ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation

  • Authors:
    • Ueihuei Peng
    • Zhihao Wang
    • Sa Pei
    • Yunchao Ou
    • Pengchao Hu
    • Wanhong Liu
    • Jiquan Song
  • View Affiliations

  • Published online on: December 28, 2016     https://doi.org/10.3892/or.2016.5340
  • Pages: 1270-1276
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Abstract

BRAFV600E mutation is found in ~50% of melanoma patients and BRAFV600E kinase activity inhibitor, vemurafenib, has achieved a remarkable clinical response rate. However, most patients treated with vemurafenib eventually develop resistance. Overcoming primary and secondary resistance to selective BRAF inhibitors remains one of the most critically compelling challenges for these patients. HDAC6 has been shown to confer resistance to chemotherapy in several types of cancer. Few studies focused on the role of HDAC6 in vemurafenib resistance. Here we showed that overexpression of HDAC6 confers resistance to vemurafenib in BRAF-mutant A375 cells. ACY-1215, a selective HDAC6 inhibitor, inhibits the proliferation and induces the apoptosis of A375 cells. Moreover, ACY-1215 sensitizes A375 cells to vemurafenib induced cell proliferation inhibition and apoptosis induction, which occur partly through induction of endoplasmic reticulum (ER) stress and inactivation of extracellular signal-regulated kinase (ERK). Taken together, our results suggest that the inhibition of HDAC6 may be a promising strategy for the treatment of melanoma and overcoming resistance to vemurafenib.
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February-2017
Volume 37 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Peng U, Wang Z, Pei S, Ou Y, Hu P, Liu W and Song J: ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation. Oncol Rep 37: 1270-1276, 2017
APA
Peng, U., Wang, Z., Pei, S., Ou, Y., Hu, P., Liu, W., & Song, J. (2017). ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation. Oncology Reports, 37, 1270-1276. https://doi.org/10.3892/or.2016.5340
MLA
Peng, U., Wang, Z., Pei, S., Ou, Y., Hu, P., Liu, W., Song, J."ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation". Oncology Reports 37.2 (2017): 1270-1276.
Chicago
Peng, U., Wang, Z., Pei, S., Ou, Y., Hu, P., Liu, W., Song, J."ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation". Oncology Reports 37, no. 2 (2017): 1270-1276. https://doi.org/10.3892/or.2016.5340