Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
January-2017 Volume 37 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2017 Volume 37 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Inhibiting β-catenin expression promotes efficiency of radioiodine treatment in aggressive follicular thyroid cancer cells probably through mediating NIS localization

  • Authors:
    • Ling Lan
    • Spyros Basourakos
    • Dai Cui
    • Xuemei Zuo
    • Wei Deng
    • Lili Huo
    • Linghai Chen
    • Guoying Zhang
    • Lili Deng
    • Bingyin Shi
    • Yong Luo
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Beijing Jishuitan Hospital, Beijing 100035, P.R. China, Department of Genitourinary, Cancer Medicine, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA, Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Endocrinology, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 426-434
    |
    Published online on: November 7, 2016
       https://doi.org/10.3892/or.2016.5228
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study investigated whether the efficacy of radioiodine therapy towards aggressive thyroid cancer cells was affected by β-catenin activity and associated with sodium/iodine symporter (NIS) localization. Human thyroid cancer cell line follicular thyroid carcinoma (FTC) 133 was endowed with aggressiveness by HIF-1α or β-catenin overexpression. The protein amount and subcellular localization of NIS, and the radioiodine uptake capacity were detected in the cells, as well as in cells subsequently undergoing β-catenin knockdown. Xenograft experiments were conducted to compare the tumor growth ability and responsiveness to radioactive treatment among HIF-1α and β-catenin overexpressing FTC cells, respectively with or without β-catenin knockdown. β-catenin increased upon HIF-1α overexpression, but not vice versa. This signal axis would prompt metastatic propensity in FTC cells, and translocate NIS from cytomembrane to cytoplasm. Consistently the radioiodine uptake capacity in the cells decreased obviously. Knockdown of β-catenin reversed all these changes. Furthermore, the xenograft experiments showed that radioiodine treatment could thoroughly suppress tumor growth ability of aggressive FTC cells only if the HIF-1α-induced β-catenin activation was disrupted by β-catenin knockdown. β-catenin nuclear translocation in tumor cells was accompanied by abnormal subcellular localization of NIS. Moreover, we found that only after inhibiting β-catenin expression, can the radioiodine treatment promote apoptosis other than repress proliferation and survival in xenograft tumor cells. In conclusion, aggressive FTC cells overexpressing HIF-1α will be fully cracked down by radioiodine therapy once β-catenin expression is inhibited, and regulated localization of NIS may account for underlying mechanisms.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Giannoula E, Iakovou I and Chatzipavlidou V: Risk factors and the progression of thyroid malignancies. Hell J Nucl Med. 18:275–284. 2015.(In Greek). PubMed/NCBI

2 

Mohamed AF, González JM and Fairchild A: Patient benefit-risk tradeoffs for radioactive iodine-refractory differentiated thyroid cancer treatments. J Thyroid Res. 2015:4382352015. View Article : Google Scholar : PubMed/NCBI

3 

Ferrari SM, Fallahi P, Politti U, Materazzi G, Baldini E, Ulisse S, Miccoli P and Antonelli A: Molecular targeted therapies of aggressive thyroid cancer. Front Endocrinol (Lausanne). 6:1762015.PubMed/NCBI

4 

Luo Y, He DL, Ning L, Shen SL, Li L, Li X, Zhau HE and Chung LW: Over-expression of hypoxia-inducible factor-1alpha increases the invasive potency of LNCaP cells in vitro. BJU Int. 98:1315–1319. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Steinert HC and Aberle S: CME: Radioactive iodine therapy in thyroid cancer. Praxis (Bern 1994). 104:1235–1243; quiz 1244–1235. 2015.[(In German)]. View Article : Google Scholar : PubMed/NCBI

6 

Dai G, Levy O and Carrasco N: Cloning and characterization of the thyroid iodide transporter. Nature. 379:458–460. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Smanik PA, Liu Q, Furminger TL, Ryu K, Xing S, Mazzaferri EL and Jhiang SM: Cloning of the human sodium lodide symporter. Biochem Biophys Res Commun. 226:339–345. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Matsuno A, Murakami M, Hoya K, Yamada SM, Miyamoto S, Yamada S, Son JH, Nishido H, Ide F, Nagashima H, et al: Clinicopathological and molecular histochemical review of skull base metastasis from differentiated thyroid carcinoma. Acta Histochem Cytochem. 46:129–136. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Bauer AJ: Thyroid nodules and differentiated thyroid cancer. Endocr Dev. 26:183–201. 2014.PubMed/NCBI

10 

Dadu R and Cabanillas ME: Optimizing therapy for radioactive iodine-refractory differentiated thyroid cancer: Current state of the art and future directions. Minerva Endocrinol. 37:335–356. 2012.PubMed/NCBI

11 

Rahmani N, Hashemi S Abbas, Fazli M and Raisian M: Clinical management and outcomes of papillary, follicular and medullary thyroid cancer surgery. Med Glas (Zenica). 10:164–167. 2013.PubMed/NCBI

12 

Phay JE and Ringel MD: Metastatic mechanisms in follicular cell-derived thyroid cancer. Endocr Relat Cancer. 20:R307–R319. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Dohán O, Baloch Z, Bánrévi Z, Livolsi V and Carrasco N: Rapid communication: Predominant intracellular overexpression of the Na+/I− symporter (NIS) in a large sampling of thyroid cancer cases. J Clin Endocrinol Metab. 86:2697–2700. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Saito T, Endo T, Kawaguchi A, Ikeda M, Katoh R, Kawaoi A, Muramatsu A and Onaya T: Increased expression of the sodium/iodide symporter in papillary thyroid carcinomas. J Clin Invest. 101:1296–1300. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Wapnir IL, van de Rijn M, Nowels K, Amenta PS, Walton K, Montgomery K, Greco RS, Dohán O and Carrasco N: Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections. J Clin Endocrinol Metab. 88:1880–1888. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Venkataraman GM, Yatin M, Marcinek R and Ain KB: Restoration of iodide uptake in dedifferentiated thyroid carcinoma: Relationship to human Na+/I-symporter gene methylation status. J Clin Endocrinol Metab. 84:2449–2457. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Arturi F, Russo D, Schlumberger M, du Villard JA, Caillou B, Vigneri P, Wicker R, Chiefari E, Suarez HG and Filetti S: Iodide symporter gene expression in human thyroid tumors. J Clin Endocrinol Metab. 83:2493–2496. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Dohán O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS and Carrasco N: The sodium/iodide Symporter (NIS): Characterization, regulation, and medical significance. Endocr Rev. 24:48–77. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Arturi F, Russo D, Giuffrida D, Schlumberger M and Filetti S: Sodium-iodide symporter (NIS) gene expression in lymph-node metastases of papillary thyroid carcinomas. Eur J Endocrinol. 143:623–627. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Boelaert K and Franklyn JA: Sodium iodide symporter: A novel strategy to target breast, prostate, and other cancers? Lancet. 361:796–797. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Xing M: Molecular pathogenesis and mechanisms of thyroid cancer. Nat Rev Cancer. 13:184–199. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Zhang Z, Liu D, Murugan AK, Liu Z and Xing M: Histone deacetylation of NIS promoter underlies BRAF V600E-promoted NIS silencing in thyroid cancer. Endocr Relat Cancer. 21:161–173. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Guo H, Xing Y, Liu Y, Luo Y, Deng F, Yang T, Yang K and Li Y: Wnt/β-catenin signaling pathway activates melanocyte stem cells in vitro and in vivo. J Dermatol Sci. 83:45–51. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Sastre-Perona A and Santisteban P: Wnt-independent role of β-catenin in thyroid cell proliferation and differentiation. Mol Endocrinol. 28:681–695. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Lan L, Deng W, Chen HL, Huo LL, Deng LL, Zhang GY and Luo Y: All-trans retinoic acid improves iodine uptake of thyroid cancer cells via repressing transcriptional activity of β-catenin. Zhonghua Yi Xue Za Zhi. 96:553–558. 2016.(In Chinese). PubMed/NCBI

26 

Rossi ED, Straccia P, Palumbo M, Stigliano E, Revelli L, Lombardi CP, Santeusanio G, Pontecorvi A and Fadda G: Diagnostic and prognostic role of HBME-1, galectin-3, and β-catenin in poorly differentiated and anaplastic thyroid carcinomas. Appl Immunohistochem Mol Morphol. 21:237–241. 2013.PubMed/NCBI

27 

Lan L, Luo Y, Cui D, Shi BY, Deng W, Huo LL, Chen HL, Zhang GY and Deng LL: Epithelial-mesenchymal transition induces cancer stem cell generation in human thyroid cancer cells in vitro. Zhonghua Yi Xue Za Zhi. 93:1261–1265. 2013.(In Chinese). PubMed/NCBI

28 

Pagni F, Manzoni M, Buscone S and Leone BE: β-catenin as a morpho-immunohistochemical marker for the diagnosis of papillary thyroid carcinoma. Arch Pathol Lab Med. 139:572–574. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Lan L, Deng W, Chen H, Huo L, Deng L, Zhang G and Luo Y: Nuclear translocation of β-catenin represses membrane localization of NIS in human thyroid cancer cells. Zhonghua Yi Xue Za Zhi. 96:891–896. 2016.(In Chinese). PubMed/NCBI

30 

Jin S, Borkhuu O, Bao W and Yang YT: Signaling pathways in thyroid cancer and their therapeutic implications. J Clin Med Res. 8:284–296. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Höckel M and Vaupel P: Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst. 93:266–276. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Zhang Q, Bai X, Chen W, Ma T, Hu Q, Liang C, Xie S, Chen C, Hu L, Xu S, et al: Wnt/β-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling. Carcinogenesis. 34:962–973. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Burrows N, Babur M, Resch J, Williams KJ and Brabant G: Hypoxia-inducible factor in thyroid carcinoma. J Thyroid Res. 2011:7629052011. View Article : Google Scholar : PubMed/NCBI

34 

Burrows N, Resch J, Cowen RL, von Wasielewski R, Hoang-Vu C, West CM, Williams KJ and Brabant G: Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas. Endocr Relat Cancer. 17:61–72. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Masoud GN and Li W: HIF-1α pathway: Role, regulation and intervention for cancer therapy. Acta Pharm Sin B. 5:378–389. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Goretzki PE, Frilling A, Simon D and Roeher HD: Growth regulation of normal thyroids and thyroid tumors in man. Recent Results Cancer Res. 118:48–63. 1990. View Article : Google Scholar : PubMed/NCBI

37 

Zhao JH, Luo Y, Jiang YG, He DL and Wu CT: Knockdown of β-catenin through shRNA cause a reversal of EMT and metastatic phenotypes induced by HIF-1α. Cancer Invest. 29:377–382. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Kraiem Z, Sadeh O and Yosef M: Iodide uptake and organification, tri-iodothyronine secretion, cyclic AMP accumulation and cell proliferation in an optimized system of human thyroid follicles cultured in collagen gel suspended in serum-free medium. J Endocrinol. 131:499–506. 1991. View Article : Google Scholar : PubMed/NCBI

39 

Lin H, Jiang X, Zhu H, Jiang W, Dong X, Qiao H, Sun X and Jiang H: 2ME2 inhibits the activated hypoxia-inducible pathways by cabozantinib and enhances its efficacy against medullary thyroid carcinoma. Tumour Biol. 37:381–391. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Zhang R, Wang H, Zhao J, Yao J, Shang H, Zhu H, Liao L and Dong J: Association between sodium iodide symporter and differentiated thyroid cancer: A meta-analysis of 9 studies. Int J Clin Exp Med. 8:17986–17994. 2015.PubMed/NCBI

41 

Riedel C, Levy O and Carrasco N: Post-transcriptional regulation of the sodium/iodide symporter by thyrotropin. J Biol Chem. 276:21458–21463. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lan L, Basourakos S, Cui D, Zuo X, Deng W, Huo L, Chen L, Zhang G, Deng L, Shi B, Shi B, et al: Inhibiting β-catenin expression promotes efficiency of radioiodine treatment in aggressive follicular thyroid cancer cells probably through mediating NIS localization. Oncol Rep 37: 426-434, 2017.
APA
Lan, L., Basourakos, S., Cui, D., Zuo, X., Deng, W., Huo, L. ... Luo, Y. (2017). Inhibiting β-catenin expression promotes efficiency of radioiodine treatment in aggressive follicular thyroid cancer cells probably through mediating NIS localization. Oncology Reports, 37, 426-434. https://doi.org/10.3892/or.2016.5228
MLA
Lan, L., Basourakos, S., Cui, D., Zuo, X., Deng, W., Huo, L., Chen, L., Zhang, G., Deng, L., Shi, B., Luo, Y."Inhibiting β-catenin expression promotes efficiency of radioiodine treatment in aggressive follicular thyroid cancer cells probably through mediating NIS localization". Oncology Reports 37.1 (2017): 426-434.
Chicago
Lan, L., Basourakos, S., Cui, D., Zuo, X., Deng, W., Huo, L., Chen, L., Zhang, G., Deng, L., Shi, B., Luo, Y."Inhibiting β-catenin expression promotes efficiency of radioiodine treatment in aggressive follicular thyroid cancer cells probably through mediating NIS localization". Oncology Reports 37, no. 1 (2017): 426-434. https://doi.org/10.3892/or.2016.5228
Copy and paste a formatted citation
x
Spandidos Publications style
Lan L, Basourakos S, Cui D, Zuo X, Deng W, Huo L, Chen L, Zhang G, Deng L, Shi B, Shi B, et al: Inhibiting β-catenin expression promotes efficiency of radioiodine treatment in aggressive follicular thyroid cancer cells probably through mediating NIS localization. Oncol Rep 37: 426-434, 2017.
APA
Lan, L., Basourakos, S., Cui, D., Zuo, X., Deng, W., Huo, L. ... Luo, Y. (2017). Inhibiting β-catenin expression promotes efficiency of radioiodine treatment in aggressive follicular thyroid cancer cells probably through mediating NIS localization. Oncology Reports, 37, 426-434. https://doi.org/10.3892/or.2016.5228
MLA
Lan, L., Basourakos, S., Cui, D., Zuo, X., Deng, W., Huo, L., Chen, L., Zhang, G., Deng, L., Shi, B., Luo, Y."Inhibiting β-catenin expression promotes efficiency of radioiodine treatment in aggressive follicular thyroid cancer cells probably through mediating NIS localization". Oncology Reports 37.1 (2017): 426-434.
Chicago
Lan, L., Basourakos, S., Cui, D., Zuo, X., Deng, W., Huo, L., Chen, L., Zhang, G., Deng, L., Shi, B., Luo, Y."Inhibiting β-catenin expression promotes efficiency of radioiodine treatment in aggressive follicular thyroid cancer cells probably through mediating NIS localization". Oncology Reports 37, no. 1 (2017): 426-434. https://doi.org/10.3892/or.2016.5228
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team