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Article

Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells

  • Authors:
    • Xiaoning Li
    • Yongwei Kang
    • Bingxuan Jiao
    • Meihui Xia
    • Yao Wu
    • Liankun Sun
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, Basic Medical College, Jilin University, Changchun, Jilin 130021, P.R. China, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Obstetrics and Gynecology, The First Hospital, Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 3353-3362
    |
    Published online on: October 27, 2016
       https://doi.org/10.3892/or.2016.5209
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Abstract

The endoplasmic reticulum (ER) is a membranous network within cells that is important for several cellular functions including translation and folding of secretory and membrane proteins, lipid biogenesis and sequestration of Ca2+. Disruption of ER structure might affect the normal physiology of the cells. In yeast, expansion of the ER is observed under unfolded protein response (UPR) and subsequently induces autophagy initiated from the ER. In this study, we demonstrated a drastic and specific ER membrane reorganization (EMR), characterized by the clustering of the ER membrane into large and compact aggregates and occurring independent of UPR in HeLa cells treated with S1 combined with ABT-737. Subsequently, combined with S1 and ABT-737 triggered autophagy. Herein, we report a key step for removal of damaged and superfluous cellular constituents, by a mechanistic link between ER aggregation and autophagic activation. Our study is the first time to show that autophagy may be a way to remove the ER membrane reorganization induced by Bcl-2 inhibitors ABT-737 and S1 and it may help us to analyze autophagy in certain diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Kang Y, Jiao B, Xia M, Wu Y and Sun L: Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells. Oncol Rep 36: 3353-3362, 2016.
APA
Li, X., Kang, Y., Jiao, B., Xia, M., Wu, Y., & Sun, L. (2016). Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells. Oncology Reports, 36, 3353-3362. https://doi.org/10.3892/or.2016.5209
MLA
Li, X., Kang, Y., Jiao, B., Xia, M., Wu, Y., Sun, L."Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells". Oncology Reports 36.6 (2016): 3353-3362.
Chicago
Li, X., Kang, Y., Jiao, B., Xia, M., Wu, Y., Sun, L."Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells". Oncology Reports 36, no. 6 (2016): 3353-3362. https://doi.org/10.3892/or.2016.5209
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Kang Y, Jiao B, Xia M, Wu Y and Sun L: Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells. Oncol Rep 36: 3353-3362, 2016.
APA
Li, X., Kang, Y., Jiao, B., Xia, M., Wu, Y., & Sun, L. (2016). Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells. Oncology Reports, 36, 3353-3362. https://doi.org/10.3892/or.2016.5209
MLA
Li, X., Kang, Y., Jiao, B., Xia, M., Wu, Y., Sun, L."Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells". Oncology Reports 36.6 (2016): 3353-3362.
Chicago
Li, X., Kang, Y., Jiao, B., Xia, M., Wu, Y., Sun, L."Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells". Oncology Reports 36, no. 6 (2016): 3353-3362. https://doi.org/10.3892/or.2016.5209
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