miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma

Liu,Jianping; Su,Zheng; Zeng,Yunjie; Zhang,Huayao; Yang,Shanglin; Liu,Gaojie

doi:10.3892/or.2017.5431

miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma

Authors:
- Jianping Liu
- Zheng Su
- Yunjie Zeng
- Huayao Zhang
- Shanglin Yang
- Gaojie Liu
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Affiliations: Department of Hepato-Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China, Comprehensive Department, Sun Yat-sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China, Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China, Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China
Published online on: February 7, 2017 https://doi.org/10.3892/or.2017.5431
Pages: 1445-1450

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Abstract

Evidence reveals that microRNAs (miRNAs) play essential roles in hepatocellular carcinoma (HCC) tumorigenesis. In the present study, we identified an essential role for miR-922 in the development of HCC. We found that miR-922 was significantly upregulated in HCC cells and clinical tissues. Gain and loss of function studies indicated that miR-922 significantly promoted HCC cell proliferation. We subsequently identified that cylindromatosis (CYLD) was a target gene of miR-922. Moreover, miR-922 decreased CYLD expression, subsequently upregulating the expression of c-Myc and cyclin D1, while downregulating p-Rb expression. Furthermore, knockdown of CYLD expression by siRNA partially counteracted the tumor suppressive effect of the inhibitor of miR‑922, miR‑922-in. Taken together, our findings indicate that miR-922 plays a key role in the promotion of HCC cell proliferation, and strongly suggest that exogenous miR-922 may have therapeutic value for treating HCC.

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