Open Access

Monoclonal antibody Zt/g4 targeting RON receptor tyrosine kinase enhances chemosensitivity of bladder cancer cells to Epirubicin by promoting G1/S arrest and apoptosis

  • Authors:
    • Jun-Feng Chen
    • Bi-Xia Yu
    • Rui Yu
    • Liang Ma
    • Xiu-Yi Lv
    • Yue Cheng
    • Qi Ma
  • View Affiliations

  • Published online on: January 5, 2017     https://doi.org/10.3892/or.2017.5356
  • Pages: 721-728
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epirubicin (EPI) is one of the most used intravesical chemotherapy agents after transurethral resection to non-muscle invasive bladder tumors (NMIBC) to prevent cancer recurrence and progression. However, even after resection of bladder tumors and intravesical chemotherapy, half of them will recur and progress. RON is a membrane tyrosine kinase receptor usually overexpressed in bladder cancer cells and associated with poor pathological features. This study aims to investigate the effects of anti-RON monoclonal antibody Zt/g4 on the chemosensitivity of bladder cells to EPI. After Zt/g4 treatment, cell cytotoxicity was significantly increased and cell invasion was markedly suppressed in EPI-treated bladder cancer cells. Further investigation indicated that combing Zt/g4 with EPI promoted cell G1/S-phase arrest and apoptosis, which are the potential mechanisms that RON signaling inhibition enhances chemosensitivity of EPI. Thus, combing antibody-based RON targeted therapy enhances the therapeutic effects of intravesical chemotherapy, which provides new strategy for further improvement of NMIBC patient outcomes.
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February-2017
Volume 37 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Chen J, Yu B, Yu R, Ma L, Lv X, Cheng Y and Ma Q: Monoclonal antibody Zt/g4 targeting RON receptor tyrosine kinase enhances chemosensitivity of bladder cancer cells to Epirubicin by promoting G1/S arrest and apoptosis. Oncol Rep 37: 721-728, 2017
APA
Chen, J., Yu, B., Yu, R., Ma, L., Lv, X., Cheng, Y., & Ma, Q. (2017). Monoclonal antibody Zt/g4 targeting RON receptor tyrosine kinase enhances chemosensitivity of bladder cancer cells to Epirubicin by promoting G1/S arrest and apoptosis. Oncology Reports, 37, 721-728. https://doi.org/10.3892/or.2017.5356
MLA
Chen, J., Yu, B., Yu, R., Ma, L., Lv, X., Cheng, Y., Ma, Q."Monoclonal antibody Zt/g4 targeting RON receptor tyrosine kinase enhances chemosensitivity of bladder cancer cells to Epirubicin by promoting G1/S arrest and apoptosis". Oncology Reports 37.2 (2017): 721-728.
Chicago
Chen, J., Yu, B., Yu, R., Ma, L., Lv, X., Cheng, Y., Ma, Q."Monoclonal antibody Zt/g4 targeting RON receptor tyrosine kinase enhances chemosensitivity of bladder cancer cells to Epirubicin by promoting G1/S arrest and apoptosis". Oncology Reports 37, no. 2 (2017): 721-728. https://doi.org/10.3892/or.2017.5356