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Article

Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway

  • Authors:
    • Zhihong Liu
    • You Lu
    • Yingmin Xiao
    • Yipin Lu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China, Department of Pediatrics, West China Second University Hospital, Chengdu, Sichuan, P.R. China, Department of Urology of Sichuan Tumor Hospital, Chengdu, Sichuan, P.R. China
  • Pages: 1437-1444
    |
    Published online on: January 24, 2017
       https://doi.org/10.3892/or.2017.5402
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Abstract

In the present study, we investigated whether the upregulation of miR-21 expression is a predictor of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma (RCC). It was found that the expression of miR-21 not only had a significant effect on the clinicopathological features and survival in patients with RCC, but also exerted an important influence on the occurrence rate of RCC. In addition, miR-21 expression was lower in the human kidney HRPTEpiC cell line than that noted in RCC A-498 cells. Meanwhile, the overexpression of miR-21 not only increased cell proliferation, inhibited apoptosis and reduced caspase-3 activity in the A-498 cells, but also suppressed p53, CDKN1A p21, cyclin E2 and Bax protein expression in the A-498 cells. In contrary, the downregulation of miR-21 expression promoted the protein expression of p53, CDKN1A p21 and cyclin E2, and decreased Bax protein expression and caspase-3 activity in the A-498 cells. Our data indicate a clear correlation between miR-21 expression and clinicopathological features and poor prognosis in patients with RCC through the p53/p21-cyclin E2-Bax/caspase-3 signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Lu Y, Xiao Y and Lu Y: Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway. Oncol Rep 37: 1437-1444, 2017.
APA
Liu, Z., Lu, Y., Xiao, Y., & Lu, Y. (2017). Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway. Oncology Reports, 37, 1437-1444. https://doi.org/10.3892/or.2017.5402
MLA
Liu, Z., Lu, Y., Xiao, Y., Lu, Y."Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway". Oncology Reports 37.3 (2017): 1437-1444.
Chicago
Liu, Z., Lu, Y., Xiao, Y., Lu, Y."Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway". Oncology Reports 37, no. 3 (2017): 1437-1444. https://doi.org/10.3892/or.2017.5402
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Lu Y, Xiao Y and Lu Y: Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway. Oncol Rep 37: 1437-1444, 2017.
APA
Liu, Z., Lu, Y., Xiao, Y., & Lu, Y. (2017). Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway. Oncology Reports, 37, 1437-1444. https://doi.org/10.3892/or.2017.5402
MLA
Liu, Z., Lu, Y., Xiao, Y., Lu, Y."Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway". Oncology Reports 37.3 (2017): 1437-1444.
Chicago
Liu, Z., Lu, Y., Xiao, Y., Lu, Y."Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway". Oncology Reports 37, no. 3 (2017): 1437-1444. https://doi.org/10.3892/or.2017.5402
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