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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Article

TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways

  • Authors:
    • Zhenhua Zhang
    • Li Liu
    • Chunliang Liu
    • Shousong Cao
    • Yizhun Zhu
    • Qibing Mei
  • View Affiliations / Copyright

    Affiliations: State Institute of Pharmaceutical Industry, Shanghai 201203, P.R. China, School of Medicine, Soochow University, Suzhou, Jiangsu 215123, P.R. China, School of Pharmacy, Fudan University, Shanghai 201203, P.R. China
  • Pages: 3311-3316
    |
    Published online on: October 21, 2016
       https://doi.org/10.3892/or.2016.5192
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Abstract

Breast cancer is the second leading cause of cancer‑related deaths in female patients, and the main reasons are late diagnosis, limited therapeutic options and metastasis. Therefore, development of molecular therapeutic targets for breast cancer to suppress tumorigenesis, growth and metastasis may improve the therapeutic options and be of great benefit to patients. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is a novel molecule for maintaining immune homeostasis and is involved in cancer development. Previous studies have shown that TIPE2 plays a suppressive role in the development of several types of human cancers. However, its role in breast cancer is still not clear. In the present study, we detected TIPE2 expression in human breast cancer and adjacent normal tissues. The expression of TIPE2 was reduced in breast cancer tissues compared to the level in adjacent normal tissues. We then established a breast cancer cell line stably expressing TIPE2 to investigate the role of TIPE2 in breast cancer carcinogenesis. Our results showed that overexpression of TIPE2 significantly inhibited the proliferation of MDA-MB‑231 cells as detected by Cell Counting Kit-8 assay and suppressed the migration and invasion of breast cancer cells as detected by Transwell migration and invasion assays in vitro. TIPE2 also promoted cell apoptosis as detected by flow cytometry analysis. Moreover, TIPE2 inhibited the tumorigenesis of breast cancer in vivo. Mechanistically, TIPE2 inhibited the phosphorylation of AKT and p38 as detected by western blot analysis. Taken together, TIPE2 suppressed breast cancer tumorigenesis, growth and metastasis possibly via regulation of the AKT and p38 signaling pathways. The results indicate that TIPE2 may be a potential therapeutic target for breast cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Liu L, Liu C, Cao S, Zhu Y and Mei Q: TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways. Oncol Rep 36: 3311-3316, 2016.
APA
Zhang, Z., Liu, L., Liu, C., Cao, S., Zhu, Y., & Mei, Q. (2016). TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways. Oncology Reports, 36, 3311-3316. https://doi.org/10.3892/or.2016.5192
MLA
Zhang, Z., Liu, L., Liu, C., Cao, S., Zhu, Y., Mei, Q."TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways". Oncology Reports 36.6 (2016): 3311-3316.
Chicago
Zhang, Z., Liu, L., Liu, C., Cao, S., Zhu, Y., Mei, Q."TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways". Oncology Reports 36, no. 6 (2016): 3311-3316. https://doi.org/10.3892/or.2016.5192
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Liu L, Liu C, Cao S, Zhu Y and Mei Q: TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways. Oncol Rep 36: 3311-3316, 2016.
APA
Zhang, Z., Liu, L., Liu, C., Cao, S., Zhu, Y., & Mei, Q. (2016). TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways. Oncology Reports, 36, 3311-3316. https://doi.org/10.3892/or.2016.5192
MLA
Zhang, Z., Liu, L., Liu, C., Cao, S., Zhu, Y., Mei, Q."TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways". Oncology Reports 36.6 (2016): 3311-3316.
Chicago
Zhang, Z., Liu, L., Liu, C., Cao, S., Zhu, Y., Mei, Q."TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways". Oncology Reports 36, no. 6 (2016): 3311-3316. https://doi.org/10.3892/or.2016.5192
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