Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis

  • Authors:
    • Jae Hyeon Kim
    • Min Su Kim
    • Bo Hee Lee
    • Jin-Kyu Kim
    • Eun-Kyung Ahn
    • Hye-Jin Ko
    • Young-Rak Cho
    • Sang-Jin Lee
    • Gyu-Un Bae
    • Yong Kee Kim
    • Joa Sub Oh
    • Dong-Wan Seo
  • View Affiliations

  • Published online on: November 15, 2016     https://doi.org/10.3892/or.2016.5245
  • Pages: 91-97
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Abstract

In the present study, we investigated the effects and molecular mechanism of marmesin, a natural coumarin compound isolated from Broussonetia kazinoki, on non-small cell lung cancer (NSCLC) cell responses and tumor angiogenesis. Marmesin abrogated mitogen-stimulated proliferation and invasion in both p53 wild-type A549 and p53-deficient H1299 NSCLC cells. These antitumor activities of marmesin were mediated by the inactivation of mitogenic signaling pathways and downregulation of cell signaling-related proteins including vascular endothelial growth factor receptor-2 (VEGFR-2), integrin β1, integrin-linked kinase and matrix metalloproteinases-2. Furthermore, marmesin suppressed the expression and secretion of VEGF in both NSCLC cells, leading to inhibition of capillary-like structure formation in human umbilical vein endothelial cells. Collectively, these findings demonstrate the pharmacological roles and molecular targets of marmesin in regulating NSCLC cell responses and tumor angiogenesis.
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January-2017
Volume 37 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kim JH, Kim MS, Lee BH, Kim J, Ahn E, Ko H, Cho Y, Lee S, Bae G, Kim YK, Kim YK, et al: Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis. Oncol Rep 37: 91-97, 2017
APA
Kim, J.H., Kim, M.S., Lee, B.H., Kim, J., Ahn, E., Ko, H. ... Seo, D. (2017). Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis. Oncology Reports, 37, 91-97. https://doi.org/10.3892/or.2016.5245
MLA
Kim, J. H., Kim, M. S., Lee, B. H., Kim, J., Ahn, E., Ko, H., Cho, Y., Lee, S., Bae, G., Kim, Y. K., Oh, J. S., Seo, D."Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis". Oncology Reports 37.1 (2017): 91-97.
Chicago
Kim, J. H., Kim, M. S., Lee, B. H., Kim, J., Ahn, E., Ko, H., Cho, Y., Lee, S., Bae, G., Kim, Y. K., Oh, J. S., Seo, D."Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis". Oncology Reports 37, no. 1 (2017): 91-97. https://doi.org/10.3892/or.2016.5245