Myofibroblast distribution is associated with invasive growth types of colorectal cancer

Takatsuna,Masafumi; Morohashi,Satoko; Yoshizawa,Tadashi; Hirai,Hideaki; Haga,Toshihiro; Ota,Rie; Saito,Kensuke; Wu,Yunyan; Seino,Hiroko; Aoyagi,Yutaka; Terai,Shuji; Kijima,Hiroshi

doi:10.3892/or.2016.5202

Myofibroblast distribution is associated with invasive growth types of colorectal cancer

Authors:
- Masafumi Takatsuna
- Satoko Morohashi
- Tadashi Yoshizawa
- Hideaki Hirai
- Toshihiro Haga
- Rie Ota
- Kensuke Saito
- Yunyan Wu
- Hiroko Seino
- Yutaka Aoyagi
- Shuji Terai
- Hiroshi Kijima
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Affiliations: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan, Department of Gastroenterology, Niigata Medical Center, Niigata Prefectural Federation of Agricultural Cooperatives for Health and Welfare, Nishi-ku, Niigata 950-2022, Japan, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Chuo-ku, Niigata 951-8510, Japan
Published online on: October 25, 2016 https://doi.org/10.3892/or.2016.5202
Pages: 3154-3160
Copyright: © Takatsuna et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Both the invasive growth types of colorectal cancer (CRC) and the number of myofibroblasts have been associated with histopathological factors such as lymph node and liver metastasis, and local recurrence. However, there are few studies, that have assessed the association between invasive growth type and myofibroblast distribution in CRC. We aimed to evaluate the relationship between the clinicopathological factors of CRC and two invasive growth types, the expanding and infiltrating types. We categorized 150 cases of pT3 CRC into the expanding and infiltrating types and measured the myofibroblast density of three histological layers: the submucosa (SM), the muscularis propria (MP) and the subserosa (SS). We compared these two invasive growth types and analyzed the relationship between clinicopathological factors and myofibroblast density. Myofibroblast density was significantly higher in the infiltrating type than that in the expanding type (P<0.05). In the lymph node metastasis-positive group of the infiltrating type, myofibroblast density in MP was significantly higher than that in the lymph node metastasis-negative group (P<0.001). In the infiltrating type, the group with the higher level of lymphatic invasion had a significantly higher density of myofibroblasts in the MP than the group with the lower level of lymphatic invasion (P<0.01). These results suggest that myofibroblasts participate more in the infiltrating type compared with the expanding type of CRC. It would appear that myofibroblasts present in the MP play an important role in the malignant potential of the infiltrating type compared to the expanding type.

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