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Article

Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma

  • Authors:
    • Xinhua Zhu
    • Yu Ouyang
    • Fei Zhong
    • Qiru Wang
    • Linlin Ding
    • Peipei Zhang
    • Lingling Chen
    • Hong Liu
    • Song He
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Affiliated Cancer Hospital of Nantong University, Nantong, Jiangsu 226361, P.R. China, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Hematology, Affiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu 22600, P.R. China
  • Pages: 622-630
    |
    Published online on: November 8, 2016
       https://doi.org/10.3892/or.2016.5233
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Abstract

Casein kinase 2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is involved in regulating many processes such as cell proliferation, differentiation and apoptosis. CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma. In the present study, we found that CKIP-1 was reversely associated with the proliferation of non-Hodgkin's lymphoma (NHL) and cell adhesion mediated drug resistance (CAM-DR). We demonstrated that knockdown of CKIP-1 promoted the proliferation of NHL cells through interacting with Akt and suppressing Akt phosphorylation. In addition, adhesion of lymphoma cells to fibronectin or stroma cells (HS-5 cells) decreased CKIP-1 expression, which led to the upregulation of Akt phosphorylation. Importantly, we showed that the phosphorylation of Akt was correlated with CAM-DR phenotype in NHL cells. Taken together, the present study shed new light on the molecular mechanism of CAM-DR in NHL and targeting CKIP-1 may be a novel therapeutic target for NHL.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu X, Ouyang Y, Zhong F, Wang Q, Ding L, Zhang P, Chen L, Liu H and He S: Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma. Oncol Rep 37: 622-630, 2017.
APA
Zhu, X., Ouyang, Y., Zhong, F., Wang, Q., Ding, L., Zhang, P. ... He, S. (2017). Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma. Oncology Reports, 37, 622-630. https://doi.org/10.3892/or.2016.5233
MLA
Zhu, X., Ouyang, Y., Zhong, F., Wang, Q., Ding, L., Zhang, P., Chen, L., Liu, H., He, S."Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma". Oncology Reports 37.1 (2017): 622-630.
Chicago
Zhu, X., Ouyang, Y., Zhong, F., Wang, Q., Ding, L., Zhang, P., Chen, L., Liu, H., He, S."Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma". Oncology Reports 37, no. 1 (2017): 622-630. https://doi.org/10.3892/or.2016.5233
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu X, Ouyang Y, Zhong F, Wang Q, Ding L, Zhang P, Chen L, Liu H and He S: Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma. Oncol Rep 37: 622-630, 2017.
APA
Zhu, X., Ouyang, Y., Zhong, F., Wang, Q., Ding, L., Zhang, P. ... He, S. (2017). Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma. Oncology Reports, 37, 622-630. https://doi.org/10.3892/or.2016.5233
MLA
Zhu, X., Ouyang, Y., Zhong, F., Wang, Q., Ding, L., Zhang, P., Chen, L., Liu, H., He, S."Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma". Oncology Reports 37.1 (2017): 622-630.
Chicago
Zhu, X., Ouyang, Y., Zhong, F., Wang, Q., Ding, L., Zhang, P., Chen, L., Liu, H., He, S."Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma". Oncology Reports 37, no. 1 (2017): 622-630. https://doi.org/10.3892/or.2016.5233
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