|
1
|
Peng G, Wang T, Yang KY, Zhang S, Zhang T,
Li Q, Han J and Wu G: A prospective, randomized study comparing
outcomes and toxicities of intensity-modulated radiotherapy vs.
conventional two-dimensional radiotherapy for the treatment of
nasopharyngeal carcinoma. Radiother Oncol. 104:286–293. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Wang R, Wu F, Lu H, Wei B, Feng G, Li G,
Liu M, Yan H, Zhu J, Zhang Y, et al: Definitive intensity-modulated
radiation therapy for nasopharyngeal carcinoma: Long-term outcome
of a multicenter prospective study. J Cancer Res Clin Oncol.
139:139–145. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Yang CF, Peng LX, Huang TJ, Yang GD, Chu
QQ, Liang YY, Cao X, Xie P, Zheng LS, Huang HB, et al: Cancer
stem-like cell characteristics induced by EB virus-encoded LMP1
contribute to radioresistance in nasopharyngeal carcinoma by
suppressing the p53-mediated apoptosis pathway. Cancer Lett.
344:260–271. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Wang WJ, Wu SP, Liu JB, Shi YS, Huang X,
Zhang QB and Yao KT: MYC regulation of CHK1 and CHK2 promotes
radioresistance in a stem cell-like population of nasopharyngeal
carcinoma cells. Cancer Res. 73:1219–1231. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Wei P, Niu M, Pan S, Zhou Y, Shuai C, Wang
J, Peng S and Li G: Cancer stem-like cell: A novel target for
nasopharyngeal carcinoma therapy. Stem Cell Res Ther. 5:442014.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Zhu Y, Liu H, Xu L, An H, Liu W, Liu Y,
Lin Z and Xu J: p21-activated kinase 1 determines stem-like
phenotype and sunitinib resistance via NF-κB/IL-6 activation in
renal cell carcinoma. Cell Death Dis. 6:e16372015. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Vinogradov S and Wei X: Cancer stem cells
and drug resistance: The potential of nanomedicine. Nanomedicine
(Lond). 7:597–615. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Meijer TW, Kaanders JH, Span PN and
Bussink J: Targeting hypoxia, HIF-1, and tumor glucose metabolism
to improve radiotherapy efficacy. Clin Cancer Res. 18:5585–5594.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Scholz CC, von Kriegsheim A, Tambuwala MM,
Hams E, Cheong A, Bruning U, Fallon PG, Cummins EP and Taylor CT:
Prolyl Hydroxylase 1 (PHD1) and Factor Inhibiting HIF (FIH)
regulate IL-1β-induced NF-κB activity linking key hypoxic and
inflammatory signaling pathways. FASEB J. 27:717–719. 2013.
|
|
10
|
Wong JH, Lui VW, Umezawa K, Ho Y, Wong EY,
Ng MH, Cheng SH, Tsang CM, Tsao SW and Chan AT: A small molecule
inhibitor of NF-kappaB, dehydroxymethylepoxyquinomicin (DHMEQ),
suppresses growth and invasion of nasopharyngeal carcinoma (NPC)
cells. Cancer Lett. 287:23–32. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Kan R, Shuen WH, Lung HL, Cheung AK, Dai
W, Kwong DL, Ng WT, Lee AW, Yau CC, Ngan RK, et al: NF-κB p65
subunit is modulated by Latent Transforming Growth Factor-β Binding
Protein 2 (LTBP2) in nasopharyngeal carcinoma HONE1 and HK1 cells.
PLoS One. 10:e01272392015. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Li CW, Xia W, Huo L, Lim SO, Wu Y, Hsu JL,
Chao CH, Yamaguchi H, Yang NK, Ding Q, et al:
Epithelial-mesenchymal transition induced by TNF-α requires
NF-κB-mediated transcriptional upregulation of Twist1. Cancer Res.
72:1290–1300. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Zhao D, Tang XF, Yang K, Liu JY and Ma XR:
Over-expression of integrin-linked kinase correlates with aberrant
expression of Snail, E-cadherin and N-cadherin in oral squamous
cell carcinoma: Implications in tumor progression and metastasis.
Clin Exp Metastasis. 29:957–969. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Kambhampati S, Rajewski RA, Tanol M, Haque
I, Das A, Banerjee S, Jha S, Burns D, Borrego-Diaz E, Van
Veldhuizen PJ, et al: A second-generation 2-Methoxyestradiol
prodrug is effective against Barrett's adenocarcinoma in a mouse
xenograft model. Mol Cancer Ther. 12:255–263. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Zhang XY, Zhan R, Huang HB and Yang T:
Mechanism underlying 2-methoxyestradiol inducing apoptosis of K562
cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 17:340–344. 2009.(In
Chinese). PubMed/NCBI
|
|
16
|
Kumar AP, Garcia GE, Orsborn J, Levin VA
and Slaga TJ: 2-Methoxyestradiol interferes with NFκB
transcriptional activity in primitive neuroectodermal brain tumors:
Implications for management. Carcinogenesis. 24:209–216. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Parrondo R, de las Pozas A, Reiner T, Rai
P and Perez-Stable C: NF-κB activation enhances cell death by
antimitotic drugs in human prostate cancer cells. Mol Cancer.
9:1822010. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Semenza GL: Hypoxia-inducible factors:
Mediators of cancer progression and targets for cancer therapy.
Trends Pharmacol Sci. 33:207–214. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Marie-Egyptienne DT, Lohse I and Hill RP:
Cancer stem cells, the epithelial to mesenchymal transition (EMT)
and radioresistance: Potential role of hypoxia. Cancer Lett.
341:63–72. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Conley SJ, Baker TL, Burnet JP, Thiesen
RL, Lazarus D, Peters CG, Clouthier SG, Eliasof S and Wicha MS:
CRLX101, an investigational camptothecin-containing
nanoparticle-drug conjugate, reverses the HIF-1α-mediated increase
in cancer stem cells caused by bevacizumab in a preclinical model
of triple-negative breast cancer. Cancer Res. 75:(Suppl 15).
13842015. View Article : Google Scholar
|
|
21
|
Kazi AA, Shah P, Schech A, Sabnis G,
Chumsri S and Brodie A: Inhibition of non-hypoxic HIF-1 expression
in letrozole-resistant breast cancer cells reduces their cancer
stem cell characteristics. Cancer Res. 73:(Suppl 8). 952013.
View Article : Google Scholar
|
|
22
|
Gammon L and Mackenzie IC: Roles of
hypoxia, stem cells and epithelial-mesenchymal transition in the
spread and treatment resistance of head and neck cancer. J Oral
Pathol Med. 45:77–82. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Ricker JL, Chen Z, Yang XP, Pribluda VS,
Swartz GM and Van Waes C: 2-methoxyestradiol inhibits
hypoxia-inducible factor 1α, tumor growth, and angiogenesis and
augments paclitaxel efficacy in head and neck squamous cell
carcinoma. Clin Cancer Res. 10:8665–8673. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Li YJ, Wu SL, Lu SM, Chen F, Guo Y, Gan
SM, Shi YL, Liu S and Li SL: (−)-Epigallocatechin-3-gallate
inhibits nasopharyngeal cancer stem cell self-renewal and migration
and reverses the epithelial-mesenchymal transition via NF-κB p65
inactivation. Tumour Biol. 36:2747–2761. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Fan X, Liu S, Su F, Pan Q and Lin T:
Effective enrichment of prostate cancer stem cells from spheres in
a suspension culture system. Urol Oncol. 30:314–318. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Chen SF, Chang YC, Nieh S, Liu CL, Yang CY
and Lin YS: Nonadhesive culture system as a model of rapid sphere
formation with cancer stem cell properties. PLoS One. 7:e318642012.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Kang SH, Cho HT, Devi S, Zhang Z, Escuin
D, Liang Z, Mao H, Brat DJ, Olson JJ, Simons JW, et al: Antitumor
effect of 2-methoxyestradiol in a rat orthotopic brain tumor model.
Cancer Res. 66:11991–11997. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Chua YS, Chua YL and Hagen T: Structure
activity analysis of 2-methoxyestradiol analogues reveals targeting
of microtubules as the major mechanism of antiproliferative and
proapoptotic activity. Mol Cancer Ther. 9:224–235. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Maier HJ, Schmidt-Strassburger U, Huber
MA, Wiedemann EM, Beug H and Wirth T: NF-κB promotes
epithelial-mesenchymal transition, migration and invasion of
pancreatic carcinoma cells. Cancer Lett. 295:214–228. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Liu M, Sakamaki T, Casimiro MC, Willmarth
NE, Quong AA, Ju X, Ojeifo J, Jiao X, Yeow WS, Katiyar S, et al:
The canonical NF-κB pathway governs mammary tumorigenesis in
transgenic mice and tumor stem cell expansion. Cancer Res.
70:10464–10473. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Lin Y, Bai L, Chen W and Xu S: The NF-κB
activation pathways, emerging molecular targets for cancer
prevention and therapy. Expert Opin Ther Targets. 14:45–55. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Ray G, Dhar G, Van Veldhuizen PJ, Banerjee
S, Saxena NK, Sengupta K and Banerjee SK: Modulation of cell-cycle
regulatory signaling network by 2-methoxyestradiol in prostate
cancer cells is mediated through multiple signal transduction
pathways. Biochemistry. 45:3703–3713. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Siebert AE, Sanchez AL, Dinda S and
Moudgil VK: Effects of estrogen metabolite 2-methoxyestradiol on
tumor suppressor protein p53 and proliferation of breast cancer
cells. Syst Biol Reprod Med. 57:279–287. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Pasquier E, André N and Braguer D:
Targeting microtubules to inhibit angiogenesis and disrupt tumour
vasculature: Implications for cancer treatment. Curr Cancer Drug
Targets. 7:566–581. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Moeller BJ, Cao Y, Li CY and Dewhirst MW:
Radiation activates HIF-1 to regulate vascular radiosensitivity in
tumors: Role of reoxygenation, free radicals, and stress granules.
Cancer Cell. 5:429–441. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Walmsley SR, Print C, Farahi N,
Peyssonnaux C, Johnson RS, Cramer T, Sobolewski A, Condliffe AM,
Cowburn AS, Johnson N, et al: Hypoxia-induced neutrophil survival
is mediated by HIF-1α-dependent NF-κB activity. J Exp Med.
201:105–115. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Taylor CT: Interdependent roles for
hypoxia inducible factor and nuclear factor-κB in hypoxic
inflammation. J Physiol. 586:4055–4059. 2008. View Article : Google Scholar : PubMed/NCBI
|
