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Article

miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma

  • Authors:
    • Jianping Liu
    • Zheng Su
    • Yunjie Zeng
    • Huayao Zhang
    • Shanglin Yang
    • Gaojie Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hepato-Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China, Comprehensive Department, Sun Yat-sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China, Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China, Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China
  • Pages: 1445-1450
    |
    Published online on: February 7, 2017
       https://doi.org/10.3892/or.2017.5431
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Abstract

Evidence reveals that microRNAs (miRNAs) play essential roles in hepatocellular carcinoma (HCC) tumorigenesis. In the present study, we identified an essential role for miR-922 in the development of HCC. We found that miR-922 was significantly upregulated in HCC cells and clinical tissues. Gain and loss of function studies indicated that miR-922 significantly promoted HCC cell proliferation. We subsequently identified that cylindromatosis (CYLD) was a target gene of miR-922. Moreover, miR-922 decreased CYLD expression, subsequently upregulating the expression of c-Myc and cyclin D1, while downregulating p-Rb expression. Furthermore, knockdown of CYLD expression by siRNA partially counteracted the tumor suppressive effect of the inhibitor of miR‑922, miR‑922-in. Taken together, our findings indicate that miR-922 plays a key role in the promotion of HCC cell proliferation, and strongly suggest that exogenous miR-922 may have therapeutic value for treating HCC.
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View References

1 

El-Serag HB and Rudolph KL: Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Callegari E, Gramantieri L, Domenicali M, D'Abundo L, Sabbioni S and Negrini M: MicroRNAs in liver cancer: A model for investigating pathogenesis and novel therapeutic approaches. Cell Death Differ. 22:46–57. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Xie W, Qin W, Kang Y, Zhou Z and Qin A: MicroRNA-340 inhibits tumor cell proliferation and induces apoptosis in endometrial carcinoma cell line RL 95–2. Med Sci Monit. 22:1540–1546. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Zhang M, Zhuang Q and Cui L: MiR-194 inhibits cell proliferation and invasion via repression of RAP2B in bladder cancer. Biomed Pharmacother. 80:268–275. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Jin L, Li Y, Liu J, Yang S, Gui Y, Mao X, Nie G and Lai Y: Tumor suppressor miR-149-5p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma. Mol Med Rep. 13:5386–5392. 2016.PubMed/NCBI

6 

Wang N, Wang Q, Shen D, Sun X, Cao X and Wu D: Downregulation of microRNA-122 promotes proliferation, migration, and invasion of human hepatocellular carcinoma cells by activating epithelial-mesenchymal transition. Onco Targets Ther. 9:2035–2047. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Chen L, Guan H, Gu C, Cao Y, Shao J and Wang F: miR-383 inhibits hepatocellular carcinoma cell proliferation via targeting APRIL. Tumour Biol. 37:2497–2507. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Zhang Q, Zhao S, Pang X and Chi B: MicroRNA-381 suppresses cell growth and invasion by targeting the liver receptor homolog-1 in hepatocellular carcinoma. Oncol Rep. 35:1831–1840. 2016.PubMed/NCBI

9 

Massoumi R: CYLD: A deubiquitination enzyme with multiple roles in cancer. Future Oncol. 7:285–297. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Massoumi R, Chmielarska K, Hennecke K, Pfeifer A and Fässler R: Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell. 125:665–677. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Ni F, Gui Z, Guo Q, Hu Z, Wang X, Chen D and Wang S: Downregulation of miR-362-5p inhibits proliferation, migration and invasion of human breast cancer MCF7 cells. Oncol Lett. 11:1155–1160. 2016.PubMed/NCBI

12 

Pannem RR, Dorn C, Ahlqvist K, Bosserhoff AK, Hellerbrand C and Massoumi R: CYLD controls c-MYC expression through the JNK-dependent signaling pathway in hepatocellular carcinoma. Carcinogenesis. 35:461–468. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Tauriello DV, Haegebarth A, Kuper I, Edelmann MJ, Henraat M, Canninga-van Dijk MR, Kessler BM, Clevers H and Maurice MM: Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell. 37:607–619. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Yang G, Zhang X and Shi J: MiR-98 inhibits cell proliferation and invasion of non-small cell carcinoma lung cancer by targeting PAK1. Int J Clin Exp Med. 8:20135–20145. 2015.PubMed/NCBI

15 

Lv H, Zhang Z, Wang Y, Li C, Gong W and Wang X: MicroRNA-92a promotes colorectal cancer cell growth and migration by inhibiting KLF4. Oncol Res. 23:283–290. 2016. View Article : Google Scholar

16 

Shen F, Cai WS, Feng Z, Li JL, Chen JW, Cao J and Xu B: MiR-492 contributes to cell proliferation and cell cycle of human breast cancer cells by suppressing SOX7 expression. Tumour Biol. 36:1913–1921. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Xie BH, He X, Hua RX, Zhang B, Tan GS, Xiong SQ, Liu LS, Chen W, Yang JY, Wang XN, et al: Mir-765 promotes cell proliferation by downregulating INPP4B expression in human hepatocellular carcinoma. Cancer Biomark. 16:405–413. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Zhou X, Zhu HQ, Ma CQ, Li HG, Liu FF, Chang H and Lu J: MiR-1180 promoted the proliferation of hepatocellular carcinoma cells by repressing TNIP2 expression. Biomed Pharmacother. 79:315–320. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Chen JS, Li HS, Huang JQ, Dong SH, Huang ZJ, Yi W, Zhan GF, Feng JT, Sun JC and Huang XH: MicroRNA-379-5p inhibits tumor invasion and metastasis by targeting FAK/AKT signaling in hepatocellular carcinoma. Cancer Lett. 375:73–83. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Zhou X, Zhang L, Zheng B, Yan Y, Zhang Y, Xie H, Zhou L, Zheng S and Wang W: MicroRNA-761 is upregulated in hepatocellular carcinoma and regulates tumorigenesis by targeting Mitofusin-2. Cancer Sci. 107:424–432. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Urbanik T, Köhler BC, Boger RJ, Wörns MA, Heeger S, Otto G, Hövelmeyer N, Galle PR, Schuchmann M, Waisman A, et al: Down-regulation of CYLD as a trigger for NF-κB activation and a mechanism of apoptotic resistance in hepatocellular carcinoma cells. Int J Oncol. 38:121–131. 2011.PubMed/NCBI

22 

Guo J, Shinriki S, Su Y, Nakamura T, Hayashi M, Tsuda Y, Murakami Y, Tasaki M, Hide T, Takezaki T, et al: Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: Possible link to acquired resistance to anti-VEGF therapy. Oncotarget. 5:6353–6364. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Ke H, Augustine CK, Gandham VD, Jin JY, Tyler DS, Akiyama SK, Hall RP and Zhang JY: CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways. J Invest Dermatol. 133:221–229. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Hellerbrand C, Bumes E, Bataille F, Dietmaier W, Massoumi R and Bosserhoff AK: Reduced expression of CYLD in human colon and hepatocellular carcinomas. Carcinogenesis. 28:21–27. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Liang HL, Hu AP, Li SL, Xie JP, Ma QZ and Liu JY: MiR-454 prompts cell proliferation of human colorectal cancer cells by repressing CYLD expression. Asian Pac J Cancer Prev. 16:2397–2402. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Huang DH, Wang GY, Zhang JW, Li Y, Zeng XC and Jiang N: MiR-501-5p regulates CYLD expression and promotes cell proliferation in human hepatocellular carcinoma. Jpn J Clin Oncol. 45:738–744. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Su Z, Zeng Y, Zhang H, Yang S and Liu G: miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma. Oncol Rep 37: 1445-1450, 2017.
APA
Liu, J., Su, Z., Zeng, Y., Zhang, H., Yang, S., & Liu, G. (2017). miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma. Oncology Reports, 37, 1445-1450. https://doi.org/10.3892/or.2017.5431
MLA
Liu, J., Su, Z., Zeng, Y., Zhang, H., Yang, S., Liu, G."miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma". Oncology Reports 37.3 (2017): 1445-1450.
Chicago
Liu, J., Su, Z., Zeng, Y., Zhang, H., Yang, S., Liu, G."miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma". Oncology Reports 37, no. 3 (2017): 1445-1450. https://doi.org/10.3892/or.2017.5431
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Su Z, Zeng Y, Zhang H, Yang S and Liu G: miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma. Oncol Rep 37: 1445-1450, 2017.
APA
Liu, J., Su, Z., Zeng, Y., Zhang, H., Yang, S., & Liu, G. (2017). miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma. Oncology Reports, 37, 1445-1450. https://doi.org/10.3892/or.2017.5431
MLA
Liu, J., Su, Z., Zeng, Y., Zhang, H., Yang, S., Liu, G."miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma". Oncology Reports 37.3 (2017): 1445-1450.
Chicago
Liu, J., Su, Z., Zeng, Y., Zhang, H., Yang, S., Liu, G."miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma". Oncology Reports 37, no. 3 (2017): 1445-1450. https://doi.org/10.3892/or.2017.5431
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