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Article

Comparative proteomic analysis of melanosis coli with colon cancer

  • Authors:
    • Xin Zhou
    • Ping Wang
    • Ying-Jian Zhang
    • Jin-Jin Xu
    • La-Mei Zhang
    • Lin Zhu
    • Li-Ping Xu
    • Xiao-Min Liu
    • Huan-Huan Su
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China, Department of Public Health, Faculty of Medicine, Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China
  • Pages: 3700-3706
    |
    Published online on: October 17, 2016
       https://doi.org/10.3892/or.2016.5178
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Abstract

The present study aimed to investigate the proteomic difference between melanosis coli (MC) alone and melanosis coli with colon cancer (MCCC). Protein expression in patients with different diseases was analyzed using two-dimensional gel electrophoresis and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF/TOF-MS). A total of 14 protein differences with a confidence level of >95% were found. There were six differences between MC and normal tissues, in which two proteins exhibited upregulated expression levels and four proteins exhibited downregulated expression levels in MC. Furthermore, one protein was expressed only in MC (P<0.05). In addition, there were differences in the expression of eight proteins between MC and MCCC tissues, in which one protein had an upregulated expression in MC tissues and seven proteins had an upregulated expression in MCCC tissues. Furthermore, two proteins were only expressed in MCCC tissues (P<0.05). Eight proteins were identified using mass spectrometry and database search. In conclusion, comparative proteomics accurately displayed the expression differences in eight proteins between MC, MCCC and normal colon tissues.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Wang P, Zhang Y, Xu J, Zhang L, Zhu L, Xu L, Liu X and Su H: Comparative proteomic analysis of melanosis coli with colon cancer. Oncol Rep 36: 3700-3706, 2016.
APA
Zhou, X., Wang, P., Zhang, Y., Xu, J., Zhang, L., Zhu, L. ... Su, H. (2016). Comparative proteomic analysis of melanosis coli with colon cancer. Oncology Reports, 36, 3700-3706. https://doi.org/10.3892/or.2016.5178
MLA
Zhou, X., Wang, P., Zhang, Y., Xu, J., Zhang, L., Zhu, L., Xu, L., Liu, X., Su, H."Comparative proteomic analysis of melanosis coli with colon cancer". Oncology Reports 36.6 (2016): 3700-3706.
Chicago
Zhou, X., Wang, P., Zhang, Y., Xu, J., Zhang, L., Zhu, L., Xu, L., Liu, X., Su, H."Comparative proteomic analysis of melanosis coli with colon cancer". Oncology Reports 36, no. 6 (2016): 3700-3706. https://doi.org/10.3892/or.2016.5178
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Wang P, Zhang Y, Xu J, Zhang L, Zhu L, Xu L, Liu X and Su H: Comparative proteomic analysis of melanosis coli with colon cancer. Oncol Rep 36: 3700-3706, 2016.
APA
Zhou, X., Wang, P., Zhang, Y., Xu, J., Zhang, L., Zhu, L. ... Su, H. (2016). Comparative proteomic analysis of melanosis coli with colon cancer. Oncology Reports, 36, 3700-3706. https://doi.org/10.3892/or.2016.5178
MLA
Zhou, X., Wang, P., Zhang, Y., Xu, J., Zhang, L., Zhu, L., Xu, L., Liu, X., Su, H."Comparative proteomic analysis of melanosis coli with colon cancer". Oncology Reports 36.6 (2016): 3700-3706.
Chicago
Zhou, X., Wang, P., Zhang, Y., Xu, J., Zhang, L., Zhu, L., Xu, L., Liu, X., Su, H."Comparative proteomic analysis of melanosis coli with colon cancer". Oncology Reports 36, no. 6 (2016): 3700-3706. https://doi.org/10.3892/or.2016.5178
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