Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme (Review)

  • Authors:
    • Gang Wang
    • Jun-Jie Wang
    • Xing-Li Fu
    • Rui Guang
    • Shing-Shun Tony To
  • View Affiliations

  • Published online on: December 9, 2016     https://doi.org/10.3892/or.2016.5309
  • Pages: 657-670
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Abstract

Cell metabolism can be reprogrammed by tissue hypoxia leading to cell transformation and glioblastoma multiforme (GBM) progression. In response to hypoxia, GBM cells are able to express a transcription factor called hypoxia inducible factor-1 (HIF-1). HIF-1 belongs to a family of heterodimeric proteins that includes HIF-1α and HIF-1β subunits. HIF-1α has been reported to play a pivotal role in GBM development and progression. In the present review, we discuss the role of HIF-1α in glucose uptake, cancer proliferation, cell mobility and chemoresistance in GBM. Evidence from previous studies indicates that HIF-1α regulates angiogenesis, metabolic and transcriptional signaling pathways. Examples of such are the EGFR, PI3K/Akt and MAPK/ERK pathways. It affects cell migration and invasion by regulating glucose metabolism and growth in GBM cells. The present review focuses on the strategies through which to target HIF-1α and the related downstream genes highlighting their regulatory roles in angiogenesis, apoptosis, migration and glucose metabolism for the development of future GBM therapeutics. Combined treatment with inhibitors of HIF-1α and glycolysis may enhance antitumor effects in clinical settings.
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February-2017
Volume 37 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wang G, Wang J, Fu X, Guang R and To ST: Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme (Review). Oncol Rep 37: 657-670, 2017
APA
Wang, G., Wang, J., Fu, X., Guang, R., & To, S.T. (2017). Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme (Review). Oncology Reports, 37, 657-670. https://doi.org/10.3892/or.2016.5309
MLA
Wang, G., Wang, J., Fu, X., Guang, R., To, S. T."Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme (Review)". Oncology Reports 37.2 (2017): 657-670.
Chicago
Wang, G., Wang, J., Fu, X., Guang, R., To, S. T."Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme (Review)". Oncology Reports 37, no. 2 (2017): 657-670. https://doi.org/10.3892/or.2016.5309