Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
March-2017 Volume 37 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2017 Volume 37 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Diets link metabolic syndrome and colorectal cancer development (Review)

  • Authors:
    • Jirakrit Saetang
    • Surasak Sangkhathat
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand, Tumor Biology Research Unit, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand
  • Pages: 1312-1320
    |
    Published online on: January 18, 2017
       https://doi.org/10.3892/or.2017.5385
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Diets have been believed to be an important factor in the development of metabolic syndrome and colorectal cancer (CRC). In recent years, many studies have shown an intimate relationship between mucosal immunity, metabolism and diets, which has led to a greater understanding of the pathophysiology of metabolic syndrome and CRC development. Although the precise effects of diets on oncogenesis have not been compl­etely elucidated, microbiota changes and inflammation are believed to be important factors that influence the development of CRC. Moreover, increased release of pro-inflammatory cytokines and alteration of adipokine levels have been observed in patients with colorectal adenoma and/or CRC, and these all have been considered as the important mechanisms that link diets to the development of metabolic syndrome and CRC. Importantly, a high-fat, low-fiber diet is associated with dysbiosis, and as the gut signature becomes more important in metabolic syndrome and CRC, an increased understanding of diets on bacterial activity in the pathogenesis of metabolic syndrome and CRC will lead to new preventive and therapeutic strategies.
View Figures

Figure 1

Figure 2

View References

1 

Balkau B, Deanfield JE, Després JP, Bassand JP, Fox KA, Smith SC Jr, Barter P, Tan CE, Van Gaal L, Wittchen HU, et al: International Day for the Evaluation of Abdominal Obesity (IDEA): a study of waist circumference, cardiovascular disease, and diabetes mellitus in 168,000 primary care patients in 63 countries. Circulation. 116:1942–1951. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Grundy SM: Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol. 28:629–636. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Prasad DS, Kabir Z, Dash AK and Das BC: Prevalence and risk factors for metabolic syndrome in Asian Indians: a community study from urban Eastern India. J Cardiovasc Dis Res. 3:204–211. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Gu D, Reynolds K, Wu X, Chen J, Duan X, Reynolds RF, Whelton PK and He J: InterASIA Collaborative Group: Prevalence of the metabolic syndrome and overweight among adults in China. Lancet. 365:1398–1405. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Reynolds K and He J: Epidemiology of the metabolic syndrome. Am J Med Sci. 330:273–279. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Wilson PW: Metabolic risk factors for coronary heart disease: current and future prospects. Curr Opin Cardiol. 14:176–185. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Miranda PJ, DeFronzo RA, Califf RM and Guyton JR: Metabolic syndrome: definition, pathophysiology, and mechanisms. Am Heart J. 149:33–45. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Dentali F, di Minno MN, Gianni M, di Minno G, Squizzato A and Ageno W: The role of the metabolic syndrome in patients with provoked venous thromboembolic events. Thromb Haemost. 109:759–761. 2013. View Article : Google Scholar : PubMed/NCBI

9 

van Rooy MJ, Duim W, Ehlers R, Buys AV and Pretorius E: Platelet hyperactivity and fibrin clot structure in transient ischemic attack individuals in the presence of metabolic syndrome: a microscopy and thromboelastography study. Cardiovasc Diabetol. 14:862015. View Article : Google Scholar : PubMed/NCBI

10 

Ebrahimi F and Christ-Crain M: Metabolic syndrome and hypogonadism - two peas in a pod. Swiss Med Wkly. 146:w142832016.PubMed/NCBI

11 

Uzunlulu M, Telci Caklili O and Oguz A: Association between metabolic syndrome and cancer. Ann Nutr Metab. 68:173–179. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Chen J, He X and Huang J: Diet effects in gut microbiome and obesity. J Food Sci. 79:R442–R451. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Festi D, Schiumerini R, Eusebi LH, Marasco G, Taddia M and Colecchia A: Gut microbiota and metabolic syndrome. World J Gastroenterol. 20:16079–16094. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Parekh PJ, Balart LA and Johnson DA: The Influence of the gut microbiome on obesity, metabolic syndrome and gastrointestinal disease. Clin Transl Gastroenterol. 6:e912015. View Article : Google Scholar : PubMed/NCBI

15 

Marchesi JR, Adams DH, Fava F, Hermes GD, Hirschfield GM, Hold G, Quraishi MN, Kinross J, Smidt H, Tuohy KM, et al: The gut microbiota and host health: a new clinical frontier. Gut. 65:330–339. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Pigrau M, Rodiño-Janeiro BK, Casado-Bedmar M, Lobo B, Vicario M, Santos J and Alonso-Cotoner C: The joint power of sex and stress to modulate brain-gut-microbiota axis and intestinal barrier homeostasis: implications for irritable bowel syndrome. Neurogastroenterol Motil. 28:463–486. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Aballay LR, Eynard AR, Díaz M, del P, Navarro A and Muñoz SE: Overweight and obesity: a review of their relationship to metabolic syndrome, cardiovascular disease, and cancer in South America. Nutr Rev. 71:168–179. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Welty FK, Alfaddagh A and Elajami TK: Targeting inflammation in metabolic syndrome. Transl Res. 167:257–280. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD and Gordon JI: Obesity alters gut microbial ecology. Proc Natl Acad Sci USA. 102:11070–11075. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Pischon T, Lahmann PH, Boeing H, Friedenreich C, Norat T, Tjønneland A, Halkjaer J, Overvad K, Clavel-Chapelon F, Boutron-Ruault MC, et al: Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 98:920–931. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Pelucchi C, Negri E, Talamini R, Levi F, Giacosa A, Crispo A, Bidoli E, Montella M, Franceschi S and La Vecchia C: Metabolic syndrome is associated with colorectal cancer in men. Eur J Cancer. 46:1866–1872. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Esposito K, Chiodini P, Colao A, Lenzi A and Giugliano D: Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care. 35:2402–2411. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Kyrou I, Randeva HS and Weickert MO: Clinical problems caused by obesity: Endotext (Internet). De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, Koch C, Korbonits M, McLachlan R, New M, et al: MDText.com, Inc.; South Dartmouth, MA, USA: 2000 https://www.endotext.orgApril 24–2014

24 

Knecht S, Ellger T and Levine JA: Obesity in neurobiology. Prog Neurobiol. 84:85–103. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Sheth RD: Metabolic concerns associated with antiepileptic medications. Neurology. 63 Suppl 4:S24–S29. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Broberger C: Brain regulation of food intake and appetite: molecules and networks. J Intern Med. 258:301–327. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Peters A, Schweiger U, Pellerin L, Hubold C, Oltmanns KM, Conrad M, Schultes B, Born J and Fehm HL: The selfish brain: competition for energy resources. Neurosci Biobehav Rev. 28:143–180. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Peters A, Pellerin L, Dallman MF, Oltmanns KM, Schweiger U, Born J and Fehm HL: Causes of obesity: looking beyond the hypothalamus. Prog Neurobiol. 81:61–88. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Woods SC, Stein LJ, McKay LD and D Jr Porte: Suppression of food intake by intravenous nutrients and insulin in the baboon. Am J Physiol. 247:R393–R401. 1984.PubMed/NCBI

30 

Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E and Flier JS: Role of leptin in the neuroendocrine response to fasting. Nature. 382:250–252. 1996. View Article : Google Scholar : PubMed/NCBI

31 

Kreier F, Kap YS, Mettenleiter TC, van Heijningen C, van der Vliet J, Kalsbeek A, Sauerwein HP, Fliers E, Romijn JA and Buijs RM: Tracing from fat tissue, liver, and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes. Endocrinology. 147:1140–1147. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, et al: Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science. 312:1656–1659. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, et al: Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 49:191–203. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Brown FD, Fessler RG, Rachlin JR and Mullan S: Changes in food intake with electrical stimulation of the ventromedial hypothalamus in dogs. J Neurosurg. 60:1253–1257. 1984. View Article : Google Scholar : PubMed/NCBI

35 

Choi S, Sparks R, Clay M and Dallman MF: Rats with hypothalamic obesity are insensitive to central leptin injections. Endocrinology. 140:4426–4433. 1999. View Article : Google Scholar

36 

Grundmann SJ, Pankey EA, Cook MM, Wood AL, Rollins BL and King BM: Combination unilateral amygdaloid and ventromedial hypothalamic lesions: evidence for a feeding pathway. Am J Physiol Regul Integr Comp Physiol. 288:R702–R707. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Majdic G, Young M, Gomez-Sanchez E, Anderson P, Szczepaniak LS, Dobbins RL, McGarry JD and Parker KL: Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity. Endocrinology. 143:607–614. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Bingham NC, Anderson KK, Reuter AL, Stallings NR and Parker KL: Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology. 149:2138–2148. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Coleman DL: Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia. 14:141–148. 1978. View Article : Google Scholar : PubMed/NCBI

40 

Clément K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, et al: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 392:398–401. 1998. View Article : Google Scholar : PubMed/NCBI

41 

Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, et al: Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 387:903–908. 1997. View Article : Google Scholar : PubMed/NCBI

42 

Kaszubska W, Falls HD, Schaefer VG, Haasch D, Frost L, Hessler P, Kroeger PE, White DW, Jirousek MR and Trevillyan JM: Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line. Mol Cell Endocrinol. 195:109–118. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Egawa K, Maegawa H, Shimizu S, Morino K, Nishio Y, Bryer-Ash M, Cheung AT, Kolls JK, Kikkawa R and Kashiwagi A: Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells. J Biol Chem. 276:10207–10211. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG and Kahn BB: Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med. 12:917–924. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Cox JE and Powley TL: Prior vagotomy blocks VMH obesity in pair-fed rats. Am J Physiol. 240:E573–E583. 1981.PubMed/NCBI

46 

Brüning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Müller-Wieland D and Kahn CR: Role of brain insulin receptor in control of body weight and reproduction. Science. 289:2122–2125. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Volkow ND and Wise RA: How can drug addiction help us understand obesity? Nat Neurosci. 8:555–560. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Wallenius V, Wallenius K, Ahrén B, Rudling M, Carlsten H, Dickson SL, Ohlsson C and Jansson JO: Interleukin-6-deficient mice develop mature-onset obesity. Nat Med. 8:75–79. 2002. View Article : Google Scholar : PubMed/NCBI

49 

King BM: Amygdaloid lesion-induced obesity: relation to sexual behavior, olfaction, and the ventromedial hypothalamus. Am J Physiol Regul Integr Comp Physiol. 291:R1201–R1214. 2006. View Article : Google Scholar : PubMed/NCBI

50 

Peters A: The selfish brain: competition for energy resources. Am J Hum Biol. 23:29–34. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Peters A and McEwen BS: Stress habituation, body shape and cardiovascular mortality. Neurosci Biobehav Rev. 56:139–150. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Hitze B, Hubold C, van Dyken R, Schlichting K, Lehnert H, Entringer S and Peters A: How the selfish brain organizes its supply and demand. Front Neuroenergetics. 2:72010.PubMed/NCBI

53 

Kubera B, Hubold C, Zug S, Wischnath H, Wilhelm I, Hallschmid M, Entringer S, Langemann D and Peters A: The brain's supply and demand in obesity. Front Neuroenergetics. 4:42012. View Article : Google Scholar : PubMed/NCBI

54 

Khodabandehloo H, Gorgani-Firuzjaee S, Panahi G and Meshkani R: Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction. Transl Res. 167:228–256. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Cai D and Liu T: Hypothalamic inflammation: a double-edged sword to nutritional diseases. Ann N Y Acad Sci. 1243:E1–E39. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Cai D and Liu T: Inflammatory cause of metabolic syndrome via brain stress and NF-κB. Aging (Albany, NY). 4:98–115. 2012. View Article : Google Scholar

57 

Gregor MF and Hotamisligil GS: Inflammatory mechanisms in obesity. Annu Rev Immunol. 29:415–445. 2011. View Article : Google Scholar : PubMed/NCBI

58 

Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL and Ferrante AW Jr: Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 112:1796–1808. 2003. View Article : Google Scholar : PubMed/NCBI

59 

Lee BC and Lee J: Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta. 1842:446–462. 2014. View Article : Google Scholar : PubMed/NCBI

60 

Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C and Exley MA: Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity. 37:574–587. 2012. View Article : Google Scholar : PubMed/NCBI

61 

Yoshimura A, Ohnishi S, Orito C, Kawahara Y, Takasaki H, Takeda H, Sakamoto N and Hashino S: Association of peripheral total and differential leukocyte counts with obesity-related complications in young adults. Obes Facts. 8:1–16. 2015. View Article : Google Scholar : PubMed/NCBI

62 

Krinninger P, Ensenauer R, Ehlers K, Rauh K, Stoll J, Krauss-Etschmann S, Hauner H and Laumen H: Peripheral monocytes of obese women display increased chemokine receptor expression and migration capacity. J Clin Endocrinol Metab. 99:2500–2509. 2014. View Article : Google Scholar : PubMed/NCBI

63 

Poitou C, Dalmas E, Renovato M, Benhamo V, Hajduch F, Abdennour M, Kahn JF, Veyrie N, Rizkalla S, Fridman WH, et al: CD14dimCD16+ and CD14+CD16+ monocytes in obesity and during weight loss: relationships with fat mass and subclinical atherosclerosis. Arterioscler Thromb Vasc Biol. 31:2322–2330. 2011. View Article : Google Scholar : PubMed/NCBI

64 

Christiansen T, Richelsen B and Bruun JM: Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Int J Obes. 29:146–150. 2005. View Article : Google Scholar

65 

Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K, et al: MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest. 116:1494–1505. 2006. View Article : Google Scholar : PubMed/NCBI

66 

Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel RL and Ferrante AW Jr: CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest. 116:115–124. 2006. View Article : Google Scholar : PubMed/NCBI

67 

Bolus WR, Gutierrez DA, Kennedy AJ, Anderson-Baucum EK and Hasty AH: CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue. J Leukoc Biol. 98:467–477. 2015. View Article : Google Scholar : PubMed/NCBI

68 

Kim D, Kim J, Yoon JH, Ghim J, Yea K, Song P, Park S, Lee A, Hong CP, Jang MS, et al: CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice. Diabetologia. 57:1456–1465. 2014. View Article : Google Scholar : PubMed/NCBI

69 

Nara N, Nakayama Y, Okamoto S, Tamura H, Kiyono M, Muraoka M, Tanaka K, Taya C, Shitara H, Ishii R, et al: Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance. J Biol Chem. 282:30794–30803. 2007. View Article : Google Scholar : PubMed/NCBI

70 

Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, Takamura T, Yamamoto H, Miyamoto K, Ginsberg HN, et al: CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Diabetes. 61:1680–1690. 2012. View Article : Google Scholar : PubMed/NCBI

71 

Dalmas E, Clément K and Guerre-Millo M: Defining macrophage phenotype and function in adipose tissue. Trends Immunol. 32:307–314. 2011. View Article : Google Scholar : PubMed/NCBI

72 

Lumeng CN, Bodzin JL and Saltiel AR: Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 117:175–184. 2007. View Article : Google Scholar : PubMed/NCBI

73 

Kratz M, Coats BR, Hisert KB, Hagman D, Mutskov V, Peris E, Schoenfelt KQ, Kuzma JN, Larson I, Billing PS, et al: Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. Cell Metab. 20:614–625. 2014. View Article : Google Scholar : PubMed/NCBI

74 

Elgazar-Carmon V, Rudich A, Hadad N and Levy R: Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J Lipid Res. 49:1894–1903. 2008. View Article : Google Scholar : PubMed/NCBI

75 

Talukdar S, Oh DY, Bandyopadhyay G, Li D, Xu J, McNelis J, Lu M, Li P, Yan Q, Zhu Y, et al: Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med. 18:1407–1412. 2012. View Article : Google Scholar : PubMed/NCBI

76 

Xu X, Su S and Wang X, Barnes V, De Miguel C, Ownby D, Pollock J, Snieder H, Chen W and Wang X: Obesity is associated with more activated neutrophils in African American male youth. Int J Obes (Lond). 39:26–32. 2015.PubMed/NCBI

77 

Sell H, Habich C and Eckel J: Adaptive immunity in obesity and insulin resistance. Nat Rev Endocrinol. 8:709–716. 2012. View Article : Google Scholar : PubMed/NCBI

78 

Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, et al: Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 15:930–939. 2009. View Article : Google Scholar : PubMed/NCBI

79 

Strissel KJ, DeFuria J, Shaul ME, Bennett G, Greenberg AS and Obin MS: T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice. Obesity (Silver Spring). 18:1918–1925. 2010. View Article : Google Scholar : PubMed/NCBI

80 

Winer S, Paltser G, Chan Y, Tsui H, Engleman E, Winer D and Dosch HM: Obesity predisposes to Th17 bias. Eur J Immunol. 39:2629–2635. 2009. View Article : Google Scholar : PubMed/NCBI

81 

Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, et al: CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 15:914–920. 2009. View Article : Google Scholar : PubMed/NCBI

82 

Wu H, Ghosh S, Perrard XD, Feng L, Garcia GE, Perrard JL, Sweeney JF, Peterson LE, Chan L, Smith CW, et al: T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation. 115:1029–1038. 2007. View Article : Google Scholar : PubMed/NCBI

83 

Winer DA, Winer S, Shen L, Wadia PP, Yantha J, Paltser G, Tsui H, Wu P, Davidson MG, Alonso MN, et al: B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med. 17:610–617. 2011. View Article : Google Scholar : PubMed/NCBI

84 

Sun S, Ji Y, Kersten S and Qi L: Mechanisms of inflammatory responses in obese adipose tissue. Annu Rev Nutr. 32:261–286. 2012. View Article : Google Scholar : PubMed/NCBI

85 

Duffaut C, Galitzky J, Lafontan M and Bouloumié A: Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem Biophys Res Commun. 384:482–485. 2009. View Article : Google Scholar : PubMed/NCBI

86 

DeFuria J, Belkina AC, Jagannathan-Bogdan M, Snyder-Cappione J, Carr JD, Nersesova YR, Markham D, Strissel KJ, Watkins AA, Zhu M, et al: B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci USA. 110:5133–5138. 2013. View Article : Google Scholar : PubMed/NCBI

87 

Jagannathan M, McDonnell M, Liang Y, Hasturk H, Hetzel J, Rubin D, Kantarci A, Van Dyke TE, Ganley-Leal LM and Nikolajczyk BS: Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia. 53:1461–1471. 2010. View Article : Google Scholar : PubMed/NCBI

88 

van Exel E, Gussekloo J, De Craen AJM, Frölich M, Bootsma-Van Der Wiel A and Westendorp RGJ: Leiden 85 Plus Study: Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes: The Leiden 85-Plus Study. Diabetes. 51:1088–1092. 2002. View Article : Google Scholar : PubMed/NCBI

89 

Gomes AC, Bueno AA, de Souza RGM and Mota JF: Gut microbiota, probiotics and diabetes. Nutr J. 13:602014. View Article : Google Scholar : PubMed/NCBI

90 

Bajzer M and Seeley RJ: Physiology: obesity and gut flora. Nature. 444:1009–1010. 2006. View Article : Google Scholar : PubMed/NCBI

91 

Sekirov I, Russell SL, Antunes LCM and Finlay BB: Gut microbiota in health and disease. Physiol Rev. 90:859–904. 2010. View Article : Google Scholar : PubMed/NCBI

92 

David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, et al: Diet rapidly and reproducibly alters the human gut microbiome. Nature. 505:559–563. 2014. View Article : Google Scholar : PubMed/NCBI

93 

Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, et al: A core gut microbiome in obese and lean twins. Nature. 457:480–484. 2009. View Article : Google Scholar : PubMed/NCBI

94 

Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, Blanchard C, Junt T, Nicod LP, Harris NL, et al: Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 20:159–166. 2014. View Article : Google Scholar : PubMed/NCBI

95 

Ley RE, Turnbaugh PJ, Klein S and Gordon JI: Microbial ecology: human gut microbes associated with obesity. Nature. 444:1022–1023. 2006. View Article : Google Scholar : PubMed/NCBI

96 

Schwiertz A, Taras D, Schäfer K, Beijer S, Bos NA, Donus C and Hardt PD: Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring). 18:190–195. 2010. View Article : Google Scholar : PubMed/NCBI

97 

Duncan SH, Lobley GE, Holtrop G, Ince J, Johnstone AM, Louis P and Flint HJ: Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes. 32:1720–1724. 2008. View Article : Google Scholar

98 

Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF and Gordon JI: The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA. 101:15718–15723. 2004. View Article : Google Scholar : PubMed/NCBI

99 

Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G, Almeida M, Arumugam M, Batto JM, Kennedy S, et al: MetaHIT consortium: Richness of human gut microbiome correlates with metabolic markers. Nature. 500:541–546. 2013. View Article : Google Scholar : PubMed/NCBI

100 

Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR, et al: Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 341:12412142013. View Article : Google Scholar : PubMed/NCBI

101 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

102 

Sears CL and Garrett WS: Microbes, microbiota, and colon cancer. Cell Host Microbe. 15:317–328. 2014. View Article : Google Scholar : PubMed/NCBI

103 

Center MM, Jemal A and Ward E: International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev. 18:1688–1694. 2009. View Article : Google Scholar : PubMed/NCBI

104 

Center MM, Jemal A, Smith RA and Ward E: Worldwide variations in colorectal cancer. CA Cancer J Clin. 59:366–378. 2009. View Article : Google Scholar : PubMed/NCBI

105 

Duncan SH, Belenguer A, Holtrop G, Johnstone AM, Flint HJ and Lobley GE: Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl Environ Microbiol. 73:1073–1078. 2007. View Article : Google Scholar : PubMed/NCBI

106 

Keku TO, Dulal S, Deveaux A, Jovov B and Han X: The gastrointestinal microbiota and colorectal cancer. Am J Physiol Gastrointest Liver Physiol. 308:G351–G363. 2015. View Article : Google Scholar : PubMed/NCBI

107 

Medzhitov R: Origin and physiological roles of inflammation. Nature. 454:428–435. 2008. View Article : Google Scholar : PubMed/NCBI

108 

Nyangale EP, Mottram DS and Gibson GR: Gut microbial activity, implications for health and disease: the potential role of metabolite analysis. J Proteome Res. 11:5573–5585. 2012. View Article : Google Scholar : PubMed/NCBI

109 

Greer JB and O'Keefe SJ: Microbial induction of immunity, inflammation, and cancer. Front Physiol. 1:1682011. View Article : Google Scholar : PubMed/NCBI

110 

Módis K, Coletta C, Erdélyi K, Papapetropoulos A and Szabo C: Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics. FASEB J. 27:601–611. 2013. View Article : Google Scholar : PubMed/NCBI

111 

Nistal E, Fernández-Fernández N, Vivas S and Olcoz JL: Factors determining colorectal cancer: the role of the intestinal microbiota. Front Oncol. 5:2202015. View Article : Google Scholar : PubMed/NCBI

112 

Dvorak K, Payne CM, Chavarria M, Ramsey L, Dvorakova B, Bernstein H, Holubec H, Sampliner RE, Guy N, Condon A, et al: Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett's oesophagus. Gut. 56:763–771. 2007. View Article : Google Scholar : PubMed/NCBI

113 

Gill CI and Rowland IR: Diet and cancer: assessing the risk. Br J Nutr. 88 Suppl 1:S73–S87. 2002. View Article : Google Scholar : PubMed/NCBI

114 

Sobko T, Huang L, Midtvedt T, Norin E, Gustafsson LE, Norman M, Jansson EA and Lundberg JO: Generation of NO by probiotic bacteria in the gastrointestinal tract. Free Radic Biol Med. 41:985–991. 2006. View Article : Google Scholar : PubMed/NCBI

115 

Sobko T, Reinders CI, Jansson E, Norin E, Midtvedt T and Lundberg JO: Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite. Nitric Oxide. 13:272–278. 2005. View Article : Google Scholar : PubMed/NCBI

116 

Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, et al: Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 491:254–258. 2012.PubMed/NCBI

117 

Sprong RC, Schonewille AJ and van der Meer R: Dietary cheese whey protein protects rats against mild dextran sulfate sodium-induced colitis: role of mucin and microbiota. J Dairy Sci. 93:1364–1371. 2010. View Article : Google Scholar : PubMed/NCBI

118 

Hursting SD, Digiovanni J, Dannenberg AJ, Azrad M, Leroith D, Demark-Wahnefried W, Kakarala M, Brodie A and Berger NA: Obesity, energy balance, and cancer: new opportunities for prevention. Cancer Prev Res (Phila). 5:1260–1272. 2012. View Article : Google Scholar : PubMed/NCBI

119 

Tilg H and Moschen AR: Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 6:772–783. 2006. View Article : Google Scholar : PubMed/NCBI

120 

Bardou M, Barkun AN and Martel M: Obesity and colorectal cancer. Gut. 62:933–947. 2013. View Article : Google Scholar : PubMed/NCBI

121 

Barb D, Williams CJ, Neuwirth AK and Mantzoros CS: Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr. 86:s858–s866. 2007.PubMed/NCBI

122 

Scherer PE, Williams S, Fogliano M, Baldini G and Lodish HF: A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 270:26746–26749. 1995. View Article : Google Scholar : PubMed/NCBI

123 

Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K and Tobe K: Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 116:1784–1792. 2006. View Article : Google Scholar : PubMed/NCBI

124 

Nakashima R, Kamei N, Yamane K, Nakanishi S, Nakashima A and Kohno N: Decreased total and high molecular weight adiponectin are independent risk factors for the development of type 2 diabetes in Japanese-Americans. J Clin Endocrinol Metab. 91:3873–3877. 2006. View Article : Google Scholar : PubMed/NCBI

125 

Renehan AG, Zwahlen M and Egger M: Adiposity and cancer risk: new mechanistic insights from epidemiology. Nat Rev Cancer. 15:484–498. 2015. View Article : Google Scholar : PubMed/NCBI

126 

Guffey CR, Fan D, Singh UP and Murphy EA: Linking obesity to colorectal cancer: recent insights into plausible biological mechanisms. Curr Opin Clin Nutr Metab Care. 16:595–600. 2013. View Article : Google Scholar : PubMed/NCBI

127 

Hillenbrand A, Fassler J, Huber N, Xu P, Henne-Bruns D, Templin M, Schrezenmeier H, Wolf AM and Knippschild U: Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls. BMC Cancer. 12:5452012. View Article : Google Scholar : PubMed/NCBI

128 

Xu XT, Xu Q, Tong JL, Zhu MM, Huang ML, Ran ZH and Xiao SD: Meta-analysis: circulating adiponectin levels and risk of colorectal cancer and adenoma. J Dig Dis. 12:234–244. 2011. View Article : Google Scholar : PubMed/NCBI

129 

An W, Bai Y, Deng SX, Gao J, Ben QW, Cai QC, Zhang HG and Li ZS: Adiponectin levels in patients with colorectal cancer and adenoma: a meta-analysis. Eur J Cancer Prev. 21:126–133. 2012. View Article : Google Scholar : PubMed/NCBI

130 

Gulcelik MA, Colakoglu K, Dincer H, Dogan L, Yenidogan E and Gulcelik NE: Associations between adiponectin and two different cancers: breast and colon. Asian Pac J Cancer Prev. 13:395–398. 2012. View Article : Google Scholar : PubMed/NCBI

131 

Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, Inamori M, Nakajima N, Watanabe M, Kubota N, et al: Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut. 57:1531–1538. 2008. View Article : Google Scholar : PubMed/NCBI

132 

Sugiyama M, Takahashi H, Hosono K, Endo H, Kato S, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Wada K, et al: Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway. Int J Oncol. 34:339–344. 2009.PubMed/NCBI

133 

Moon HS, Liu X, Nagel JM, Chamberland JP, Diakopoulos KN, Brinkoetter MT, Hatziapostolou M, Wu Y, Robson SC, Iliopoulos D, et al: Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. Gut. 62:561–570. 2013. View Article : Google Scholar : PubMed/NCBI

134 

Sun Y and Lodish HF: Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration. PLoS One. 5:e119872010. View Article : Google Scholar : PubMed/NCBI

135 

Vansaun MN: Molecular pathways: adiponectin and leptin signaling in cancer. Clin Cancer Res. 19:1926–1932. 2013. View Article : Google Scholar : PubMed/NCBI

136 

Friedman JM and Halaas JL: Leptin and the regulation of body weight in mammals. Nature. 395:763–770. 1998. View Article : Google Scholar : PubMed/NCBI

137 

Ryan AS, Berman DM, Nicklas BJ, Sinha M, Gingerich RL, Meneilly GS, Egan JM and Elahi D: Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. Diabetes Care. 26:2383–2388. 2003. View Article : Google Scholar : PubMed/NCBI

138 

Tamakoshi K, Toyoshima H, Wakai K, Kojima M, Suzuki K, Watanabe Y, Hayakawa N, Yatsuya H, Kondo T, Tokudome S, et al: Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan. Oncology. 68:454–461. 2005. View Article : Google Scholar : PubMed/NCBI

139 

Delort L, Rossary A, Farges MC, Vasson MP and Caldefie-Chézet F: Leptin, adipocytes and breast cancer: focus on inflammation and anti-tumor immunity. Life Sci. 140:37–48. 2015. View Article : Google Scholar : PubMed/NCBI

140 

Wang D, Chen J, Chen H, Duan Z, Xu Q, Wei M, Wang L and Zhong M: Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway. J Biosci. 37:91–101. 2012. View Article : Google Scholar : PubMed/NCBI

141 

Padidar S, Farquharson AJ, Williams LM, Kearney R, Arthur JR and Drew JE: High-fat diet alters gene expression in the liver and colon: links to increased development of aberrant crypt foci. Dig Dis Sci. 57:1866–1874. 2012. View Article : Google Scholar : PubMed/NCBI

142 

Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H, et al: Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis. Gut. 60:1363–1371. 2011. View Article : Google Scholar : PubMed/NCBI

143 

Braun S, Bitton-Worms K and LeRoith D: The link between the metabolic syndrome and cancer. Int J Biol Sci. 7:1003–1015. 2011. View Article : Google Scholar : PubMed/NCBI

144 

Grossmann ME, Mizuno NK, Bonorden MJL, Ray A, Sokolchik I, Narasimhan ML and Cleary MP: Role of the adiponectin leptin ratio in prostate cancer. Oncol Res. 18:269–277. 2009. View Article : Google Scholar : PubMed/NCBI

145 

Sharma D, Wang J, Fu PP, Sharma S, Nagalingam A, Mells J, Handy J, Page AJ, Cohen C, Anania FA, et al: Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis. Hepatology. 52:1713–1722. 2010. View Article : Google Scholar : PubMed/NCBI

146 

Liu Z, Brooks RS, Ciappio ED, Kim SJ, Crott JW, Bennett G, Greenberg AS and Mason JB: Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer. J Nutr Biochem. 23:1207–1213. 2012. View Article : Google Scholar : PubMed/NCBI

147 

Dolcet X, Llobet D, Pallares J and Matias-Guiu X: NF-κB in development and progression of human cancer. Virchows Arch. 446:475–482. 2005. View Article : Google Scholar : PubMed/NCBI

148 

Pais R, Silaghi H, Silaghi AC, Rusu ML and Dumitrascu DL: Metabolic syndrome and risk of subsequent colorectal cancer. World J Gastroenterol. 15:5141–5148. 2009. View Article : Google Scholar : PubMed/NCBI

149 

Clayton PE, Banerjee I, Murray PG and Renehan AG: Growth hormone, the insulin-like growth factor axis, insulin and cancer risk. Nat Rev Endocrinol. 7:11–24. 2011. View Article : Google Scholar : PubMed/NCBI

150 

Singh P and Rubin N: Insulinlike growth factors and binding proteins in colon cancer. Gastroenterology. 105:1218–1237. 1993. View Article : Google Scholar : PubMed/NCBI

151 

Giovannucci E: Nutrition, insulin, insulin-like growth factors and cancer. Horm Metab Res. 35:694–704. 2003. View Article : Google Scholar : PubMed/NCBI

152 

Komninou D, Ayonote A, Richie JP Jr and Rigas B: Insulin resistance and its contribution to colon carcinogenesis. Exp Biol Med (Maywood). 228:396–405. 2003.PubMed/NCBI

153 

Hart LS, Dolloff NG, Dicker DT, Koumenis C, Christensen JG, Grimberg A and El-Deiry WS: Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab. Cell Cycle. 10:2331–2338. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Saetang J and Sangkhathat S: Diets link metabolic syndrome and colorectal cancer development (Review). Oncol Rep 37: 1312-1320, 2017.
APA
Saetang, J., & Sangkhathat, S. (2017). Diets link metabolic syndrome and colorectal cancer development (Review). Oncology Reports, 37, 1312-1320. https://doi.org/10.3892/or.2017.5385
MLA
Saetang, J., Sangkhathat, S."Diets link metabolic syndrome and colorectal cancer development (Review)". Oncology Reports 37.3 (2017): 1312-1320.
Chicago
Saetang, J., Sangkhathat, S."Diets link metabolic syndrome and colorectal cancer development (Review)". Oncology Reports 37, no. 3 (2017): 1312-1320. https://doi.org/10.3892/or.2017.5385
Copy and paste a formatted citation
x
Spandidos Publications style
Saetang J and Sangkhathat S: Diets link metabolic syndrome and colorectal cancer development (Review). Oncol Rep 37: 1312-1320, 2017.
APA
Saetang, J., & Sangkhathat, S. (2017). Diets link metabolic syndrome and colorectal cancer development (Review). Oncology Reports, 37, 1312-1320. https://doi.org/10.3892/or.2017.5385
MLA
Saetang, J., Sangkhathat, S."Diets link metabolic syndrome and colorectal cancer development (Review)". Oncology Reports 37.3 (2017): 1312-1320.
Chicago
Saetang, J., Sangkhathat, S."Diets link metabolic syndrome and colorectal cancer development (Review)". Oncology Reports 37, no. 3 (2017): 1312-1320. https://doi.org/10.3892/or.2017.5385
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team