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Article

Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism

  • Authors:
    • Zhifan Yang
    • Xiucheng Li
    • Weiqi Han
    • Xuanyuan Lu
    • Songtao Jin
    • Wanlei Yang
    • Jianlei Li
    • Wei He
    • Yu Qian
  • View Affiliations / Copyright

    Affiliations: The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China, Department of Orthopaedics, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang 312000, P.R. China
  • Pages: 435-441
    |
    Published online on: November 7, 2016
       https://doi.org/10.3892/or.2016.5224
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Abstract

Osteosarcoma is the most common malignant bone tumor that frequently affects adolescents. Osteosarcoma cells tend to proliferate and invade other tissues such as those of the lungs. Currently, neoadjuvant chemotherapy is the primary strategy to prevent tumor progression. However, its adverse effects result in poor long-term outcomes. Previous research has shown that galangin exhibits antitumor properties on several types of cancer cells; however its effect on osteosarcoma cells is yet unknown. The aims of this study were to evaluate the effects of galangin on the proliferation, apoptosis, migration, and invasion of osteosarcoma cells and to explore the underlying mechanisms. We found that the proliferation of MG63 and U20S osteosarcoma cells decreased significantly, while the apoptosis of MG63 cells accelerated significantly after exposure to galangin. In addition, the migration and invasion of MG63 cells were significantly inhibited by galangin. Moreover, phosphoinositide 3-kinase (PI3K) and Aktp-Thr308 expression levels were found to be significantly lower in galangin-treated MG63 cells than in the control cells, and the protein expression levels of their downstream regulators cyclin D1 and matrix metalloproteinase 2/9 were also downregulated in galangin-treated groups, while those of p27Kip1, caspase-3, and caspase-8 were upregulated. These findings suggest that galangin suppresses osteosarcoma cells by inhibiting their proliferation and invasion and accelerating their apoptosis, and the mechanism may be associated with the inhibition of PI3K and its downstream signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Z, Li X, Han W, Lu X, Jin S, Yang W, Li J, He W and Qian Y: Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism. Oncol Rep 37: 435-441, 2017.
APA
Yang, Z., Li, X., Han, W., Lu, X., Jin, S., Yang, W. ... Qian, Y. (2017). Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism. Oncology Reports, 37, 435-441. https://doi.org/10.3892/or.2016.5224
MLA
Yang, Z., Li, X., Han, W., Lu, X., Jin, S., Yang, W., Li, J., He, W., Qian, Y."Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism". Oncology Reports 37.1 (2017): 435-441.
Chicago
Yang, Z., Li, X., Han, W., Lu, X., Jin, S., Yang, W., Li, J., He, W., Qian, Y."Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism". Oncology Reports 37, no. 1 (2017): 435-441. https://doi.org/10.3892/or.2016.5224
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Z, Li X, Han W, Lu X, Jin S, Yang W, Li J, He W and Qian Y: Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism. Oncol Rep 37: 435-441, 2017.
APA
Yang, Z., Li, X., Han, W., Lu, X., Jin, S., Yang, W. ... Qian, Y. (2017). Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism. Oncology Reports, 37, 435-441. https://doi.org/10.3892/or.2016.5224
MLA
Yang, Z., Li, X., Han, W., Lu, X., Jin, S., Yang, W., Li, J., He, W., Qian, Y."Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism". Oncology Reports 37.1 (2017): 435-441.
Chicago
Yang, Z., Li, X., Han, W., Lu, X., Jin, S., Yang, W., Li, J., He, W., Qian, Y."Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism". Oncology Reports 37, no. 1 (2017): 435-441. https://doi.org/10.3892/or.2016.5224
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