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Article

Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway

  • Authors:
    • Feng Gao
    • Gang Deng
    • Wenbin Liu
    • Kechao Zhou
    • Ming Li
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasonography, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China, Department of Hepatobiliary and Pancreatic Surgery, The Third Xiangya Hospital of Central South University, Changsha, P.R. China, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China, Powder Metallurgy Research Institute of Central South University, Changsha, Hunan 410083, P.R. China, Changsha Stomatological Hospital, Changsha, Hunan 410004, P.R. China
  • Pages: 1203-1211
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    Published online on: January 3, 2017
       https://doi.org/10.3892/or.2017.5347
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Abstract

Resveratrol, one of the major polyphenols found in red wine, is suggested to have a role as a chemo­prevention or chemotherapy agent in various human cancer models. Herein, we report that resveratrol has a profound antitumor effect on human hepatocellular carcinoma (HCC) cells by down­regulation of the HGF-c-Met signaling pathway. Resveratrol inhibited anchorage-dependent and -independent growth of HCC cells in a dose-dependent manner. Short-term resveratrol exposure substantially decreased HGF-induced c-Met signaling pathway activation, and long-term exposure to resveratrol markedly inhibited c-Met expression on the cell membrane. Additionally, resveratrol suppressed HGF-induced cell invasion, and knockdown of c-Met decreased the sensitivity of HCC cells to resveratrol treatment. Finally, the antitumor activity of resveratrol was validated in xenograft model and resveratrol prominently restrained tumor growth in vivo. In summary, our results suggested that c-Met offers a candidate molecular target for hepatocellular carcinoma management.
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Copy and paste a formatted citation
Spandidos Publications style
Gao F, Deng G, Liu W, Zhou K and Li M: Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway. Oncol Rep 37: 1203-1211, 2017.
APA
Gao, F., Deng, G., Liu, W., Zhou, K., & Li, M. (2017). Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway. Oncology Reports, 37, 1203-1211. https://doi.org/10.3892/or.2017.5347
MLA
Gao, F., Deng, G., Liu, W., Zhou, K., Li, M."Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway". Oncology Reports 37.2 (2017): 1203-1211.
Chicago
Gao, F., Deng, G., Liu, W., Zhou, K., Li, M."Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway". Oncology Reports 37, no. 2 (2017): 1203-1211. https://doi.org/10.3892/or.2017.5347
Copy and paste a formatted citation
x
Spandidos Publications style
Gao F, Deng G, Liu W, Zhou K and Li M: Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway. Oncol Rep 37: 1203-1211, 2017.
APA
Gao, F., Deng, G., Liu, W., Zhou, K., & Li, M. (2017). Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway. Oncology Reports, 37, 1203-1211. https://doi.org/10.3892/or.2017.5347
MLA
Gao, F., Deng, G., Liu, W., Zhou, K., Li, M."Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway". Oncology Reports 37.2 (2017): 1203-1211.
Chicago
Gao, F., Deng, G., Liu, W., Zhou, K., Li, M."Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway". Oncology Reports 37, no. 2 (2017): 1203-1211. https://doi.org/10.3892/or.2017.5347
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