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Article Open Access

Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1

  • Authors:
    • Jiao Yu
    • Xiaoxia Wang
    • Yuhua Li
    • Bin Tang
  • View Affiliations / Copyright

    Affiliations: Linyi Hospital of Traditional Chinese Medicine, Linyi, Shandong 276000, P.R. China, Linyi Tumor Hospital, Linyi, Shandong 276000, P.R. China, Lanzhou Hengdao Chinese Medicine Institute, Lanzhou, Shandong 730000, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1394-1400
    |
    Published online on: January 30, 2017
       https://doi.org/10.3892/or.2017.5408
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Abstract

Tanshinone IIA (TSN) exhibits a variety of anticancer effects. However, whether it inhibits gastric cancer (GC) cell proliferation and migration and the mechanism remain unclear. In the present study, different concentrations of TSN were co-incubated with SGC-7901 cells. The pcDNA-FOXM1 or FOXM1-siRNA plasmid was transfected into cells before treatment with 5 µg/l TSN. The proliferation and migration abilities of the SGC-7901 cells were tested by MTT and wound healing assays. Western blotting was used to investigate the expression levels of P21, Ki-67, PCNA, MMP-2, MMP-9 and FOXM1. We found that compared with the control, the proliferation and migration abilities of the SGC-7901 cells were decreased after incubation with different concentrations of TSN in a dose-dependent manner (p<0.01). Moreover, the expression levels of Ki-67, PCAN, MMP-2, MMP-9 and FOXM1 were decreased, and P21 was increased in the TSN-treated SGC-7901 cells (p<0.01). In addition, downregulation of FOXM1 by FOXM1-siRNA had the same effect as TSN on SGC-7901 cells, and overexpression of FOXM1 partly abrogated TSN-mediated inhibition of SGC-7901 cell proliferation and migration. These results suggested that TSN inhibits SGC-7901 cell proliferation and migration by downregulation of FOXM1.
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Copy and paste a formatted citation
Spandidos Publications style
Yu J, Wang X, Li Y and Tang B: Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1. Oncol Rep 37: 1394-1400, 2017.
APA
Yu, J., Wang, X., Li, Y., & Tang, B. (2017). Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1. Oncology Reports, 37, 1394-1400. https://doi.org/10.3892/or.2017.5408
MLA
Yu, J., Wang, X., Li, Y., Tang, B."Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1". Oncology Reports 37.3 (2017): 1394-1400.
Chicago
Yu, J., Wang, X., Li, Y., Tang, B."Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1". Oncology Reports 37, no. 3 (2017): 1394-1400. https://doi.org/10.3892/or.2017.5408
Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Wang X, Li Y and Tang B: Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1. Oncol Rep 37: 1394-1400, 2017.
APA
Yu, J., Wang, X., Li, Y., & Tang, B. (2017). Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1. Oncology Reports, 37, 1394-1400. https://doi.org/10.3892/or.2017.5408
MLA
Yu, J., Wang, X., Li, Y., Tang, B."Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1". Oncology Reports 37.3 (2017): 1394-1400.
Chicago
Yu, J., Wang, X., Li, Y., Tang, B."Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1". Oncology Reports 37, no. 3 (2017): 1394-1400. https://doi.org/10.3892/or.2017.5408
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