Open Access

miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells

  • Authors:
    • Ya Xu
    • Yanfen Zhang
    • Lujing Wang
    • Ruiqi Zhao
    • Yu Qiao
    • Dong Han
    • Qian Sun
    • Nazhen Dong
    • Yicong Liu
    • Dantong Wu
    • Xuemei Zhang
    • Ning Huang
    • Ning Ma
    • Weiming Zhao
    • Yanhong Liu
    • Xu Gao
  • View Affiliations

  • Published online on: March 15, 2017     https://doi.org/10.3892/or.2017.5506
  • Pages: 2711-2719
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Microvesicle biogenesis is a highly regulated process. Aberrant release of microvesicles from cancer cells have been associated with their invasiveness and prognosis. However, the mechanism of aberrant release remains poorly understood. Herein, we found that hepatocellular carcinoma cells shed more microvesicles than normal hepatocytes and miR-200a were shown to inhibit the release of microvesicles in hepatocellular carcinoma cells. Then, we confirmed that miR-200a might target Gelsolin and change cytoskeleton to regulate microvesicles secretion. Further miR-200a may inhibit the proliferation of adjacent cells by inhibiting the release of microvesicles. Collectively, our findings indicate that miR-200a regulated the microvesicle biogenesis involved in the hepatocellular carcinoma progression.
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May-2017
Volume 37 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Xu Y, Zhang Y, Wang L, Zhao R, Qiao Y, Han D, Sun Q, Dong N, Liu Y, Wu D, Wu D, et al: miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells. Oncol Rep 37: 2711-2719, 2017.
APA
Xu, Y., Zhang, Y., Wang, L., Zhao, R., Qiao, Y., Han, D. ... Gao, X. (2017). miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells. Oncology Reports, 37, 2711-2719. https://doi.org/10.3892/or.2017.5506
MLA
Xu, Y., Zhang, Y., Wang, L., Zhao, R., Qiao, Y., Han, D., Sun, Q., Dong, N., Liu, Y., Wu, D., Zhang, X., Huang, N., Ma, N., Zhao, W., Liu, Y., Gao, X."miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells". Oncology Reports 37.5 (2017): 2711-2719.
Chicago
Xu, Y., Zhang, Y., Wang, L., Zhao, R., Qiao, Y., Han, D., Sun, Q., Dong, N., Liu, Y., Wu, D., Zhang, X., Huang, N., Ma, N., Zhao, W., Liu, Y., Gao, X."miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells". Oncology Reports 37, no. 5 (2017): 2711-2719. https://doi.org/10.3892/or.2017.5506