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Review

Radiological biomarkers for assessing response to locoregional therapies in hepatocellular carcinoma: From morphological to functional imaging (Review)

  • Authors:
    • Xiao-Dan Ye
    • Zuguo Yuan
    • Jian Zhang
    • Zheng Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200030, P.R. China, Radiation Oncology Center, The 1st Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China, Department of Nuclear Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R. China, Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China
  • Pages: 1337-1346
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    Published online on: February 3, 2017
       https://doi.org/10.3892/or.2017.5420
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Abstract

Many hepatocellular carcinoma (HCC) patients do not qualify for curative surgical intervention and are instead treated with locoregional therapies (LRTs) including ablative and endovascular therapies. Assessment of imaging response is essential in the management of HCC for determining efficacy of therapy and as a surrogate marker for improved survival. The established morphological image biomarkers for tumor burden measurement continue to be applied, as size measurement can easily be used in clinical practice. However, in the setting of liver-directed LRTs for HCC, simple tumor morphological changes can be less informative and usually appear later than biologic changes. Functional imaging (such as perfusion and diffusion imaging, PET-CT/MR and MR spectroscopy) has the potential to be a promising technique for assessment of HCC response to LRTs. Although promising, none of these functional imaging biomarkers have gone through all the required steps of standardization and validation and established accepted criteria for clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Ye X, Yuan Z, Zhang J and Yuan Z: Radiological biomarkers for assessing response to locoregional therapies in hepatocellular carcinoma: From morphological to functional imaging (Review). Oncol Rep 37: 1337-1346, 2017.
APA
Ye, X., Yuan, Z., Zhang, J., & Yuan, Z. (2017). Radiological biomarkers for assessing response to locoregional therapies in hepatocellular carcinoma: From morphological to functional imaging (Review). Oncology Reports, 37, 1337-1346. https://doi.org/10.3892/or.2017.5420
MLA
Ye, X., Yuan, Z., Zhang, J., Yuan, Z."Radiological biomarkers for assessing response to locoregional therapies in hepatocellular carcinoma: From morphological to functional imaging (Review)". Oncology Reports 37.3 (2017): 1337-1346.
Chicago
Ye, X., Yuan, Z., Zhang, J., Yuan, Z."Radiological biomarkers for assessing response to locoregional therapies in hepatocellular carcinoma: From morphological to functional imaging (Review)". Oncology Reports 37, no. 3 (2017): 1337-1346. https://doi.org/10.3892/or.2017.5420
Copy and paste a formatted citation
x
Spandidos Publications style
Ye X, Yuan Z, Zhang J and Yuan Z: Radiological biomarkers for assessing response to locoregional therapies in hepatocellular carcinoma: From morphological to functional imaging (Review). Oncol Rep 37: 1337-1346, 2017.
APA
Ye, X., Yuan, Z., Zhang, J., & Yuan, Z. (2017). Radiological biomarkers for assessing response to locoregional therapies in hepatocellular carcinoma: From morphological to functional imaging (Review). Oncology Reports, 37, 1337-1346. https://doi.org/10.3892/or.2017.5420
MLA
Ye, X., Yuan, Z., Zhang, J., Yuan, Z."Radiological biomarkers for assessing response to locoregional therapies in hepatocellular carcinoma: From morphological to functional imaging (Review)". Oncology Reports 37.3 (2017): 1337-1346.
Chicago
Ye, X., Yuan, Z., Zhang, J., Yuan, Z."Radiological biomarkers for assessing response to locoregional therapies in hepatocellular carcinoma: From morphological to functional imaging (Review)". Oncology Reports 37, no. 3 (2017): 1337-1346. https://doi.org/10.3892/or.2017.5420
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