miR-367 promotes the proliferation and invasion of non-small cell lung cancer via targeting FBXW7

  • Authors:
    • Jing Xu
    • Weibing Wu
    • Jun Wang
    • Chenjun Huang
    • Wei Wen
    • Fei Zhao
    • Xinfeng Xu
    • Xianglong Pan
    • Wei Wang
    • Quan Zhu
    • Liang Chen
  • View Affiliations

  • Published online on: December 14, 2016     https://doi.org/10.3892/or.2016.5314
  • Pages: 1052-1058
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Abstract

The involvement of miR-367 in lung cancer development remains unclear. In the present study, we analyzed the expression of miR-367 in tumor and adjacent tissue samples from 113 patients with non-small cell lung cancer (NSCLC) utilizing real-time PCR. miR-367 expression was significantly upregulated in the cancer tissues compared with non-cancer controls. Based on the median value of the miR-367 expression level, we divided the NSCLC patients into miR-367 high-expression and miR-367 low-expression groups. Overexpression of miR-367 was correlated with a poorer prognosis of NSCLC patients Chi-square (χ2) test showed a significant statistical correlation between tumor size, tumor stage, metastasis and miR-367 expression. Additionally, miR-367 expression was found to be negatively correlated with FBXW7 expression. Based on the above correlations, we performed a series of functional experiments to further confirm the effect of miR-367 on NSCLC. Our results indicated that miR-367 may be involved in the development and progression of NSCLC by promoting proliferation and invasion and impeding apoptosis in NSCLC cells. Furthermore, FBXW7 was identified as a potential target of miR-367, and FBXW7 silencing partially compromised the invasive, proliferative and migratory capacities in the cells with low miR-367 expression. Thus, the miR-367/FBXW7 axis may be involved in the development and progression of NSCLC and may be valuable as a therapeutic target for the treatment of human NSCLC, especially cancers with high invasive potential.
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February-2017
Volume 37 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Xu J, Wu W, Wang J, Huang C, Wen W, Zhao F, Xu X, Pan X, Wang W, Zhu Q, Zhu Q, et al: miR-367 promotes the proliferation and invasion of non-small cell lung cancer via targeting FBXW7. Oncol Rep 37: 1052-1058, 2017
APA
Xu, J., Wu, W., Wang, J., Huang, C., Wen, W., Zhao, F. ... Chen, L. (2017). miR-367 promotes the proliferation and invasion of non-small cell lung cancer via targeting FBXW7. Oncology Reports, 37, 1052-1058. https://doi.org/10.3892/or.2016.5314
MLA
Xu, J., Wu, W., Wang, J., Huang, C., Wen, W., Zhao, F., Xu, X., Pan, X., Wang, W., Zhu, Q., Chen, L."miR-367 promotes the proliferation and invasion of non-small cell lung cancer via targeting FBXW7". Oncology Reports 37.2 (2017): 1052-1058.
Chicago
Xu, J., Wu, W., Wang, J., Huang, C., Wen, W., Zhao, F., Xu, X., Pan, X., Wang, W., Zhu, Q., Chen, L."miR-367 promotes the proliferation and invasion of non-small cell lung cancer via targeting FBXW7". Oncology Reports 37, no. 2 (2017): 1052-1058. https://doi.org/10.3892/or.2016.5314