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Article

Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1

Retraction in: /10.3892/or.2018.6688
  • Authors:
    • Tong-Han Zhang
    • Li-Zhong Liang
    • Xiao-Ling Liu
    • Ji-Nan Wu
    • Kui Su
    • Jue-Yao Chen
    • Qiao-Yi Zheng
    • Hong-Zhang Huang
    • Gui-Qing Liao
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, The Affiliated Zhongshan Hospital, Sun Yat-sen University, Zhongshan, Guangdong 528403, P.R. China, Department of Oral and Maxillofacial Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, P.R. China, Department of Medical Intensive Care Unit, The Affiliated Zhongshan Hospital, Sun Yat-sen University, Zhongshan, Guangdong 528403, P.R. China, Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, P.R. China
  • Pages: 2087-2094
    |
    Published online on: February 14, 2017
       https://doi.org/10.3892/or.2017.5445
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Abstract

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA (lncRNA), was the earliest discovered to be correlated with cancer and contributes to the initiation and development of several types of tumors. Dysregulation of MALAT1 expression is frequently observed in many types of cancer such as gastric cancer, esophageal squamous cell carcinoma and glioma. To date, the role of MALAT1 and the underlying mechanisms in tongue cancer development remain unclear. In the present study, we studied the influence of MALAT1 on tongue cancer cell lines and clinical tongue cancer samples so as to detect its function and the underlying mechanism. In the present study, lncRNA-MALAT1 was specifically upregulated in tongue cancer cell lines and overexpression promoted tongue cancer cell growth by targeting miR-124. Knockdown of MALAT1 suppressed the growth and invasion of human tongue cancer cells and inhibited metastasis in vitro and in vivo. In addition, miR-124-dependent jagged1 (JAG1) regulation was required for MALAT1-induced tongue cancer cell growth. Our data revealed that MALAT1 inhibited tongue cancer cell growth and metastasis through miR-124-dependent JAG1 regulation. In conclusion, we revealed that MALAT1 may play an oncogenic role by increasing proliferation and metastasis of tongue cancer and is a potential therapeutic target in human tongue cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang T, Liang L, Liu X, Wu J, Su K, Chen J, Zheng Q, Huang H and Liao G: Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1 Retraction in /10.3892/or.2018.6688. Oncol Rep 37: 2087-2094, 2017.
APA
Zhang, T., Liang, L., Liu, X., Wu, J., Su, K., Chen, J. ... Liao, G. (2017). Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1 Retraction in /10.3892/or.2018.6688. Oncology Reports, 37, 2087-2094. https://doi.org/10.3892/or.2017.5445
MLA
Zhang, T., Liang, L., Liu, X., Wu, J., Su, K., Chen, J., Zheng, Q., Huang, H., Liao, G."Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1 Retraction in /10.3892/or.2018.6688". Oncology Reports 37.4 (2017): 2087-2094.
Chicago
Zhang, T., Liang, L., Liu, X., Wu, J., Su, K., Chen, J., Zheng, Q., Huang, H., Liao, G."Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1 Retraction in /10.3892/or.2018.6688". Oncology Reports 37, no. 4 (2017): 2087-2094. https://doi.org/10.3892/or.2017.5445
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang T, Liang L, Liu X, Wu J, Su K, Chen J, Zheng Q, Huang H and Liao G: Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1 Retraction in /10.3892/or.2018.6688. Oncol Rep 37: 2087-2094, 2017.
APA
Zhang, T., Liang, L., Liu, X., Wu, J., Su, K., Chen, J. ... Liao, G. (2017). Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1 Retraction in /10.3892/or.2018.6688. Oncology Reports, 37, 2087-2094. https://doi.org/10.3892/or.2017.5445
MLA
Zhang, T., Liang, L., Liu, X., Wu, J., Su, K., Chen, J., Zheng, Q., Huang, H., Liao, G."Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1 Retraction in /10.3892/or.2018.6688". Oncology Reports 37.4 (2017): 2087-2094.
Chicago
Zhang, T., Liang, L., Liu, X., Wu, J., Su, K., Chen, J., Zheng, Q., Huang, H., Liao, G."Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1 Retraction in /10.3892/or.2018.6688". Oncology Reports 37, no. 4 (2017): 2087-2094. https://doi.org/10.3892/or.2017.5445
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