Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
February-2017 Volume 37 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2017 Volume 37 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Lung cancer gene therapy: Transferrin and hyaluronic acid dual ligand-decorated novel lipid carriers for targeted gene delivery

  • Authors:
    • Bin Zhang
    • Yueying Zhang
    • Dongmei Yu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Shandong Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China, Department of Experimental Pathology, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, P.R. China, Department of Public Health, Shandong Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China
  • Pages: 937-944
    |
    Published online on: December 7, 2016
       https://doi.org/10.3892/or.2016.5298
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

To achieve lung cancer gene therapy, nanocarriers decorated with different ligands were used. Surface decoration and nanoparticulate system will assist in targeting the gene to specific cells and tissues, such as cancers and diseased organs. The aim of this research was to develop a dual ligand-decorated nanocarriers, which could target the tumor cells through receptor-mediated pathways to increase the uptake of genetic materials. Transferrin (Tf) and hyaluronic (HA) containing polyethylene glycol-distearoylphosphatidylethanolamine (Tf-PEG-DSPE and HA-PEG-DSPE) ligands were synthesized. Novel Tf and HA ligand-decorated, plasmid-enhanced green fluorescent protein loaded nanostructured lipid carriers (Tf/HA-pDNA NLC) was constructed. Physicochemical properties such as morphology, size, and ζ-potential as well as release properties were evaluated. The in vitro and in vivo gene transfection efficiency of Tf/HA-pDNA NLC was evaluated in lung adenocarcinoma A549 cells and lung cancer bearing animal models. Tf/HA-pDNA NLC displayed significantly higher transfection efficiency than undecorated DNA-NLCs and single ligand-decorated NLCs in vitro and in vivo. The newly constructed NLCs could successfully load gene; and Tf and HA functioned as excellent targeting ligands to improve the cell targeting ability of the gene-loaded nanocarriers. The resulting dual ligands decorated vectors could be a promising targeted gene delivery system for the lung cancer treatment.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Poulsen TT, Pedersen N and Poulsen HS: Replacement and suicide gene therapy for targeted treatment of lung cancer. Clin Lung Cancer. 6:227–236. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Stuckey DW and Shah K: Stem cell-based therapies for cancer treatment: Separating hope from hype. Nat Rev Cancer. 14:683–691. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Zhang TY, Huang B, Wu HB, Wu JH, Li LM, Li YX, Hu YL, Han M, Shen YQ, Tabata Y, et al: Synergistic effects of co-administration of suicide gene expressing mesenchymal stem cells and prodrug-encapsulated liposome on aggressive lung melanoma metastases in mice. J Control Release. 209:260–271. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Cho WY, Hong SH, Singh B, Islam MA, Lee S, Lee AY, Gankhuyag N, Kim JE, Yu KN, Kim KH, et al: Suppression of tumor growth in lung cancer xenograft model mice by poly(sorbitol-co-PEI)-mediated delivery of osteopontin siRNA. Eur J Pharm Biopharm. 94:450–462. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Kim I, Byeon HJ, Kim TH, Lee ES, Oh KT, Shin BS, Lee KC and Youn YS: Doxorubicin-loaded porous PLGA microparticles with surface attached TRAIL for the inhalation treatment of metastatic lung cancer. Biomaterials. 34:6444–6453. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Merdan T, Kopecek J and Kissel T: Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv Drug Deliv Rev. 54:715–758. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Xie RL, Jang YJ, Xing L, Zhang BF, Wang FZ, Cui PF, Cho MH and Jiang HL: A novel potential biocompatible hyperbranched polyspermine for efficient lung cancer gene therapy. Int J Pharm. 478:19–30. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Christensen CL, Zandi R, Gjetting T, Cramer F and Poulsen HS: Specifically targeted gene therapy for small-cell lung cancer. Expert Rev Anticancer Ther. 9:437–452. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Chen Y, Gao DY and Huang L: In vivo delivery of miRNAs for cancer therapy: Challenges and strategies. Adv Drug Deliv Rev. 81:128–141. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Chen Y, Zhu X, Zhang X, Liu B and Huang L: Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Mol Ther. 18:1650–1656. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Lennox KA and Behlke MA: Chemical modification and design of anti-miRNA oligonucleotides. Gene Ther. 18:1111–1120. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Tivnan A, Orr WS, Gubala V, Nooney R, Williams DE, McDonagh C, Prenter S, Harvey H, Domingo-Fernández R, Bray IM, et al: Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. PLoS One. 7:e381292012. View Article : Google Scholar : PubMed/NCBI

14 

Heger Z, Gumulec J, Cernei N, Tmejova K, Kopel P, Balvan J, Masarik M, Zitka O, Beklova M, Adam V, et al: 17β-estradiol-containing liposomes as a novel delivery system for the antisense therapy of ER-positive breast cancer: An in vitro study on the MCF-7 cell line. Oncol Rep. 33:921–9. 2015.PubMed/NCBI

15 

de Jesus MB and Zuhorn IS: Solid lipid nanoparticles as nucleic acid delivery system: Properties and molecular mechanisms. J Control Release. 201:1–13. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Zhang Z, Sha X, Shen A, Wang Y, Sun Z, Gu Z and Fang X: Polycation nanostructured lipid carrier, a novel nonviral vector constructed with triolein for efficient gene delivery. Biochem Biophys Res Commun. 370:478–482. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Doktorovova S, Souto EB and Silva AM: Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers - a systematic review of in vitro data. Eur J Pharm Biopharm. 87:1–18. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Han Y, Zhang Y, Li D, Chen Y, Sun J and Kong F: Transferrin-modified nanostructured lipid carriers as multifunctional nanomedicine for codelivery of DNA and doxorubicin. Int J Nanomed. 9:4107–4116. 2014.

19 

Avitabile T, Marano F, Castiglione F, Bucolo C, Cro M, Ambrosio L, Ferrauto C and Reibaldi A: Biocompatibility and biodegradation of intravitreal hyaluronan implants in rabbits. Biomaterials. 22:195–200. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Fang XJ, Jiang H, Zhu YQ, Zhang LY, Fan QH and Tian Y: Doxorubicin induces drug resistance and expression of the novel CD44st via NF-κB in human breast cancer MCF-7 cells. Oncol Rep. 31:2735–2742. 2014.PubMed/NCBI

21 

Coradini D, Pellizzaro C, Abolafio G, Bosco M, Scarlata I, Cantoni S, Stucchi L, Zorzet S, Turrin C, Sava G, et al: Hyaluronic-acid butyric esters as promising antineoplastic agents in human lung carcinoma: A preclinical study. Invest New Drugs. 22:207–217. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Pan J, Sun SK, Wang Y, Fu YY, Zhang X, Zhang Y and Yu C: Facile preparation of hyaluronic acid and transferrin co-modified Fe3O4 nanoparticles with inherent biocompatibility for dual-targeting magnetic resonance imaging of tumors in vivo. Dalton Trans. 44:19836–19843. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Kondo H, Miyoshi K, Sakiyama S, Tangoku A and Noma T: Differential regulation of gene expression of alveolar epithelial cell markers in human lung adenocarcinoma-derived A549 clones. Stem Cells Int. 2015:1658672015. View Article : Google Scholar : PubMed/NCBI

24 

Wang W, Zhou F, Ge L, Liu X and Kong F: Transferrin-PEG-PE modified dexamethasone conjugated cationic lipid carrier mediated gene delivery system for tumor-targeted transfection. Int J Nanomed. 7:2513–2522. 2012.

25 

Jing L, Shao S, Wang Y, Yang Y, Yue X and Dai Z: Hyaluronic acid modified hollow Prussian blue nanoparticles loading 10-hydroxycamptothecin for targeting thermochemotherapy of cancer. Theranostics. 6:40–53. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zhang XG, Miao J, Dai YQ, Du YZ, Yuan H and Hu FQ: Reversal activity of nanostructured lipid carriers loading cytotoxic drug in multi-drug resistant cancer cells. Int J Pharm. 361:239–244. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Du YZ, Cai LL, Li J, Zhao MD, Chen FY, Yuan H and Hu FQ: Receptor-mediated gene delivery by folic acid-modified stearic acid-grafted chitosan micelles. Int J Nanomed. 6:1559–1568. 2011. View Article : Google Scholar

28 

Yu W, Liu C, Liu Y, Zhang N and Xu W: Mannan-modified solid lipid nanoparticles for targeted gene delivery to alveolar macrophages. Pharm Res. 27:1584–1596. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Wang RH, Cao HM, Tian ZJ, Jin B, Wang Q, Ma H and Wu J: Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer. Oncol Rep. 33:783–791. 2015.PubMed/NCBI

30 

Yu W, Liu C, Ye J, Zou W, Zhang N and Xu W: Novel cationic SLN containing a synthesized single-tailed lipid as a modifier for gene delivery. Nanotechnology. 20:2151022009. View Article : Google Scholar : PubMed/NCBI

31 

Pepić I, Lovrić J, Hafner A and Filipović-Grčić J: Powder form and stability of Pluronic mixed micelle dispersions for drug delivery applications. Drug Dev Ind Pharm. 40:944–951. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Yu X, Yang G, Shi Y, Su C, Liu M, Feng B and Zhao L: Intracellular targeted co-delivery of shMDR1 and gefitinib with chitosan nanoparticles for overcoming multidrug resistance. Int J Nanomed. 10:7045–7056. 2015.

33 

Zou W, Liu C, Chen Z and Zhang N: Studies on bioadhesive PLGA nanoparticles: A promising gene delivery system for efficient gene therapy to lung cancer. Int J Pharm. 370:187–195. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Vighi E, Montanari M, Hanuskova M, Iannuccelli V, Coppi G and Leo E: Design flexibility influencing the in vitro behavior of cationic SLN as a nonviral gene vector. Int J Pharm. 440:161–169. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Hazzah HA, Farid RM, Nasra MM, El-Massik MA and Abdallah OY: Lyophilized sponges loaded with curcumin solid lipid nanoparticles for buccal delivery: Development and characterization. Int J Pharm. 492:248–257. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Wang L, Dong J, Ouyang W, Wang X and Tang J: Anticancer effect and feasibility study of hyperthermia treatment of pancreatic cancer using magnetic nanoparticles. Oncol Rep. 27:719–726. 2012.PubMed/NCBI

37 

Kumar MN Ravi, Bakowsky U and Lehr CM: Preparation and characterization of cationic PLGA nanospheres as DNA carriers. Biomaterials. 25:1771–1777. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Immordino ML, Brusa P, Rocco F, Arpicco S, Ceruti M and Cattel L: Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs. J Control Release. 100:331–346. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Song RF, Li XJ, Cheng XL, Fu AR, Wang YH, Feng YJ and Xiong Y: Paclitaxel-loaded trimethyl chitosan-based polymeric nanoparticle for the effective treatment of gastroenteric tumors. Oncol Rep. 32:1481–1488. 2014.PubMed/NCBI

40 

Torchilin VP: Multifunctional nanocarriers. Adv Drug Deliv Rev. 58:1532–1555. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Kamiya H, Tsuchiya H, Yamazaki J and Harashima H: Intracellular trafficking and transgene expression of viral and non-viral gene vectors. Adv Drug Deliv Rev. 52:153–164. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Jiang HL, Hong SH, Kim YK, Islam MA, Kim HJ, Choi YJ, Nah JW, Lee KH, Han KW, Chae C, et al: Aerosol delivery of spermine-based poly(amino ester)/Akt1 shRNA complexes for lung cancer gene therapy. Int J Pharm. 420:256–265. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang B, Zhang Y and Yu D: Lung cancer gene therapy: Transferrin and hyaluronic acid dual ligand-decorated novel lipid carriers for targeted gene delivery. Oncol Rep 37: 937-944, 2017.
APA
Zhang, B., Zhang, Y., & Yu, D. (2017). Lung cancer gene therapy: Transferrin and hyaluronic acid dual ligand-decorated novel lipid carriers for targeted gene delivery. Oncology Reports, 37, 937-944. https://doi.org/10.3892/or.2016.5298
MLA
Zhang, B., Zhang, Y., Yu, D."Lung cancer gene therapy: Transferrin and hyaluronic acid dual ligand-decorated novel lipid carriers for targeted gene delivery". Oncology Reports 37.2 (2017): 937-944.
Chicago
Zhang, B., Zhang, Y., Yu, D."Lung cancer gene therapy: Transferrin and hyaluronic acid dual ligand-decorated novel lipid carriers for targeted gene delivery". Oncology Reports 37, no. 2 (2017): 937-944. https://doi.org/10.3892/or.2016.5298
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang B, Zhang Y and Yu D: Lung cancer gene therapy: Transferrin and hyaluronic acid dual ligand-decorated novel lipid carriers for targeted gene delivery. Oncol Rep 37: 937-944, 2017.
APA
Zhang, B., Zhang, Y., & Yu, D. (2017). Lung cancer gene therapy: Transferrin and hyaluronic acid dual ligand-decorated novel lipid carriers for targeted gene delivery. Oncology Reports, 37, 937-944. https://doi.org/10.3892/or.2016.5298
MLA
Zhang, B., Zhang, Y., Yu, D."Lung cancer gene therapy: Transferrin and hyaluronic acid dual ligand-decorated novel lipid carriers for targeted gene delivery". Oncology Reports 37.2 (2017): 937-944.
Chicago
Zhang, B., Zhang, Y., Yu, D."Lung cancer gene therapy: Transferrin and hyaluronic acid dual ligand-decorated novel lipid carriers for targeted gene delivery". Oncology Reports 37, no. 2 (2017): 937-944. https://doi.org/10.3892/or.2016.5298
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team