Oncol Rep 35: [Related article:] 2576-2582, 2016; DOI:
10.3892/or.2016.4681
Following the publication of this article, we
realize that there were some errors in the manuscript.
Details of the experiments describing the gene
silencing of RUNX3 with small interfering RNA (siRNA) were
erroneously included in this paper, and all references to siRNA
should have been deleted from the manuscript prior to
publication.
In the subsection entitled ‘Cell lines and cell
culture’ on page 2577, the left-hand column, the text should
have indicated that the human HCC cell lines Hep3B and Huh7 were
obtained from the American Type Culture Collection (ATCC; Manassas,
VA, USA), whereas HLF cells were obtained from the Japanese Cancer
Resources Bank (Tokyo, Japan).
Lastly, an error was made in describing the
calculation of the IC50 values, which did not correlate
with the data shown in Fig. 2. Therefore, the subsection entitled
‘Ectopic RUNX3 protein expression suppresses cell growth…’
should have been entitled ‘Ectopic RUNX3 protein expression
increases 5-FU and CDDP sensitivity’, and the text herein
should have read as follows:
We analyzed the effects of RUNX3 on chemosensitivity
in the RUNX3- or CAT (mock)-transfected Hep3B and Huh7 cells. RUNX3
expression enhanced 5-FU sensitivity in both cell lines; the cell
viability with 5-FU (100 nM) decreased from 66.3±4.6 to 34.3±5.0%,
and from 71.0±4.7% to 27.0±5.5% in the Hep3B and Huh7 cells,
respectively (Fig. 2A). RUNX3 expression also enhanced CDDP
sensitivity in both cell lines; the cell viability with CDDP (100
nM) decreased from 58.7±2.6% to 25.7±4.9%, and from 67.7±4.1% to
25.7±7.5% in the Hep3B and Huh7 cells, respectively (Fig. 2B).
We sincerely apologize for these errors and
oversights, which have not affected any of the overall conclusions
reported in the study, and regret any inconvenience they may have
caused.
