|
1
|
Simon JA and Kingston RE: Mechanisms of
polycomb gene silencing: Knowns and unknowns. Nat Rev Mol Cell
Biol. 10:697–708. 2009.PubMed/NCBI
|
|
2
|
Wang W, Qin JJ, Voruganti S, Nag S, Zhou J
and Zhang R: Polycomb group (PcG) proteins and human cancers:
Multifaceted functions and therapeutic implications. Med Res Rev.
35:1220–1267. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Park IK, Qian D, Kiel M, Becker MW,
Pihalja M, Weissman IL, Morrison SJ and Clarke MF: Bmi-1 is
required for maintenance of adult self-renewing haematopoietic stem
cells. Nature. 423:302–305. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Bruggeman SW, Valk-Lingbeek ME, van der
Stoop PP, Jacobs JJ, Kieboom K, Tanger E, Hulsman D, Leung C,
Arsenijevic Y, Marino S, et al: Ink4a and Arf differentially affect
cell proliferation and neural stem cell self-renewal in
Bmi1-deficient mice. Genes Dev. 19:1438–1443. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Yang MH, Hsu DS, Wang HW, Wang HJ, Lan HY,
Yang WH, Huang CH, Kao SY, Tzeng CH, Tai SK, et al: Bmi1 is
essential in Twist1-induced epithelial-mesenchymal transition. Nat
Cell Biol. 12:982–992. 2010. View
Article : Google Scholar : PubMed/NCBI
|
|
6
|
Jacobs JJ, Kieboom K, Marino S, DePinho RA
and van Lohuizen M: The oncogene and Polycomb-group gene bmi-1
regulates cell proliferation and senescence through the ink4a
locus. Nature. 397:164–168. 1999. View
Article : Google Scholar : PubMed/NCBI
|
|
7
|
Zhang FB, Sui LH and Xin T: Correlation of
Bmi-1 expression and telomerase activity in human ovarian cancer.
Br J Biomed Sci. 65:172–177. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Vonlanthen S, Heighway J, Altermatt HJ,
Gugger M, Kappeler A, Borner MM, van Lohuizen M and Betticher DC:
The bmi-1 oncoprotein is differentially expressed in non-small cell
lung cancer and correlates with INK4A-ARF locus expression. Br J
Cancer. 84:1372–1376. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Kim JH, Yoon SY, Kim CN, Joo JH, Moon SK,
Choe IS, Choe YK and Kim JW: The Bmi-1 oncoprotein is overexpressed
in human colorectal cancer and correlates with the reduced
p16INK4a/p14ARF proteins. Cancer Lett.
203:217–224. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Kim JH, Yoon SY, Jeong SH, Kim SY, Moon
SK, Joo JH, Lee Y, Choe IS and Kim JW: Overexpression of Bmi-1
oncoprotein correlates with axillary lymph node metastases in
invasive ductal breast cancer. Breast. 13:383–388. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Silva J, García V, García JM, Peña C,
Domínguez G, Díaz R, Lorenzo Y, Hurtado A, Sánchez A and Bonilla F:
Circulating Bmi-1 mRNA as a possible prognostic factor for advanced
breast cancer patients. Breast Cancer Res. 9:R552007. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Zhang R, Xu LB, Yue XJ, Yu XH, Wang J and
Liu C: Bmi1 gene silencing inhibits the proliferation and
invasiveness of human hepatocellular carcinoma cells and increases
their sensitivity to 5-fluorouracil. Oncol Rep. 29:967–974.
2013.PubMed/NCBI
|
|
13
|
Xu XH, Liu XY, Su J, Li DJ, Huang Q, Lu
MQ, Yi F, Ren JH and Chen WH: ShRNA targeting Bmi-1 sensitizes
CD44+ nasopharyngeal cancer stem-like cells to
radiotherapy. Oncol Rep. 32:764–770. 2014.PubMed/NCBI
|
|
14
|
Wang G, Liu L, Sharma S, Liu H, Yang W,
Sun X and Dong Q: Bmi-1 confers adaptive radioresistance to
KYSE-150R esophageal carcinoma cells. Biochem Biophys Res Commun.
425:309–314. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Dong Q, Oh JE, Chen W, Kim R, Kim RH, Shin
KH, McBride WH, Park NH and Kang MK: Radioprotective effects of
Bmi-1 involve epigenetic silencing of oxidase genes and enhanced
DNA repair in normal human keratinocytes. J Invest Dermatol.
131:1216–1225. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Facchino S, Abdouh M, Chatoo W and Bernier
G: BMI1 confers radioresistance to normal and cancerous neural stem
cells through recruitment of the DNA damage response machinery. J
Neurosci. 30:10096–10111. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Long CL, Berry WL, Zhao Y, Sun XH and
Humphrey MB: E proteins regulate osteoclast maturation and
survival. J Bone Miner Res. 27:2476–2489. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Muralidharan R, Panneerselvam J, Chen A,
Zhao YD, Munshi A and Ramesh R: HuR-targeted nanotherapy in
combination with AMD3100 suppresses CXCR4 expression, cell growth,
migration and invasion in lung cancer. Cancer Gene Ther.
22:581–590. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Munshi A, Tanaka T, Hobbs ML, Tucker SL,
Richon VM and Meyn RE: Vorinostat, a histone deacetylase inhibitor,
enhances the response of human tumor cells to ionizing radiation
through prolongation of gamma-H2AX foci. Mol Cancer Ther.
5:1967–1974. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Munshi A, Kurland JF, Nishikawa T, Tanaka
T, Hobbs ML, Tucker SL, Ismail S, Stevens C and Meyn RE: Histone
deacetylase inhibitors radiosensitize human melanoma cells by
suppressing DNA repair activity. Clin Cancer Res. 11:4912–4922.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Kroemer G, Mariño G and Levine B:
Autophagy and the integrated stress response. Mol Cell. 40:280–293.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Proctor E, Waghray M, Lee CJ, Heidt DG,
Yalamanchili M, Li C, Bednar F and Simeone DM: Bmi1 enhances
tumorigenicity and cancer stem cell function in pancreatic
adenocarcinoma. PLoS One. 8:e558202013. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Santivasi WL and Xia F: Ionizing
radiation-induced DNA damage, response, and repair. Antioxid Redox
Signal. 21:251–259. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Khanna KK and Jackson SP: DNA
double-strand breaks: Signaling, repair and the cancer connection.
Nat Genet. 27:247–254. 2001. View
Article : Google Scholar : PubMed/NCBI
|
|
25
|
Olive PL: The role of DNA single- and
double-strand breaks in cell killing by ionizing radiation. Radiat
Res. 150:(Suppl). S42–S51. 1998. View
Article : Google Scholar : PubMed/NCBI
|
|
26
|
Liu J, Cao L, Chen J, Song S, Lee IH,
Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, et al: Bmi1
regulates mitochondrial function and the DNA damage response
pathway. Nature. 459:387–392. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Apel A, Herr I, Schwarz H, Rodemann HP and
Mayer A: Blocked autophagy sensitizes resistant carcinoma cells to
radiation therapy. Cancer Res. 68:1485–1494. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Fujiwara K, Iwado E, Mills GB, Sawaya R,
Kondo S and Kondo Y: Akt inhibitor shows anticancer and
radiosensitizing effects in malignant glioma cells by inducing
autophagy. Int J Oncol. 31:753–760. 2007.PubMed/NCBI
|
|
29
|
Sui X, Kong N, Ye L, Han W, Zhou J, Zhang
Q, He C and Pan H: p38 and JNK MAPK pathways control the balance of
apoptosis and autophagy in response to chemotherapeutic agents.
Cancer Lett. 344:174–179. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Ge J, Liu Y, Li Q, Guo X, Gu L, Ma ZG and
Zhu YP: Resveratrol induces apoptosis and autophagy in T-cell acute
lymphoblastic leukemia cells by inhibiting Akt/mTOR and activating
p38-MAPK. Biomed Environ Sci. 26:902–911. 2013.PubMed/NCBI
|
|
31
|
Dong Q, Sharma S, Liu H, Chen L, Gu B, Sun
X and Wang G: HDAC inhibitors reverse acquired radio resistance of
KYSE-150R esophageal carcinoma cells by modulating Bmi-1
expression. Toxicol Lett. 224:121–129. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Gong XM, Zhang Q, Torossian A, Cao JP and
Fu S: Selective radiosensitization of human cervical cancer cells
and normal cells by artemisinin through the abrogation of
radiation-induced G2 block. Int J Gynecol Cancer. 22:718–724. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Wu J, Hu D, Yang G, Zhou J, Yang C, Gao Y
and Zhu Z: Down-regulation of BMI-1 cooperates with artemisinin on
growth inhibition of nasopharyngeal carcinoma cells. J Cell
Biochem. 112:1938–1948. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Kreso A, van Galen P, Pedley NM,
Lima-Fernandes E, Frelin C, Davis T, Cao L, Baiazitov R, Du W,
Sydorenko N, et al: Self-renewal as a therapeutic target in human
colorectal cancer. Nat Med. 20:29–36. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Bolomsky A, Schlangen K, Schreiner W,
Zojer N and Ludwig H: Targeting of BMI-1 with PTC-209 shows potent
anti-myeloma activity and impairs the tumour microenvironment. J
Hematol Oncol. 9:172016. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Mayr C, Wagner A, Loeffelberger M,
Bruckner D, Jakab M, Berr F, Di Fazio P, Ocker M, Neureiter D,
Pichler M, et al: The BMI1 inhibitor PTC-209 is a potential
compound to halt cellular growth in biliary tract cancer cells.
Oncotarget. 7:745–758. 2016.PubMed/NCBI
|
