|
1
|
Torre LA, Bray F, Siegel RL, Ferlay J,
Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA
Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Reck M, Heigener DF, Mok T, Soria J-C and
Rabe KF: Management of non-small-cell lung cancer: Recent
developments. Lancet. 382:709–719. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Gainor JF, Varghese AM, Ou S-HI, Kabraji
S, Awad MM, Katayama R, Pawlak A, Mino-Kenudson M, Yeap BY, Riely
GJ, et al: ALK rearrangements are mutually exclusive with mutations
in EGFR or KRAS: An analysis of 1,683 patients with non-small cell
lung cancer. Clin Cancer Res. 19:4273–4281. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Gasparini P, Cascione L, Landi L, Carasi
S, Lovat F, Tibaldi C, Alì G, D'Incecco A, Minuti G, Chella A, et
al: microRNA classifiers are powerful diagnostic/prognostic tools
in ALK-, EGFR-, and KRAS-driven lung cancers. Proc Natl Acad Sci
USA. 112:14924–14929. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Fong MY, Zhou W, Liu L, Alontaga AY,
Chandra M, Ashby J, Chow A, O'Connor ST, Li S, Chin AR, et al:
Breast-cancer-secreted miR-122 reprograms glucose metabolism in
premetastatic niche to promote metastasis. Nat Cell Biol.
17:183–194. 2015. View
Article : Google Scholar : PubMed/NCBI
|
|
6
|
Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo
F, Lyssiotis CA, Aldape K, Cantley LC and Lu Z: ERK1/2-dependent
phosphorylation and nuclear translocation of PKM2 promotes the
Warburg effect. Nat Cell Biol. 14:1295–1304. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Meijer TW, Kaanders JH, Span PN and
Bussink J: Targeting hypoxia, HIF-1, and tumor glucose metabolism
to improve radiotherapy efficacy. Clin Cancer Res. 18:5585–5594.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D
and Semenza GL: Hypoxia-inducible factor 1 (HIF-1) promotes
extracellular matrix remodeling under hypoxic conditions by
inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. J Biol
Chem. 288:10819–10829. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Li J, Xu Y, Long X-D, Wang W, Jiao HK, Mei
Z, Yin QQ, Ma LN, Zhou AW, Wang LS, et al: Cbx4 governs HIF-1α to
potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3
ligase activity. Cancer Cell. 25:118–131. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Pullamsetti SS, Banat GA, Schmall A,
Szibor M, Pomagruk D, Hänze J, Kolosionek E, Wilhelm J, Braun T,
Grimminger F, et al: Phosphodiesterase-4 promotes proliferation and
angiogenesis of lung cancer by crosstalk with HIF. Oncogene.
32:1121–1134. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Kaplon J, Zheng L, Meissl K, Chaneton B,
Selivanov VA, Mackay G, van der Burg SH, Verdegaal EM, Cascante M,
Shlomi T, et al: A key role for mitochondrial gatekeeper pyruvate
dehydrogenase in oncogene-induced senescence. Nature. 498:109–112.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Sutendra G, Kinnaird A, Dromparis P,
Paulin R, Stenson TH, Haromy A, Hashimoto K, Zhang N, Flaim E and
Michelakis ED: A nuclear pyruvate dehydrogenase complex is
important for the generation of acetyl-CoA and histone acetylation.
Cell. 158:84–97. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Sutendra G and Michelakis ED: Pyruvate
dehydrogenase kinase as a novel therapeutic target in oncology.
Front Oncol. 3:382013. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Hur H, Xuan Y, Kim YB, Lee G, Shim W, Yun
J, Ham IH and Han SU: Expression of pyruvate dehydrogenase kinase-1
in gastric cancer as a potential therapeutic target. Int J Oncol.
42:44–54. 2013.PubMed/NCBI
|
|
15
|
Schell JC, Olson KA, Jiang L, Hawkins AJ,
Van Vranken JG, Xie J, Egnatchik RA, Earl EG, DeBerardinis RJ and
Rutter J: A role for the mitochondrial pyruvate carrier as a
repressor of the Warburg effect and colon cancer cell growth. Mol
Cell. 56:400–413. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Qin L, Tian Y, Yu Z, Shi D, Wang J, Zhang
C, Peng R, Chen X, Liu C, Chen Y, et al: Targeting PDK1 with
dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell
growth. Oncotarget. 7:1395–1407. 2016.PubMed/NCBI
|
|
17
|
Koukourakis MI, Giatromanolaki A, Sivridis
E, Gatter KC and Harris AL: Tumor and Angiogenesis Research Group:
Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression
in non small cell lung cancer and tumor-associated stroma.
Neoplasia. 7:1–6. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Li T, Kung H-J, Mack PC and Gandara DR:
Genotyping and genomic profiling of non-small-cell lung cancer:
Implications for current and future therapies. J Clin Oncol.
31:1039–1049. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Cooper WA, Lam DC, O'Toole SA and Minna
JD: Molecular biology of lung cancer. J Thorac Dis. 5:(Suppl 5).
S479–S490. 2013.PubMed/NCBI
|
|
20
|
Shimizu T, Inoue K, Hachiya H, Shibuya N,
Shimoda M and Kubota K: Frequent alteration of the protein
synthesis of enzymes for glucose metabolism in hepatocellular
carcinomas. J Gastroenterol. 49:1324–1332. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Chiavarina B, Martinez-Outschoorn UE,
Whitaker-Menezes D, Howell A, Tanowitz HB, Pestell RG, Sotgia F and
Lisanti MP: Metabolic reprogramming and two-compartment tumor
metabolism: Opposing role(s) of HIF1α and HIF2α in tumor-associated
fibroblasts and human breast cancer cells. Cell Cycle.
11:3280–3289. 2012. View
Article : Google Scholar : PubMed/NCBI
|
|
22
|
Hou J, Aerts J, den Hamer B, van Ijcken W,
den Bakker M, Riegman P, van der Leest C, van der Spek P, Foekens
JA, Hoogsteden HC, et al: Gene expression-based classification of
non-small cell lung carcinomas and survival prediction. PLoS One.
5:e103122010. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Landi MT, Dracheva T, Rotunno M, Figueroa
JD, Liu H, Dasgupta A, Mann FE, Fukuoka J, Hames M, Bergen AW, et
al: Gene expression signature of cigarette smoking and its role in
lung adenocarcinoma development and survival. PLoS One.
3:e16512008. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Rousseaux S, Debernardi A, Jacquiau B,
Vitte A-L, Vesin A, Nagy-Mignotte H, Moro-Sibilot D, Brichon P-Y,
Lantuejoul S, Hainaut P, et al: Ectopic activation of germline and
placental genes identifies aggressive metastasis-prone lung
cancers. Sci Transl Med. 5:186ra166-186ra166. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Han L, Zhang G, Zhang N, Li H, Liu Y, Fu A
and Zheng Y: Prognostic potential of microRNA-138 and its target
mRNA PDK1 in sera for patients with non-small cell lung cancer. Med
Oncol. 31:1292014. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Martelli AM, Nyåkern M, Tabellini G,
Bortul R, Tazzari PL, Evangelisti C and Cocco L: Phosphoinositide
3-kinase/Akt signaling pathway and its therapeutical implications
for human acute myeloid leukemia. Leukemia. 20:911–928. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Kang S, Dong S, Gu T-L, Guo A, Cohen MS,
Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, et al:
FGFR3 activates RSK2 to mediate hematopoietic transformation
through tyrosine phosphorylation of RSK2 and activation of the
MEK/ERK pathway. Cancer Cell. 12:201–214. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Dann SG, Selvaraj A and Thomas G: mTOR
Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and
cancer. Trends Mol Med. 13:252–259. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Heiden MG Vander, Cantley LC and Thompson
CB: Understanding the Warburg effect: The metabolic requirements of
cell proliferation. Science. 324:1029–1033. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Upadhyay M, Samal J, Kandpal M, Singh OV
and Vivekanandan P: The Warburg effect: Insights from the past
decade. Pharmacol Ther. 137:318–330. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Yang F, Zhang H, Mei Y and Wu M:
Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the
Warburg effect. Mol Cell. 53:88–100. 2014. View Article : Google Scholar : PubMed/NCBI
|
