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Article

(-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway

  • Authors:
    • Yanli Gu
    • Jing Wang
    • Lixin Peng
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Daqing Oilfield General Hospital, Saertu, Daqing, Heilongjiang 163001, P.R. China
  • Pages: 483-491
    |
    Published online on: November 23, 2016
       https://doi.org/10.3892/or.2016.5270
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Abstract

Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore explored the effects of (-)-oleocanthal (OC) on the three processes in melanoma and investigated underlying mechanisms. In vitro, OC suppressed proliferation, migration, invasion and induced apoptosis in melanoma cells. In addition, OC inhibited proliferation, migration, invasion and tube formation in human umbilical vascular endothelial cells. In vivo, it exhibited potent activity in suppressing tumor growth in a subcutaneous xenograft model. Furthermore, OC suppressed proliferation and angiogenesis as measured by immunohistochemical staining of Ki-67 and CD31. In addition, OC was found to inhibit metastasis of melanoma in a lung metastasis model. Mechanistically, OC significantly suppressed signal transducer and activator of transcription 3 (STAT3) phosphorylation, decreased STAT3 nuclear localization and inhibited STAT3 transcriptional activity. OC also downregulated STAT3 target genes, including Mcl-1, Bcl-xL, MMP-2, MMP-9, VEGF, which are involved in apoptosis, invasion and angiogenesis of melanoma. These results support further investigation of OC as a potential anti-melanoma drug.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Cummins DL, Cummins JM, Pantle H, Silverman MA, Leonard AL and Chanmugam A: Cutaneous malignant melanoma. Mayo Clin Proc. 81:500–507. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Chi Z, Li S, Sheng X, Si L, Cui C, Han M and Guo J: Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese: A study of 522 consecutive cases. BMC Cancer. 11:852011. View Article : Google Scholar : PubMed/NCBI

4 

Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, Rutkowski P, Blank CU, Miller WH Jr, Kaempgen E, et al: Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial. Lancet. 380:358–365. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Callahan MK, Postow MA and Wolchok JD: Immunomodulatory therapy for melanoma: Ipilimumab and beyond. Clin Dermatol. 31:191–199. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Poust JC, Woolery JE and Green MR: Management of toxicities associated with high-dose interleukin-2 and biochemotherapy. Anticancer Drugs. 24:1–13. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Lopez-Bergami P, Fitchman B and Ronai Z: Understanding signaling cascades in melanoma. Photochem Photobiol. 84:289–306. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Kortylewski M, Jove R and Yu H: Targeting STAT3 affects melanoma on multiple fronts. Cancer Metastasis Rev. 24:315–327. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Xie TX, Huang FJ, Aldape KD, Kang SH, Liu M, Gershenwald JE, Xie K, Sawaya R and Huang S: Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res. 66:3188–3196. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Messina JL, Yu H, Riker AI, Munster PN, Jove RL and Daud AI: Activated stat-3 in melanoma. Cancer control. 15:196–201. 2008.PubMed/NCBI

11 

Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, et al: Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene. 21:2000–2008. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Liu L, Nam S, Tian Y, Yang F, Wu J, Wang Y, Scuto A, Polychronopoulos P, Magiatis P, Skaltsounis L, et al: 6-Bromoindirubin-3-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer Res. 71:3972–3979. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Liu L, Kritsanida M, Magiatis P, Gaboriaud N, Wang Y, Wu J, Buettner R, Yang F, Nam S, Skaltsounis L, et al: A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling. Cancer Biol Ther. 13:1255–1261. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Kamran MZ and Gude RP: Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway. Biomed Pharmacother. 67:399–405. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Martínez ME, Marshall JR and Giovannucci E: Diet and cancer prevention: The roles of observation and experimentation. Nat Rev Cancer. 8:694–703. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Tong LX and Young LC: Nutrition: The future of melanoma prevention? J Am Acad Dermatol. 71:151–160. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Fortes C, Forastiere F, Farchi S, Mallone S, Trequattrinni T, Anatra F, Schmid G and Perucci CA: The protective effect of the Mediterranean diet on lung cancer. Nutr Cancer. 46:30–37. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Bosetti C, Negri E, Franceschi S, Talamini R, Montella M, Conti E, Lagiou P, Parazzini F and La Vecchia C: Olive oil, seed oils and other added fats in relation to ovarian cancer (Italy). Cancer Causes Control. 13:465–470. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Monti MC, Margarucci L, Tosco A, Riccio R and Casapullo A: New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component. Food Funct. 2:423–428. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Monti MC, Margarucci L, Riccio R and Casapullo A: Modulation of tau protein fibrillization by oleocanthal. J Nat Prod. 75:1584–1588. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Lucas L, Russell A and Keast R: Molecular mechanisms of inflammation. Anti-inflammatory benefits of virgin olive oil and the phenolic compound oleocanthal. Curr Pharm Des. 17:754–768. 2011.

22 

Cicerale S, Breslin PA, Beauchamp GK and Keast RS: Sensory characterization of the irritant properties of oleocanthal, a natural anti-inflammatory agent in extra virgin olive oils. Chem Senses. 34:333–339. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Romero C, Medina E, Vargas J, Brenes M and De Castro A: In vitro activity of olive oil polyphenols against Helicobacter pylori. J Agric Food Chem. 55:680–686. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Busnena BA, Foudah AI, Melancon T and El Sayed KA: Olive secoiridoids and semisynthetic bioisostere analogues for the control of metastatic breast cancer. Bioorg Med Chem. 21:2117–2127. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Akl MR, Ayoub NM, Mohyeldin MM, Busnena BA, Foudah AI, Liu YY and Sayed KA: Olive phenolics as c-Met inhibitors: (−)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models. PLoS One. 9:e976222014. View Article : Google Scholar : PubMed/NCBI

26 

Elnagar AY, Sylvester PW and El Sayed KA: (−)-Oleocanthal as a c-Met inhibitor for the control of metastatic breast and prostate cancers. Planta Med. 77:1013–1019. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Scotece M, Gómez R, Conde J, Lopez V, Gómez-Reino JJ, Lago F, Smith AB III and Gualillo O: Oleocanthal inhibits proliferation and MIP-1α expression in human multiple myeloma cells. Curr Med Chem. 20:2467–2475. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Pei T, Meng Q, Han J, Li HS, Song R, Sun B, Pan S, Liang D and Liu L: (−)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma. Oncotarget. Jun 2–2016.(Epub ahead of print).

29 

Smith AB III, Han Q, Breslin PA and Beauchamp GK: Synthesis and assignment of absolute configuration of (−)-oleocanthal: A potent, naturally occurring non-steroidal anti-inflammatory and anti-oxidant agent derived from extra virgin olive oils. Org Lett. 7:5075–5078. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Song R, Song H, Liang Y, Yin D, Zhang H, Zheng T, Wang J, Lu Z, Song X, Pei T, et al: Reciprocal activation between ATPase inhibitory factor 1 and NF-κB drives hepatocellular carcinoma angiogenesis and metastasis. Hepatology. 60:1659–1673. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Ferrara N and Kerbel RS: Angiogenesis as a therapeutic target. Nature. 438:967–974. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Al Zaid Siddiquee K and Turkson J: STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res. 18:254–267. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Fan TP, Yeh JC, Leung KW, Yue PY and Wong RN: Angiogenesis: From plants to blood vessels. Trends Pharmacol Sci. 27:297–309. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Tournaire R, Simon MP, le Noble F, Eichmann A, England P and Pouysségur J: A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor. EMBO Rep. 5:262–267. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Hartman ML and Czyz M: Anti-apoptotic proteins on guard of melanoma cell survival. Cancer Lett. 331:24–34. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Zhuang L, Lee CS, Scolyer RA, McCarthy SW, Zhang XD, Thompson JF and Hersey P: Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma. Mod Pathol. 20:416–426. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Niu G, Bowman T, Huang M, Shivers S, Reintgen D, Daud A, Chang A, Kraker A, Jove R and Yu H: Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene. 21:7001–7010. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Ascierto PA, Leonardi E, Ottaiano A, Napolitano M, Scala S and Castello G: Prognostic value of serum VEGF in melanoma patients: A pilot study. Anticancer Res. 24:4255–4258. 2004.PubMed/NCBI

39 

Rotte A, Martinka M and Li G: MMP2 expression is a prognostic marker for primary melanoma patients. Cell Oncol (Dordr). 35:207–216. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Nikkola J, Vihinen P, Vuoristo MS, Kellokumpu-Lehtinen P, Kähäri VM and Pyrhönen S: High serum levels of matrix metalloproteinase-9 and matrix metalloproteinase-1 are associated with rapid progression in patients with metastatic melanoma. Clin Cancer Res. 11:5158–5166. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R and Huang S: Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene. 23:3550–3560. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gu Y, Wang J and Peng L: (-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway. Oncol Rep 37: 483-491, 2017.
APA
Gu, Y., Wang, J., & Peng, L. (2017). (-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway. Oncology Reports, 37, 483-491. https://doi.org/10.3892/or.2016.5270
MLA
Gu, Y., Wang, J., Peng, L."(-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway". Oncology Reports 37.1 (2017): 483-491.
Chicago
Gu, Y., Wang, J., Peng, L."(-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway". Oncology Reports 37, no. 1 (2017): 483-491. https://doi.org/10.3892/or.2016.5270
Copy and paste a formatted citation
x
Spandidos Publications style
Gu Y, Wang J and Peng L: (-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway. Oncol Rep 37: 483-491, 2017.
APA
Gu, Y., Wang, J., & Peng, L. (2017). (-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway. Oncology Reports, 37, 483-491. https://doi.org/10.3892/or.2016.5270
MLA
Gu, Y., Wang, J., Peng, L."(-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway". Oncology Reports 37.1 (2017): 483-491.
Chicago
Gu, Y., Wang, J., Peng, L."(-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway". Oncology Reports 37, no. 1 (2017): 483-491. https://doi.org/10.3892/or.2016.5270
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