice. During PanIN formation and development of PDAC, the expression of ERK and c-Fos increased concomitantly. When ERK activity was inhibited by U0126, the expression of c-Fos also decreased. Inactivation of ERK/c-Fos suppressed pancreatic lesions concurrently through proliferation, inflammation and apoptosis. Our findings suggest that the ERK/c-Fos pathway is required for PDAC initiation and progression.
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December-2016
Volume 36 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
You L, Ren X, Du Y, Zhao W, Cui M, Chen G and Zhao Y: c-Fos/ERK promotes the progression from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma. Oncol Rep 36: 3413-3420, 2016
APA
You, L., Ren, X., Du, Y., Zhao, W., Cui, M., Chen, G., & Zhao, Y. (2016). c-Fos/ERK promotes the progression from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma. Oncology Reports, 36, 3413-3420. https://doi.org/10.3892/or.2016.5169
MLA
You, L., Ren, X., Du, Y., Zhao, W., Cui, M., Chen, G., Zhao, Y."c-Fos/ERK promotes the progression from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma". Oncology Reports 36.6 (2016): 3413-3420.
Chicago
You, L., Ren, X., Du, Y., Zhao, W., Cui, M., Chen, G., Zhao, Y."c-Fos/ERK promotes the progression from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma". Oncology Reports 36, no. 6 (2016): 3413-3420. https://doi.org/10.3892/or.2016.5169