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Article

Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer

  • Authors:
    • Jiumao Lin
    • Jianyu Feng
    • Yiyi Jin
    • Zhaokun Yan
    • Zijun Lai
    • Jun Peng
  • View Affiliations / Copyright

    Affiliations: Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China
  • Pages: 3568-3576
    |
    Published online on: October 20, 2016
       https://doi.org/10.3892/or.2016.5186
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Abstract

Colorectal cancer (CRC) is one of the most common malignancies worldwide. The majority of patients are not suitable for surgery due to the presence of metastatic disease at the time of diagnosis, which has led to a high mortality rate for patients with CRC. Lymphangiogenesis, formation of new lymphatic vessels, plays an critical role in cancer progression particularly in cancer metastasis. Vascular endothelial growth factor-C (VEGF-C) has been previously demonstrated to play a pivotal role in cancer metastasis and therefore has become an attractive target for anticancer treatments. Pien Tze Huang (PZH) is a well-known traditional Chinese formula, which has exhibited significant therapeutic effects against CRC. However, the molecular mechanisms underlying its anticancer effects, particularly in regards to antimetastasis activity, still require further elucidation. In the present study, we evaluated the effects of PZH on cell migration and VEGF-C expression using various human CRC cell lines. Moreover, using a VEGF‑C-stimulated human lymphatic endothelial cell (HLEC) model, we demonstrated that PZH suppresses lymphangiogenesis by attenuating cell migration and tube formation. This indicates that PZH possesses significant antimetastatic activity. Moreover, suppression of lymphangiogenesis by PZH via the downregulation of VEGF-C may be a potential molecular mechanism by which PZH inhibits metastasis in CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Lin J, Feng J, Jin Y, Yan Z, Lai Z and Peng J: Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer. Oncol Rep 36: 3568-3576, 2016.
APA
Lin, J., Feng, J., Jin, Y., Yan, Z., Lai, Z., & Peng, J. (2016). Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer. Oncology Reports, 36, 3568-3576. https://doi.org/10.3892/or.2016.5186
MLA
Lin, J., Feng, J., Jin, Y., Yan, Z., Lai, Z., Peng, J."Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer". Oncology Reports 36.6 (2016): 3568-3576.
Chicago
Lin, J., Feng, J., Jin, Y., Yan, Z., Lai, Z., Peng, J."Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer". Oncology Reports 36, no. 6 (2016): 3568-3576. https://doi.org/10.3892/or.2016.5186
Copy and paste a formatted citation
x
Spandidos Publications style
Lin J, Feng J, Jin Y, Yan Z, Lai Z and Peng J: Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer. Oncol Rep 36: 3568-3576, 2016.
APA
Lin, J., Feng, J., Jin, Y., Yan, Z., Lai, Z., & Peng, J. (2016). Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer. Oncology Reports, 36, 3568-3576. https://doi.org/10.3892/or.2016.5186
MLA
Lin, J., Feng, J., Jin, Y., Yan, Z., Lai, Z., Peng, J."Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer". Oncology Reports 36.6 (2016): 3568-3576.
Chicago
Lin, J., Feng, J., Jin, Y., Yan, Z., Lai, Z., Peng, J."Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer". Oncology Reports 36, no. 6 (2016): 3568-3576. https://doi.org/10.3892/or.2016.5186
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