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Article

USP39 promotes colorectal cancer growth and metastasis through the Wnt/β-catenin pathway

  • Authors:
    • Xianwen Yuan
    • Xitai Sun
    • Xiaolei Shi
    • Hao Wang
    • Guoyi Wu
    • Chunping Jiang
    • Decai Yu
    • Weiwei Zhang
    • Bin Xue
    • Yitao Ding
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China, Jiangsu Province Key Medical Center for Hepatobiliary Disease, Nanjing, Jiangsu 210008, P.R. China, Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, Jiangsu 210093, P.R. China
  • Pages: 2398-2404
    |
    Published online on: February 15, 2017
       https://doi.org/10.3892/or.2017.5454
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Abstract

In the present study, we first examined the expression of USP39 protein using tissue array containing 90 colorectal cancer (CRC) tissues and 9 clinical samples, and observed that it has significantly higher expression in cancer tissues as compared to the corresponding adjacent normal tissues. Also, we tested USP39 expression level in four CRC cancer cell lines and identified that it indeed had higher expression in all these CRC cell lines. In addition, its knockdown inhibited not only the cell growth of SW480 and HT29 cells, but also the cell migration and invasion. Further analysis of its molecular mechanism suggested that the expression of four crucial proteins of Wnt/β-catenin pathway, including β-catenin, TCF4, MMP2 and MMP9 was reduced as a result of USP39 knockdown. Taken together, all these findings demonstrated that USP39 protein plays an important role in the growth and metastasis of colorectal cancer mainly through Wnt/β-catenin pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Yuan X, Sun X, Shi X, Wang H, Wu G, Jiang C, Yu D, Zhang W, Xue B, Ding Y, Ding Y, et al: USP39 promotes colorectal cancer growth and metastasis through the Wnt/β-catenin pathway. Oncol Rep 37: 2398-2404, 2017.
APA
Yuan, X., Sun, X., Shi, X., Wang, H., Wu, G., Jiang, C. ... Ding, Y. (2017). USP39 promotes colorectal cancer growth and metastasis through the Wnt/β-catenin pathway. Oncology Reports, 37, 2398-2404. https://doi.org/10.3892/or.2017.5454
MLA
Yuan, X., Sun, X., Shi, X., Wang, H., Wu, G., Jiang, C., Yu, D., Zhang, W., Xue, B., Ding, Y."USP39 promotes colorectal cancer growth and metastasis through the Wnt/β-catenin pathway". Oncology Reports 37.4 (2017): 2398-2404.
Chicago
Yuan, X., Sun, X., Shi, X., Wang, H., Wu, G., Jiang, C., Yu, D., Zhang, W., Xue, B., Ding, Y."USP39 promotes colorectal cancer growth and metastasis through the Wnt/β-catenin pathway". Oncology Reports 37, no. 4 (2017): 2398-2404. https://doi.org/10.3892/or.2017.5454
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan X, Sun X, Shi X, Wang H, Wu G, Jiang C, Yu D, Zhang W, Xue B, Ding Y, Ding Y, et al: USP39 promotes colorectal cancer growth and metastasis through the Wnt/β-catenin pathway. Oncol Rep 37: 2398-2404, 2017.
APA
Yuan, X., Sun, X., Shi, X., Wang, H., Wu, G., Jiang, C. ... Ding, Y. (2017). USP39 promotes colorectal cancer growth and metastasis through the Wnt/β-catenin pathway. Oncology Reports, 37, 2398-2404. https://doi.org/10.3892/or.2017.5454
MLA
Yuan, X., Sun, X., Shi, X., Wang, H., Wu, G., Jiang, C., Yu, D., Zhang, W., Xue, B., Ding, Y."USP39 promotes colorectal cancer growth and metastasis through the Wnt/β-catenin pathway". Oncology Reports 37.4 (2017): 2398-2404.
Chicago
Yuan, X., Sun, X., Shi, X., Wang, H., Wu, G., Jiang, C., Yu, D., Zhang, W., Xue, B., Ding, Y."USP39 promotes colorectal cancer growth and metastasis through the Wnt/β-catenin pathway". Oncology Reports 37, no. 4 (2017): 2398-2404. https://doi.org/10.3892/or.2017.5454
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