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miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells

  • Authors:
    • Ya Xu
    • Yanfen Zhang
    • Lujing Wang
    • Ruiqi Zhao
    • Yu Qiao
    • Dong Han
    • Qian Sun
    • Nazhen Dong
    • Yicong Liu
    • Dantong Wu
    • Xuemei Zhang
    • Ning Huang
    • Ning Ma
    • Weiming Zhao
    • Yanhong Liu
    • Xu Gao
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, Heilongjiang, P.R. China, Department of Laboratory Diagnosis, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2711-2719
    |
    Published online on: March 15, 2017
       https://doi.org/10.3892/or.2017.5506
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Abstract

Microvesicle biogenesis is a highly regulated process. Aberrant release of microvesicles from cancer cells have been associated with their invasiveness and prognosis. However, the mechanism of aberrant release remains poorly understood. Herein, we found that hepatocellular carcinoma cells shed more microvesicles than normal hepatocytes and miR-200a were shown to inhibit the release of microvesicles in hepatocellular carcinoma cells. Then, we confirmed that miR-200a might target Gelsolin and change cytoskeleton to regulate microvesicles secretion. Further miR-200a may inhibit the proliferation of adjacent cells by inhibiting the release of microvesicles. Collectively, our findings indicate that miR-200a regulated the microvesicle biogenesis involved in the hepatocellular carcinoma progression.
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1 

Antonyak MA, Wilson KF and Cerione RA: R(h)oads to microvesicles. Small GTPases. 3:219–224. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Wang W, Li H, Zhou Y and Jie S: Peripheral blood microvesicles are potential biomarkers for hepatocellular carcinoma. Cancer Biomark. 13:351–357. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Antonyak MA and Cerione RA: Microvesicles as mediators of intercellular communication in cancer. Methods Mol Biol. 1165:147–173. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Li B, Antonyak MA, Zhang J and Cerione RA: RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells. Oncogene. 31:4740–4749. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Wagner-Britz L, Wang J, Kaestner L and Bernhardt I: Protein kinase Cα and P-type Ca channel CaV2.1 in red blood cell calcium signalling. Cell Physiol Biochem. 31:883–891. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Nguyen DB, Ly TB, Wesseling MC, Hittinger M, Torge A, Devitt A, Perrie Y and Bernhardt I: Characterization of microvesicles released from human red blood cells. Cell Physiol Biochem. 38:1085–1099. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Sun HQ, Yamamoto M, Mejillano M and Yin HL: Gelsolin, a multifunctional actin regulatory protein. J Biol Chem. 274:33179–33182. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Yin HL and Stossel TP: Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein. Nature. 281:583–586. 1979. View Article : Google Scholar : PubMed/NCBI

9 

Li F, Ma N, Zhao R, Wu G, Zhang Y, Qiao Y, Han D, Xu Y, Xiang Y, Yan B, et al: Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice. J Cell Mol Med. 18:966–974. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Chen L, Charrier A, Zhou Y, Chen R, Yu B, Agarwal K, Tsukamoto H, Lee LJ, Paulaitis ME and Brigstock DR: Epigenetic regulation of connective tissue growth factor by microRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology. 59:1118–1129. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Qu Z, Jiang C, Wu J and Ding Y: Exosomes as potent regulators of HCC malignancy and potential bio-tools in clinical application. Int J Clin Exp Med. 8:17088–17095. 2015.PubMed/NCBI

12 

Kogure T, Lin WL, Yan IK, Braconi C and Patel T: Intercellular nanovesicle-mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growth. Hepatology. 54:1237–1248. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Wang H, Hou L, Li A, Duan Y, Gao H and Song X: Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma. BioMed Res Int. 2014:8648942014.PubMed/NCBI

14 

Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST and Patel T: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology. 133:647–658. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Lin CJ, Gong HY, Tseng HC, Wang WL and Wu JL: miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. 375:315–320. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Korpal M, Lee ES, Hu G and Kang Y: The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 283:14910–14914. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L, et al: MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene. 27:5651–5661. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z, Sun F, Lu J, Yin Y, Cai X, et al: Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell. 39:133–144. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Guescini M, Genedani S, Stocchi V and Agnati LF: Astrocytes and glioblastoma cells release exosomes carrying mtDNA. J Neural Transm Vienna. 117:1–4. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Nielsen TB, Nielsen MH and Handberg A: In vitro incubation of platelets with oxLDL does not induce microvesicle release when measured by sensitive flow cytometry. Front Cardiovasc Med. 2:372015. View Article : Google Scholar : PubMed/NCBI

21 

Théry C, Boussac M, Véron P, Ricciardi-Castagnoli P, Raposo G, Garin J and Amigorena S: Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles. J Immunol. 166:7309–7318. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T and Shimotohno K: Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene. 25:2537–2545. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Ma N, Li F, Li D, Hui Y, Wang X, Qiao Y, Zhang Y, Xiang Y, Zhou J, Zhou L, et al: Igf2-derived intronic miR-483 promotes mouse hepatocellular carcinoma cell proliferation. Mol Cell Biochem. 361:337–343. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Wu X, Wu G, Wu Z, Yao X and Li G: MiR-200a suppresses the proliferation and metastasis in pancreatic ductal adenocarcinoma through downregulation of DEK Gene. Transl Oncol. 9:25–31. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Wang X, Jiang F, Song H, Li X, Xian J and Gu X: MicroRNA-200a-3p suppresses tumor proliferation and induces apoptosis by targeting SPAG9 in renal cell carcinoma. Biochem Biophys Res Commun. 470:620–626. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Tsouko E, Wang J, Frigo DE, Aydoğdu E and Williams C: miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene. Carcinogenesis. 36:1051–1060. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Kholia S, Jorfi S, Thompson PR, Causey CP, Nicholas AP, Inal JM and Lange S: A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy. J Extracell Vesicles. 4:261922015. View Article : Google Scholar : PubMed/NCBI

28 

Piccin A, Murphy WG and Smith OP: Circulating microparticles: Pathophysiology and clinical implications. Blood Rev. 21:157–171. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Yin HL, Hartwig JH, Maruyama K and Stossel TP: Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization. J Biol Chem. 256:9693–9697. 1981.PubMed/NCBI

30 

Du T, Ju G, Wu S, Cheng Z, Cheng J, Zou X, Zhang G, Miao S, Liu G and Zhu Y: Microvesicles derived from human Wharton's jelly mesenchymal stem cells promote human renal cancer cell growth and aggressiveness through induction of hepatocyte growth factor. PLoS One. 9:e968362014. View Article : Google Scholar : PubMed/NCBI

31 

Al-Nedawi K, Meehan B, Micallef J, Lhotak V, May L, Guha A and Rak J: Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol. 10:619–624. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M and Wrana JL: Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell. 151:1542–1556. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Wei JX, Lv LH, Wan YL, Cao Y, Li GL, Lin HM, Zhou R, Shang CZ, Cao J, He H, et al: Vps4A functions as a tumor suppressor by regulating the secretion and uptake of exosomal microRNAs in human hepatoma cells. Hepatology. 61:1284–1294. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Zhang W, Zhao P, Xu XL, Cai L, Song ZS, Cao DY, Tao KS, Zhou WP, Chen ZN and Dou KF: Annexin A2 promotes the migration and invasion of human hepatocellular carcinoma cells in vitro by regulating the shedding of CD147-harboring microvesicles from tumor cells. PLoS One. 8:e672682013. View Article : Google Scholar : PubMed/NCBI

35 

Li GH, Arora PD, Chen Y, McCulloch CA and Liu P: Multifunctional roles of gelsolin in health and diseases. Med Res Rev. 32:999–1025. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Eun DW, Ahn SH, You JS, Park JW, Lee EK, Lee HN, Kang GM, Lee JC, Choi WS, Seo DW, et al: PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells. Biochem Biophys Res Commun. 354:769–775. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Zhang Y, Wang L, Zhao R, Qiao Y, Han D, Sun Q, Dong N, Liu Y, Wu D, Wu D, et al: miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells. Oncol Rep 37: 2711-2719, 2017.
APA
Xu, Y., Zhang, Y., Wang, L., Zhao, R., Qiao, Y., Han, D. ... Gao, X. (2017). miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells. Oncology Reports, 37, 2711-2719. https://doi.org/10.3892/or.2017.5506
MLA
Xu, Y., Zhang, Y., Wang, L., Zhao, R., Qiao, Y., Han, D., Sun, Q., Dong, N., Liu, Y., Wu, D., Zhang, X., Huang, N., Ma, N., Zhao, W., Liu, Y., Gao, X."miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells". Oncology Reports 37.5 (2017): 2711-2719.
Chicago
Xu, Y., Zhang, Y., Wang, L., Zhao, R., Qiao, Y., Han, D., Sun, Q., Dong, N., Liu, Y., Wu, D., Zhang, X., Huang, N., Ma, N., Zhao, W., Liu, Y., Gao, X."miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells". Oncology Reports 37, no. 5 (2017): 2711-2719. https://doi.org/10.3892/or.2017.5506
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Zhang Y, Wang L, Zhao R, Qiao Y, Han D, Sun Q, Dong N, Liu Y, Wu D, Wu D, et al: miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells. Oncol Rep 37: 2711-2719, 2017.
APA
Xu, Y., Zhang, Y., Wang, L., Zhao, R., Qiao, Y., Han, D. ... Gao, X. (2017). miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells. Oncology Reports, 37, 2711-2719. https://doi.org/10.3892/or.2017.5506
MLA
Xu, Y., Zhang, Y., Wang, L., Zhao, R., Qiao, Y., Han, D., Sun, Q., Dong, N., Liu, Y., Wu, D., Zhang, X., Huang, N., Ma, N., Zhao, W., Liu, Y., Gao, X."miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells". Oncology Reports 37.5 (2017): 2711-2719.
Chicago
Xu, Y., Zhang, Y., Wang, L., Zhao, R., Qiao, Y., Han, D., Sun, Q., Dong, N., Liu, Y., Wu, D., Zhang, X., Huang, N., Ma, N., Zhao, W., Liu, Y., Gao, X."miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells". Oncology Reports 37, no. 5 (2017): 2711-2719. https://doi.org/10.3892/or.2017.5506
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