Open Access

Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma

  • Authors:
    • Xiaobo Cui
    • Laixiao Song
    • Yunfei Bai
    • Yaping Wang
    • Boqian Wang
    • Wei Wang
  • View Affiliations

  • Published online on: December 29, 2016     https://doi.org/10.3892/or.2016.5341
  • Pages: 768-776
  • Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

IQGAP1 is a multifunctional scaffold protein involved in cell adhesion and cell migration. The abnormal expression of IQGAP1 widely exists in many cancers, but the combined biological roles of IQGAP1 and CDC42 in human glioma remain to be clarified. In this study, we investigated the associated expression level of IQGAP1, CDC42 and clinical significances in human glioma, as well as its biological functions in glioma progression. Our results revealed that IQGAP1 and CDC42 are frequently elevated in glioma tissues compared with their noncancerous counterparts, and a high expression of IQGAP1 and CDC42 correlates with tumor grades and poor overall survival of glioma patients. Moreover, the overexpression of IQGAP1 improves cell proliferation and migration ability of human glioma cells, whereas the knockdown of IQGAP1 by siRNA reduces cell growth and cell migration in vitro. These results suggest that IQGAP1, CDC42 and their interactions play important roles in human glioma carcinogenesis and progression.
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February-2017
Volume 37 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Cui X, Song L, Bai Y, Wang Y, Wang B and Wang W: Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma. Oncol Rep 37: 768-776, 2017
APA
Cui, X., Song, L., Bai, Y., Wang, Y., Wang, B., & Wang, W. (2017). Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma. Oncology Reports, 37, 768-776. https://doi.org/10.3892/or.2016.5341
MLA
Cui, X., Song, L., Bai, Y., Wang, Y., Wang, B., Wang, W."Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma". Oncology Reports 37.2 (2017): 768-776.
Chicago
Cui, X., Song, L., Bai, Y., Wang, Y., Wang, B., Wang, W."Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma". Oncology Reports 37, no. 2 (2017): 768-776. https://doi.org/10.3892/or.2016.5341