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Article

Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53

  • Authors:
    • Jiansen Li
    • Xiangqian Zheng
    • Ming Gao
    • Jingzhu Zhao
    • Yigong Li
    • Xiangrui Meng
    • Biyun Qian
    • Jiafeng Li
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin National Clinical Research Center for Cancer, Tianjin 300060, P.R. China, Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin National Clinical Research Center for Cancer, Tianjin 300060, P.R. China, Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin National Clinical Research Center for Cancer, Tianjin 300060, P.R. China, Department of Epidemiology, School of Public Health, Shanghai Jiao Tong University, Shanghai 200030, P.R. China
  • Pages: 458-464
    |
    Published online on: November 29, 2016
       https://doi.org/10.3892/or.2016.5281
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Abstract

Anaplastic thyroid cancer (ATC), usually derived from well-differentiated thyroid cancers is one of the most lethal human endocrine malignancies. In the present study, we report that in human ATC tumor tissue samples exist undetectable Notch1 and the active Notch1 intracellular domain could not be detected in ATC-CAL-62 cells. Interesting, suberoyl bis-hydroxamic acid (SBHA) administration could induce Notch1 intracellular domain levels in a dose-dependent manner, coupled with the increase of p53 and p21. Furthermore, ectopic expression of Notch1 or deletion of p53 with small-interfering RNA was able to abolish the effects of SBHA to elevation of Notch1 and p53 in ATC cells. As a result, SBHA treatment efficiently induced ATC cell apoptosis. These results indicate that SBHA may play antitumor functions via regulating Notch1/p53 signals, and highlight that SBHA could have clinical potential to benefit the therapy of ATC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Zheng X, Gao M, Zhao J, Li Y, Meng X, Qian B and Li J: Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53. Oncol Rep 37: 458-464, 2017.
APA
Li, J., Zheng, X., Gao, M., Zhao, J., Li, Y., Meng, X. ... Li, J. (2017). Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53. Oncology Reports, 37, 458-464. https://doi.org/10.3892/or.2016.5281
MLA
Li, J., Zheng, X., Gao, M., Zhao, J., Li, Y., Meng, X., Qian, B., Li, J."Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53". Oncology Reports 37.1 (2017): 458-464.
Chicago
Li, J., Zheng, X., Gao, M., Zhao, J., Li, Y., Meng, X., Qian, B., Li, J."Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53". Oncology Reports 37, no. 1 (2017): 458-464. https://doi.org/10.3892/or.2016.5281
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Zheng X, Gao M, Zhao J, Li Y, Meng X, Qian B and Li J: Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53. Oncol Rep 37: 458-464, 2017.
APA
Li, J., Zheng, X., Gao, M., Zhao, J., Li, Y., Meng, X. ... Li, J. (2017). Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53. Oncology Reports, 37, 458-464. https://doi.org/10.3892/or.2016.5281
MLA
Li, J., Zheng, X., Gao, M., Zhao, J., Li, Y., Meng, X., Qian, B., Li, J."Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53". Oncology Reports 37.1 (2017): 458-464.
Chicago
Li, J., Zheng, X., Gao, M., Zhao, J., Li, Y., Meng, X., Qian, B., Li, J."Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53". Oncology Reports 37, no. 1 (2017): 458-464. https://doi.org/10.3892/or.2016.5281
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